D-1553: A novel KRASG12C inhibitor with potent and selective cellular and in vivo antitumor activity.
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DOI: 10.1111/cas.15829
Abstract: D-1553 is a small molecule inhibitor selectively targeting KRASG12C and currently in phase II clinical trials. Here, we report the preclinical data demonstrating antitumor activity of D-1553. Potency and specificity of D-1553 in inhibiting GDP-bound… read more here.
Keywords: antitumor activity; krasg12c; activity 1553; inhibitor ... See more keywords