Potent inhibitory activity of Taniborbactam towards NDM-1 and NDM-1Q119X mutants, and "in vitro" activity of cefepime/taniborbactam against MBLsproducing Enterobacterales.
Sign Up to like & getrecommendations! Published in 2020 at "International journal of antimicrobial agents"
DOI: 10.1016/j.ijantimicag.2020.106228
Abstract: The main goal of the present study was to investigate the "in vitro" activity of taniborbactam (VNRX-5133), a novel broad-spectrum bicyclic boronate, against NDM-1 and Q119E, Q119K, Q119C, Q119F, Q119V and Q119Y NDM-1 variants which… read more here.
Keywords: taniborbactam; vitro activity; activity taniborbactam; activity cefepime ... See more keywords
In Vitro Activity of Cefepime-Taniborbactam and Comparators against Clinical Isolates of Gram-Negative Bacilli from 2018 to 2020: Results from the Global Evaluation of Antimicrobial Resistance via Surveillance (GEARS) Program
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DOI: 10.1128/aac.01281-22
Abstract: Taniborbactam is a novel cyclic boronate β-lactamase inhibitor in clinical development in combination with cefepime. We assessed the in vitro activity of cefepime-taniborbactam and comparators against a 2018–2020 collection of Enterobacterales (n = 13,731) and Pseudomonas aeruginosa… read more here.
Keywords: activity cefepime; vitro activity; taniborbactam; cefepime taniborbactam ... See more keywords
In Vitro Activity of Cefepime-Taniborbactam against Carbapenemase-Producing Enterobacterales and Pseudomonas aeruginosa Isolates Recovered in Spain
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DOI: 10.1128/aac.02161-21
Abstract: Novel β-lactam–β-lactamase inhibitor combinations currently approved for clinical use are poorly active against metallo-β-lactamase (MBL)-producing strains. We evaluated the in vitro activity of cefepime-taniborbactam (FTB [formerly cefepime–VNRX-5133]) and comparator agents against carbapenemase-producing Enterobacterales (n = 247) and… read more here.
Keywords: vitro activity; cefepime taniborbactam; producing enterobacterales; activity cefepime ... See more keywords