Evaluation of the antiparasitic and antifungal activities of new synthetic piperlongumine-type cinnamide derivatives: booster effect by halogen substituents.
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DOI: 10.1002/cmdc.202300132
Abstract: A series of synthetic N-acylpyrrolidone and -piperidone derivatives of the natural alkaloid piperlongumine were prepared and tested for their activities against Leishmania major and Toxoplasma gondii parasites. Replacement of one of the aryl meta-methoxy groups… read more here.
Keywords: piperlongumine; antifungal activities; activities new; antiparasitic antifungal ... See more keywords
Synthesis, molecular docking, antiplasmodial and antioxidant activities of new sulfonamido-pepetide derivatives
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DOI: 10.1016/j.heliyon.2020.e04958
Abstract: Twenty-three new series of toluene-sulfonamide dipeptide derivatives were synthesized and screened for antiplasmodial and antioxidant potencies. Many of the derivatives were active against Plasmodium falciparum with IC50 ranging from 3.20 – 9.10 μM. The ability… read more here.
Keywords: antioxidant activities; activities new; antiplasmodial antioxidant; docking antiplasmodial ... See more keywords
Synthesis, characterization and in vitro antitrypanosomal activities of new carboxamides bearing quinoline moiety
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DOI: 10.1371/journal.pone.0191234
Abstract: The reported toxicities of current antitrypanosomal drugs and the emergence of drug resistant trypanosomes underscore the need for the development of new antitrypanosomal agents. We report herein the synthesis and antitrypanosomal activity of 24 new… read more here.
Keywords: antitrypanosomal activities; activities new; characterization vitro; new carboxamides ... See more keywords
Biological Activities of Some New Secondary Metabolites Isolated from Endophytic Fungi: A Review Study
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DOI: 10.3390/ijms22020959
Abstract: Secondary metabolites isolated from plant endophytic fungi have been getting more and more attention. Some secondary metabolites exhibit high biological activities, hence, they have potential to be used for promising lead compounds in drug discovery.… read more here.
Keywords: biological activities; new secondary; activities new; endophytic fungi ... See more keywords
Antioxidant and Antisteatotic Activities of a New Fucoidan Extracted from Ferula hermonis Roots Harvested on Lebanese Mountains
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DOI: 10.3390/molecules26041161
Abstract: Fucoidan is a fucose-rich sulfated polysaccharide with attractive therapeutic potential due to a variety of biological activities, including antioxidant action. Fucoidan is typically found in the cell wall of marine brown algae, but extra-algal sources… read more here.
Keywords: activities new; fucoidan; ferula hermonis; antioxidant antisteatotic ... See more keywords