An Activity‐Based Photosensitizer to Reverse Hypoxia and Oxidative Resistance for Tumor Photodynamic Eradication
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Materials"
DOI: 10.1002/adma.202206659
Abstract: Photodynamic therapy (PDT) has been a well‐accepted clinical treatment for malignant tumors owing to its noninvasiveness and high spatiotemporal selectivity. However, the treatment outcome of current PDT applications is hindered by hypoxia and intracellular oxidative… read more here.
Keywords: oxidative resistance; hypoxia; based photosensitizer; activity ... See more keywords
Thermodynamic activity‐based intrinsic enzyme kinetic sheds light on enzyme–solvent interactions
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Progress"
DOI: 10.1002/btpr.2401
Abstract: The reaction medium has major impact on biocatalytic reaction systems and on their economic significance. To allow for tailored medium engineering, thermodynamic phenomena, intrinsic enzyme kinetics, and enzyme–solvent interactions have to be discriminated. To this… read more here.
Keywords: enzyme solvent; thermodynamic activity; intrinsic enzyme; activity based ... See more keywords
STA‐55, an Easily Accessible, Broad‐Spectrum, Activity‐Based Aldehyde Dehydrogenase Probe
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.201900771
Abstract: Aldehyde dehydrogenases (ALDHs) convert aldehydes into carboxylic acids and are often upregulated in cancer. They have been linked to therapy resistance and are therefore potential therapeutic targets. However, only a few selective and potent inhibitors… read more here.
Keywords: probe; activity based; spectrum activity; broad spectrum ... See more keywords
Tagged Benzoxazin‐4‐Ones as Novel Activity‐Based Probes for Serine Proteases
Sign Up to like & getrecommendations! Published in 2021 at "ChemBioChem"
DOI: 10.1002/cbic.202000848
Abstract: Activity‐based probes (ABPs) are valuable chemical tools for profiling enzymes. They have been particularly useful in the study of proteases. ABPs rely on electrophilic scaffolds that covalently modify the target enzymes. Ideally, they can be… read more here.
Keywords: serine proteases; tagged benzoxazin; benzoxazin ones; activity based ... See more keywords
A Nucleophilic Activity‐Based Probe Enables Profiling of PLP‐Dependent Enzymes
Sign Up to like & getrecommendations! Published in 2023 at "ChemBioChem"
DOI: 10.1002/cbic.202200669
Abstract: PLP‐dependent enzymes represent an important class of highly “druggable” enzymes that perform a wide array of critical reactions to support all organisms. Inhibition of individual members of this family of enzymes has been validated as… read more here.
Keywords: dependent enzymes; plp dependent; nucleophilic activity; activity based ... See more keywords
A Diazaborine Activity‐Based Sensing Fluorescent Probe Reports Endogenously Produced Mitochondrial Peroxynitrite in Live Macrophages
Sign Up to like & getrecommendations! Published in 2025 at "ChemBioChem"
DOI: 10.1002/cbic.202400972
Abstract: We present the synthesis, properties, and imaging applications of a new class of diazaborine‐based probes (Peroxynitrite Probe‐1, PNP‐1) for selective peroxynitrite (ONOO−) imaging in live cells. PNP‐1 features a diazaborine‐based reaction motif that provides excellent… read more here.
Keywords: diazaborine activity; based sensing; peroxynitrite; activity based ... See more keywords
(Glycan Binding) Activity-Based Protein Profiling in Cells Enabled by Mass Spectrometry-Based Proteomics
Sign Up to like & getrecommendations! Published in 2023 at "Israel journal of chemistry"
DOI: 10.1002/ijch.202200097
Abstract: The presence of glycan modifications at the cell surface and other locales positions them as key regulators of cell recognition and function. However, due to the complexity of glycosylation, the annotation of which proteins bear… read more here.
Keywords: glycan binding; mass spectrometry; activity based; based protein ... See more keywords
Activity-based protein profiling - finding general solutions to specific problems.
Sign Up to like & getrecommendations! Published in 2023 at "Israel journal of chemistry"
DOI: 10.1002/ijch.202300029
Abstract: In this retrospective/perspective, I will share thoughts on developing and applying the activity-based protein profiling (ABPP) technology, an endeavor that has consumed much of our lab's attention over our 25+ year existence. Before doing so,… read more here.
Keywords: profiling finding; protein profiling; activity based; based protein ... See more keywords
Subanesthetic Ketamine Ameliorates Activity‐Based Anorexia of Adult Mice
Sign Up to like & getrecommendations! Published in 2025 at "Synapse"
DOI: 10.1002/syn.70005
Abstract: Anorexia nervosa (AN) is an eating disorder with the second highest mortality of all mental illnesses and high relapse rate, especially among adult females, yet with no accepted pharmacotherapy. A small number of studies have… read more here.
Keywords: based anorexia; ketamine ameliorates; activity based; subanesthetic ketamine ... See more keywords
Activity-Based Protein Profiling of Non-ribosomal Peptide Synthetases.
Sign Up to like & getrecommendations! Published in 2019 at "Current topics in microbiology and immunology"
DOI: 10.1007/82_2018_133
Abstract: Non-ribosomal peptide (NRP) natural products are one of the most promising resources for drug discovery and development because of their wide-ranging of therapeutic potential, and their behavior as virulence factors and signaling molecules. The NRPs… read more here.
Keywords: ribosomal peptide; based protein; nrps machinery; activity based ... See more keywords
Comparative Activity-Based Flavin-Dependent Oxidase Profiling.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6439-0_7
Abstract: Activity-based protein profiling (ABPP) has become a powerful chemoproteomic technology allowing for the dissection of complex ligand-protein interactions in their native cellular environment. One of the biggest challenges for ABPP is the extension of the… read more here.
Keywords: flavin dependent; comparative activity; activity based; dependent oxidase ... See more keywords