Altered TAOK2 activity causes autism-related neurodevelopmental and cognitive abnormalities through RhoA signaling
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Psychiatry"
DOI: 10.1038/s41380-018-0025-5
Abstract: Atypical brain connectivity is a major contributor to the pathophysiology of neurodevelopmental disorders (NDDs) including autism spectrum disorders (ASDs). TAOK2 is one of several genes in the 16p11.2 microdeletion region, but whether it contributes to… read more here.
Keywords: taok2; activity causes; taok2 activity; autism ... See more keywords
Absence or reduced Sox10 activity causes abnormal AS structures.
Sign Up to like & getrecommendations! Published in 2020 at "PLOS Genetics"
DOI: 10.1371/journal.pgen.1008774.s020
Abstract: (A-F) Ultrastructure analysis of the cornea (arrow) from sox10t3/+ or sox10+/+ sibling embryos (A-B, n = 2 embryos) and sox10t3/t3 homozygous mutants (C-F, n = 4). Low magnification overviews (A, C and E) and respective… read more here.
Keywords: activity causes; corneal endothelium; sox10 activity; endothelial cells ... See more keywords