Dentate gyrus activin signaling mediates the antidepressant response
Sign Up to like & getrecommendations! Published in 2021 at "Translational Psychiatry"
DOI: 10.1038/s41398-020-01156-y
Abstract: Antidepressants that target monoaminergic systems, such as selective serotonin reuptake inhibitors (SSRIs), are widely used to treat neuropsychiatric disorders including major depressive disorder, several anxiety disorders, and obsessive-compulsive disorder. However, these treatments are not ideal… read more here.
Keywords: activin signaling; response; dentate gyrus; antidepressant treatments ... See more keywords
Effect of Hesperidin against Induced Colon Cancer in Rats: Impact of Smad4 and Activin A Signaling Pathway.
Sign Up to like & getrecommendations! Published in 2021 at "Nutrition and cancer"
DOI: 10.1080/01635581.2021.1907424
Abstract: SCOPE To evaluate the chemopreventive efficacy of hesperidin (Hsd) in 1,2-dimethylhydrazine (DMH)-induced colorectal cancer (CRC) and demonstrate its role in mothers against decapentaplegic homolog 4(Smad4) and activin A signaling pathways. METHODS AND RESULTS A CRC… read more here.
Keywords: hsd; activin signaling; activin; smad4 activin ... See more keywords
Activin B signaling may promote the conversion of normal fibroblasts to scar fibroblasts
Sign Up to like & getrecommendations! Published in 2020 at "Medicine"
DOI: 10.1097/md.0000000000020253
Abstract: Abstract This study is to explore the molecular mechanism of benign bile duct hypertrophic scar formation. Differential proteins between the normal fibroblast (NFB) and scar fibroblast (SCFB) were screened by protein chip assay, and analyzed… read more here.
Keywords: act; tsp osm; activin signaling; expression act ... See more keywords
Inhibition of activin signaling in lung adenocarcinoma increases the therapeutic index of platinum chemotherapy
Sign Up to like & getrecommendations! Published in 2018 at "Science Translational Medicine"
DOI: 10.1126/scitranslmed.aat3504
Abstract: Inhibition of activin signaling enhances the efficacy and safety of platinum chemotherapy in lung adenocarcinoma models. Blocking activin actively treats cancer Platinum-based chemotherapy is a mainstay of treatment for lung cancer, but resistance to this… read more here.
Keywords: chemotherapy; platinum; activin signaling; resistance ... See more keywords
Intra‐epithelial non‐canonical Activin A signaling safeguards prostate progenitor quiescence
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Reports"
DOI: 10.15252/embr.202154049
Abstract: The healthy prostate is a relatively quiescent tissue. Yet, prostate epithelium overgrowth is a common condition during aging, associated with urinary dysfunction and tumorigenesis. For over thirty years, TGF‐β ligands have been known to induce… read more here.
Keywords: canonical activin; activin signaling; intra epithelial; quiescence ... See more keywords
Activin A Reduces GIRK Current to Excite Dentate Gyrus Granule Cells
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.920388
Abstract: Activin A, a member of the TGF-β family, is recognized as a multifunctional protein in the adult brain with a particular impact on neuronal circuits associated with cognitive and affective functions. Activin receptor signaling in… read more here.
Keywords: activin signaling; gyrus granule; activin; dentate gyrus ... See more keywords
Reducing the Excess Activin Signaling Rescues Muscle Degeneration in Myotonic Dystrophy Type 2 Drosophila Model
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Personalized Medicine"
DOI: 10.3390/jpm12030385
Abstract: Expanded non-coding RNA repeats of CCUG are the underlying genetic causes for myotonic dystrophy type 2 (DM2). There is an urgent need for effective medications and potential drug targets that may alleviate the progression of… read more here.
Keywords: activin signaling; drosophila model; muscle degeneration;