Antiviral Activity of Cell Membrane-Bound Amphiphilic Polymers
Sign Up to like & getrecommendations! Published in 2023 at "Langmuir"
DOI: 10.1021/acs.langmuir.3c00054
Abstract: We demonstrate that cholesterol-modified polyethylene glycol has antiviral activity, exerted by anchoring to plasma membranes and sterically inhibiting viruses from entering cells. These polymers distribute sparsely on cell membranes even at binding saturation. However, the… read more here.
Keywords: activity cell; cell; cell membrane; membrane bound ... See more keywords
Synthesis and Activity of T-Cell Tumor-Directing MegaMolecules.
Sign Up to like & getrecommendations! Published in 2024 at "Journal of the American Chemical Society"
DOI: 10.1021/jacs.4c07377
Abstract: This paper describes the synthesis, characterization, and functional activity of 26 MegaMolecule-based bispecific antibody mimics for T-cell redirection toward HER2+ cancer cells. The work reports functional bispecific MegaMolecules that bind both receptor targets, and recruit… read more here.
Keywords: activity cell; tumor; synthesis activity; antibody mimics ... See more keywords
Regulation of local GTP availability controls RAC1 activity and cell invasion.
Sign Up to like & getrecommendations! Published in 2021 at "Nature communications"
DOI: 10.1038/s41467-021-26324-6
Abstract: Physiological changes in GTP levels in live cells have never been considered a regulatory step of RAC1 activation because intracellular GTP concentration (determined by chromatography or mass spectrometry) was shown to be substantially higher than… read more here.
Keywords: activity cell; rac1 activity; gtp levels; gtp ... See more keywords