Detection of activin receptor type IIA and IIB-Fc fusion proteins by automated capillary immunoassay.
Sign Up to like & getrecommendations! Published in 2022 at "Drug testing and analysis"
DOI: 10.1002/dta.3378
Abstract: Activin receptor type IIA and type IIB fusion protein have been designed to sequester circulating molecules of the TGF-β superfamily and inactivate their actions. Members of this superfamily have been reported as essential regulators of… read more here.
Keywords: fusion; type iia; activin receptor; detection ... See more keywords
GW28-e1205 Activin receptor-like kinase 4 deficiency attenuates atrial remodeling and vulnerability to atrial fibrillation induced by pressure overload in mice
Sign Up to like & getrecommendations! Published in 2017 at "Journal of the American College of Cardiology"
DOI: 10.1016/j.jacc.2017.07.162
Abstract: Activin receptor-like kinase 4 (ALK4), a downstream receptor of transforming growth factor-β superfamily, is highly expressed in the mammal heart. We recently reported that ALK4 is upregulated in pressure-overloaded heart and ALK4 haplodeficiency attenuated the… read more here.
Keywords: pressure overload; like kinase; receptor like; activin receptor ... See more keywords
The activin receptor is stimulated in the skeleton, vasculature, heart, and kidney during chronic kidney disease.
Sign Up to like & getrecommendations! Published in 2018 at "Kidney international"
DOI: 10.1016/j.kint.2017.06.016
Abstract: We examined activin receptor type IIA (ActRIIA) activation in chronic kidney disease (CKD) by signal analysis and inhibition in mice with Alport syndrome using the ActRIIA ligand trap RAP-011 initiated in 75-day-old Alport mice. At… read more here.
Keywords: disease; ckd; mice; activin receptor ... See more keywords
Expression and anti-inflammatory role of activin receptor-interacting protein 2 in lipopolysaccharide-activated macrophages
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DOI: 10.1038/s41598-017-10855-4
Abstract: The bacterial endotoxin lipopolysaccharide (LPS), a key pathogenic stimulator, can induce the activation of macrophages. Activin receptor-interacting protein 2 (ARIP2), an intracellular signaling protein, has a wide histological distribution, however, whether ARIP2 is involved in… read more here.
Keywords: receptor interacting; anti inflammatory; inflammatory role; expression ... See more keywords
Establishment of primary chicken embryo myoblast cell culture, antigenic epitopes prediction and production of anti activin receptor type IIB polyclonal antibody in chicken.
Sign Up to like & getrecommendations! Published in 2021 at "Animal biotechnology"
DOI: 10.1080/10495398.2020.1870483
Abstract: The detection of activin receptor typeIIB (ACTRIIB) protein, a prominent negative muscle growth regulator has paramount value in augmenting growth traits through molecular breeding schemes in chicken. The study was formulated to establish primary chicken… read more here.
Keywords: chicken embryo; primary chicken; 18th day; activin receptor ... See more keywords
Kaempferol attenuates liver fibrosis by inhibiting activin receptor–like kinase 5
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular and Molecular Medicine"
DOI: 10.1111/jcmm.14528
Abstract: Liver fibrosis is a common public health problem. Patients with liver fibrosis are more likely to develop cirrhosis, or hepatocellular carcinoma (HCC) as a more serious consequence. Numerous therapeutic approaches have emerged, but the final… read more here.
Keywords: liver fibrosis; kinase; kaempferol; receptor like ... See more keywords
Abstract 5336: Discovery of a novel activin receptor-like kinases (ALKs) inhibitor targeting TGF-β signaling pathways
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-5336
Abstract: Introduction: Transforming growth factor β (TGF-β) plays a key role in promoting tumor progression mainly through facilitating angiogenesis, epithelial-mesenchymal transition (EMT) and also inducing immunosuppression in tumor microenvironment, allowing cancer cells to escape immune surveillance.… read more here.
Keywords: kinases alks; receptor like; activin receptor; like kinases ... See more keywords
Activin Receptor-Like Kinase 1 Combined With VEGF-A Affects Migration and Proliferation of Endothelial Cells From Sporadic Human Cerebral AVMs
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2018.00525
Abstract: Heterozygous loss of activin receptor-like kinase 1 (Alk1) can lead to hereditary hemorrhagic telangiectasia (HHT), which is a kind of vascular disease characterized by direct connections between arteries and veins with the lacking of capillaries,… read more here.
Keywords: cavm ecs; proliferation; migration; endothelial cells ... See more keywords
Endothelial Activin Receptor-Like Kinase 1 (ALK1) Regulates Myofibroblast Emergence and Peritubular Capillary Stability in the Early Stages of Kidney Fibrosis
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DOI: 10.3389/fphar.2022.843732
Abstract: Renal tubulo-interstitial fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) in the tubular interstitium during chronic kidney disease. The main source of ECM proteins are emerging and proliferating myofibroblasts. The sources of… read more here.
Keywords: kidney fibrosis; receptor like; activin receptor; alk1 ... See more keywords
Activin Receptor Ligand Blocking and Cancer Have Distinct Effects on Protein and Redox Homeostasis in Skeletal Muscle and Liver
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2018.01917
Abstract: Muscle wasting in cancer cachexia can be alleviated by blocking activin receptor type 2 (ACVR2) ligands through changes in protein synthesis/degradation. These changes in cellular and protein metabolism may alter protein homeostasis. First, we elucidated… read more here.
Keywords: skeletal muscle; muscle; muscle liver; activin receptor ... See more keywords
Endoglin and Activin Receptor-like Kinase 1 (Alk1) Modify Adrenomedullin Expression in an Organ-Specific Manner in Mice
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DOI: 10.3390/biology11030358
Abstract: Simple Summary Hereditary hemorrhagic telangiectasia (HHT) is called a rare disease because it affects relatively few people. It is characterized by malformations in some blood vessels and usually results in profuse nose bleedings. In a… read more here.
Keywords: disease; like kinase; receptor like; activin receptor ... See more keywords