The crucial role of activin A/ALK4 pathway in the pathogenesis of Ang-II-induced atrial fibrosis and vulnerability to atrial fibrillation
Sign Up to like & getrecommendations! Published in 2017 at "Basic Research in Cardiology"
DOI: 10.1007/s00395-017-0634-1
Abstract: AbstractsAtrial fibrosis, the hallmark of structural remodeling associated with atrial fibrillation (AF), is characterized by abnormal proliferation of atrial fibroblasts and excessive deposition of extracellular matrix. Transforming growth factor-β1 (TGF-β1)/activin receptor-like kinase 5 (ALK5)/Smad2/3/4 pathway… read more here.
Keywords: fibrosis; activin alk4; pathogenesis; atrial fibrosis ... See more keywords
Activin A and ALK4 Identified as Novel Regulators of Epithelial to Mesenchymal Transition (EMT) in Human Epicardial Cells
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.765007
Abstract: The epicardium, the mesothelial layer covering the heart, is a crucial cell source for cardiac development and repair. It provides cells and biochemical signals to the heart to facilitate vascularization and myocardial growth. An essential… read more here.
Keywords: mesenchymal transition; activin alk4; epicardial cells; novel regulators ... See more keywords