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   Articles with "activin" as a keyword



Combinatorial Inhibition of Myostatin and Activin A Improves Femoral Bone Properties in the G610C Mouse Model of Osteogenesis Imperfecta

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recommendations! Published in 2022 at "Journal of Bone and Mineral Research"

DOI: 10.1002/jbmr.4529

Abstract: Osteogenesis imperfecta (OI) is a collagen‐related bone disorder characterized by fragile osteopenic bone and muscle weakness. We have previously shown that the soluble activin receptor type IIB decoy (sActRIIB) molecule increases muscle mass and improves… read more here.

Keywords: g610c; bone; activin; g610c mice ... See more keywords

Activin-A in the regulation of immunity in health and disease.

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recommendations! Published in 2019 at "Journal of autoimmunity"

DOI: 10.1016/j.jaut.2019.102314

Abstract: The TGF-β superfamily of cytokines plays pivotal roles in the regulation of immune responses protecting against or contributing to diseases, such as, allergy, autoimmunity and cancer. Activin-A, a member of the TGF-β superfamily, was initially… read more here.

Keywords: regulation immunity; activin; cell; activin regulation ... See more keywords
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miR-181a promotes porcine granulosa cell apoptosis by targeting TGFBR1 via the activin signaling pathway

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recommendations! Published in 2020 at "Molecular and Cellular Endocrinology"

DOI: 10.1016/j.mce.2019.110603

Abstract: Activin/Smad3 signaling plays a pivotal role in follicle development and atresia. However, the precise mechanisms underlying this process are not yet fully understood. Herein, we identified miR-181a as a central component of activin/Smad3-mediated follicle atresia.… read more here.

Keywords: activin; apoptosis; apoptosis targeting; porcine granulosa ... See more keywords

Activin B improves glucose metabolism via induction of Fgf21 and hepatic glucagon resistance

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recommendations! Published in 2025 at "Nature Communications"

DOI: 10.1038/s41467-025-58836-w

Abstract: Orchestrated hormonal interactions in response to feeding and fasting play a pivotal role in regulating glucose homeostasis. Here, we show that in obesity, the production of follistatin-like 3 (FSTL3), an endogenous inhibitor of Activin B,… read more here.

Keywords: hepatic glucagon; activin improves; glucagon resistance; activin ... See more keywords

Role of stromal activin A in human pancreatic cancer and metastasis in mice

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-87213-y

Abstract: Pancreatic ductal adenocarcinoma (PDAC) has extensive stromal involvement and remains one of the cancers with the highest mortality rates. Activin A has been implicated in colon cancer and its stroma but its role in the… read more here.

Keywords: activin; pdac; stroma; role ... See more keywords
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The association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan

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recommendations! Published in 2021 at "Scientific Reports"

DOI: 10.1038/s41598-021-99081-7

Abstract: Activin A, a cytokine belonging to the transforming growth factor-β family, has been shown to play pivotal roles in tissue remodeling after renal injury and is present in elevated levels in diabetic patients. However, the… read more here.

Keywords: activin; dwelling middle; aged older; community dwelling ... See more keywords

Activin A affects colorectal cancer progression and immunomodulation in a stage dependent manner

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-91853-9

Abstract: Advanced colorectal cancer (CRC) continues to present with poor survival and treatment options remain limited. We have shown that increased activin A (activin) expression in the tumor microenvironment (TME) is associated with poor outcome in… read more here.

Keywords: colorectal cancer; stage iii; crc; stage ... See more keywords

Activin A is increased in the nucleus accumbens following a cocaine binge

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recommendations! Published in 2017 at "Scientific Reports"

DOI: 10.1038/srep43658

Abstract: Drug addiction is a long-lasting disease characterized by compulsive drug intake mediated in part by neuronal and biological adaptations in key brain areas, such as the nucleus accumbens (NAc). While we previously demonstrated involvement of… read more here.

Keywords: cocaine binge; activin; following cocaine; nucleus accumbens ... See more keywords
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Effect of Hesperidin against Induced Colon Cancer in Rats: Impact of Smad4 and Activin A Signaling Pathway.

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recommendations! Published in 2021 at "Nutrition and cancer"

DOI: 10.1080/01635581.2021.1907424

Abstract: SCOPE To evaluate the chemopreventive efficacy of hesperidin (Hsd) in 1,2-dimethylhydrazine (DMH)-induced colorectal cancer (CRC) and demonstrate its role in mothers against decapentaplegic homolog 4(Smad4) and activin A signaling pathways. METHODS AND RESULTS A CRC… read more here.

Keywords: hsd; activin signaling; activin; smad4 activin ... See more keywords

Activin A promotes hyaluronan production and upregulates versican expression in human granulosa cells

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recommendations! Published in 2022 at "Biology of Reproduction"

DOI: 10.1093/biolre/ioac070

Abstract: Abstract Hyaluronan is a structural component of the expanded cumulus matrix, and hyaluronan synthase 2 is the major enzyme for the synthesis of hyaluronan in humans. Versican cross-links the hyaluronan-rich matrix to cumulus cells and… read more here.

Keywords: human granulosa; activin; production; hyaluronan ... See more keywords

#806 Serum activin A and bone metabolism in patients undergoing hemodialysis

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recommendations! Published in 2025 at "Nephrology Dialysis Transplantation"

DOI: 10.1093/ndt/gfaf116.1702

Abstract: Activin A, a widely expressed factor involved in cell differentiation, proliferation, and inflammation, is increased with declining kidney function. It promotes osteoclast differentiation in kidney failure, and might be involved in bone metabolism abnormalities in… read more here.

Keywords: serum activin; bone metabolism; activin; hemodialysis ... See more keywords