Liquid Active Zones for Controlling the Phases of Synaptic Transmission.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular cell"
DOI: 10.1016/j.molcel.2019.02.020
Abstract: Wu et al. (2019) establish that the active zone proteins RIM and RIM-BP undergo liquid-liquid phase separation to tether Ca2+ channels. This important finding sets a new framework to study assembly and function of the presynaptic… read more here.
Keywords: active zones; liquid active; zones controlling; synaptic transmission ... See more keywords
Vesicle release site organization at synaptic active zones
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience Research"
DOI: 10.1016/j.neures.2017.12.006
Abstract: Information transfer between nerve cells (neurons) forms the basis of behavior, emotion, and survival. Signal transduction from one neuron to another occurs at synapses, and relies on both electrical and chemical signal propagation. At chemical… read more here.
Keywords: release site; vesicle release; active zones; organization synaptic ... See more keywords
Effects of exercise training on neuromuscular junctions and their active zones in young and aged muscles
Sign Up to like & getrecommendations! Published in 2020 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2020.07.001
Abstract: The neuromuscular junction (NMJ) connects the motor neuron with myofibers allowing muscle contraction. Both aging and increased activity result in NMJ remodeling. Here, the effects of exercise were examined in young and aged soleus muscles.… read more here.
Keywords: active zones; aged muscles; training neuromuscular; young aged ... See more keywords
Endogenous tagging of Unc-13 reveals nanoscale reorganization at active zones during presynaptic homeostatic potentiation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.1074304
Abstract: Neurotransmitter release at presynaptic active zones (AZs) requires concerted protein interactions within a dense 3D nano-hemisphere. Among the complex protein mesh-work the (M)unc-13 family member Unc-13 of Drosophila melanogaster is essential for docking of synaptic… read more here.
Keywords: homeostatic potentiation; presynaptic homeostatic; active zones; unc 13gfstf ... See more keywords
Probabilities of evoked and spontaneous synaptic transmission at individual active zones: Lessons from Drosophila
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2022.1110538
Abstract: Nerve terminals release neuronal transmitters at morphological specializations known as active zones (AZs). Synaptic vesicle fusion at individual AZs is probabilistic, and this property is fundamental for the neuronal information transfer. Until recently, a lack… read more here.
Keywords: evoked spontaneous; spontaneous synaptic; individual azs; transmission ... See more keywords
Selective Enrichment of Munc13-2 in Presynaptic Active Zones of Hippocampal Pyramidal Cells That Innervate mGluR1α Expressing Interneurons
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2021.773209
Abstract: Selective distribution of proteins in presynaptic active zones (AZs) is a prerequisite for generating postsynaptic target cell type-specific differences in presynaptic vesicle release probability (Pv) and short-term plasticity, a characteristic feature of cortical pyramidal cells… read more here.
Keywords: mglur1 expressing; munc13; expressing interneurons; presynaptic active ... See more keywords
Visualizing Presynaptic Active Zones and Synaptic Vesicles
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Synaptic Neuroscience"
DOI: 10.3389/fnsyn.2022.901341
Abstract: The presynaptic active zone (AZ) of chemical synapses is a highly dynamic compartment where synaptic vesicle fusion and neurotransmitter release take place. During evolution the AZ was optimized for speed, accuracy, and reliability of chemical… read more here.
Keywords: synaptic vesicles; microscopy; presynaptic active; zones synaptic ... See more keywords
Munc13 supports fusogenicity of non-docked vesicles at synapses with disrupted active zones
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.79077
Abstract: Active zones consist of protein scaffolds that are tightly attached to the presynaptic plasma membrane. They dock and prime synaptic vesicles, couple them to voltage-gated Ca2+ channels, and direct neurotransmitter release toward postsynaptic receptor domains.… read more here.
Keywords: fusogenicity; active zone; rim elks; munc13 supports ... See more keywords