Combinatorial Inhibition of Myostatin and Activin A Improves Femoral Bone Properties in the G610C Mouse Model of Osteogenesis Imperfecta
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4529
Abstract: Osteogenesis imperfecta (OI) is a collagen‐related bone disorder characterized by fragile osteopenic bone and muscle weakness. We have previously shown that the soluble activin receptor type IIB decoy (sActRIIB) molecule increases muscle mass and improves… read more here.
Keywords: g610c; bone; activin; g610c mice ... See more keywords
Activin-A in the regulation of immunity in health and disease.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of autoimmunity"
DOI: 10.1016/j.jaut.2019.102314
Abstract: The TGF-β superfamily of cytokines plays pivotal roles in the regulation of immune responses protecting against or contributing to diseases, such as, allergy, autoimmunity and cancer. Activin-A, a member of the TGF-β superfamily, was initially… read more here.
Keywords: regulation immunity; activin; cell; activin regulation ... See more keywords
miR-181a promotes porcine granulosa cell apoptosis by targeting TGFBR1 via the activin signaling pathway
Sign Up to like & getrecommendations! Published in 2020 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2019.110603
Abstract: Activin/Smad3 signaling plays a pivotal role in follicle development and atresia. However, the precise mechanisms underlying this process are not yet fully understood. Herein, we identified miR-181a as a central component of activin/Smad3-mediated follicle atresia.… read more here.
Keywords: activin; apoptosis; apoptosis targeting; porcine granulosa ... See more keywords
Role of stromal activin A in human pancreatic cancer and metastasis in mice
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-87213-y
Abstract: Pancreatic ductal adenocarcinoma (PDAC) has extensive stromal involvement and remains one of the cancers with the highest mortality rates. Activin A has been implicated in colon cancer and its stroma but its role in the… read more here.
Keywords: activin; pdac; stroma; role ... See more keywords
The association between serum activin A levels and albuminuria among community-dwelling middle-aged and older adults in Taiwan
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-99081-7
Abstract: Activin A, a cytokine belonging to the transforming growth factor-β family, has been shown to play pivotal roles in tissue remodeling after renal injury and is present in elevated levels in diabetic patients. However, the… read more here.
Keywords: activin; dwelling middle; aged older; community dwelling ... See more keywords
Activin A is increased in the nucleus accumbens following a cocaine binge
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/srep43658
Abstract: Drug addiction is a long-lasting disease characterized by compulsive drug intake mediated in part by neuronal and biological adaptations in key brain areas, such as the nucleus accumbens (NAc). While we previously demonstrated involvement of… read more here.
Keywords: cocaine binge; activin; following cocaine; nucleus accumbens ... See more keywords
Effect of Hesperidin against Induced Colon Cancer in Rats: Impact of Smad4 and Activin A Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Nutrition and cancer"
DOI: 10.1080/01635581.2021.1907424
Abstract: SCOPE To evaluate the chemopreventive efficacy of hesperidin (Hsd) in 1,2-dimethylhydrazine (DMH)-induced colorectal cancer (CRC) and demonstrate its role in mothers against decapentaplegic homolog 4(Smad4) and activin A signaling pathways. METHODS AND RESULTS A CRC… read more here.
Keywords: hsd; activin signaling; activin; smad4 activin ... See more keywords
Activin A promotes hyaluronan production and upregulates versican expression in human granulosa cells
Sign Up to like & getrecommendations! Published in 2022 at "Biology of Reproduction"
DOI: 10.1093/biolre/ioac070
Abstract: Abstract Hyaluronan is a structural component of the expanded cumulus matrix, and hyaluronan synthase 2 is the major enzyme for the synthesis of hyaluronan in humans. Versican cross-links the hyaluronan-rich matrix to cumulus cells and… read more here.
Keywords: human granulosa; activin; production; hyaluronan ... See more keywords
Activin receptor ligand traps in chronic kidney disease
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Nephrology and Hypertension"
DOI: 10.1097/mnh.0000000000000433
Abstract: Purpose of review Sotatercept and luspatercept are recombinant soluble activin type-II receptor-IgG-Fc fusion proteins that are tested in clinical trials for the treatment of various types of anemias, including renal anemia. The mechanism of the… read more here.
Keywords: activin; chronic kidney; receptor; ligand traps ... See more keywords
Activin type II receptor signaling in cardiac aging and heart failure
Sign Up to like & getrecommendations! Published in 2019 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aau8680
Abstract: Activin type II receptor signaling regulates cardiac function in aging and heart failure by modulating proteasome-dependent SERCA2a degradation. Aging, activins, and heart failure Age is a risk factor for heart failure, but the underlying mechanisms… read more here.
Keywords: activin; actrii signaling; heart; heart failure ... See more keywords
ACTRIIA-Fc rebalances activin/GDF versus BMP signaling in pulmonary hypertension
Sign Up to like & getrecommendations! Published in 2020 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aaz5660
Abstract: ACTRIIA-Fc, an activin and GDF8/11 ligand trap, improves hemodynamics and exerts antiremodeling effects in experimental pulmonary hypertension. Remedying pulmonary vascular remodeling Alterations in bone morphogenetic protein, growth and differentiation factor (GDF), and transforming growth factor–β… read more here.
Keywords: protein; bmp signaling; activin; pulmonary hypertension ... See more keywords