Synthesis, Anti-Plasmodial Activities, and Mechanistic Insights of 4-Aminoquinoline-Triazolopyrimidine Hybrids.
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DOI: 10.1021/acsmedchemlett.2c00078
Abstract: In the search of new antiplasmodial agents, a multitargeted approach was used in the synthesis of triazolopyrimidine- and 4-aminoquinolines-based hybrids. In vitro antiplasmodial evaluation on chloroquine-sensitive (3D7) and -resistant (W2) P. falciparum strains identified triazolopyrimidine-4-aminoquinoline… read more here.
Keywords: insights aminoquinoline; anti plasmodial; plasmodial activities; activities mechanistic ... See more keywords