Cellular mechanisms mediating activity‐dependent extracellular space shrinkage in the retina
Sign Up to like & getrecommendations! Published in 2022 at "Glia"
DOI: 10.1002/glia.24228
Abstract: Volume transmission plays an essential role in CNS function, with neurotransmitters released from synapses diffusing through the extracellular space (ECS) to distant sites. Changes in the ECS volume fraction (α) will influence the diffusion and… read more here.
Keywords: activity dependent; volume; extracellular space; activity ... See more keywords
Activity-Dependent Photoaffinity Labeling of Metalloproteases.
Sign Up to like & getrecommendations! Published in 2017 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-6439-0_8
Abstract: Metalloproteases, notably members of the matrix metalloprotease (MMP) and A Disintegrin And Metalloprotease (ADAM) families play crucial roles in tissue remodeling, the liberation of growth factors and cytokines from cell membranes (shedding) and cell-cell or… read more here.
Keywords: dependent photoaffinity; cell; activity; photoaffinity labeling ... See more keywords
Subcellular Optogenetic Stimulation Platform for Studying Activity-Dependent Axon Myelination In Vitro.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7862-5_16
Abstract: Activity-dependent myelination modulates neuron conduction velocity and as such it is essential for a correct wiring of a whole nervous system. Increasing myelination through inducing neuron activity has been proposed as a treatment strategy for… read more here.
Keywords: stimulation; myelination; platform; studying activity ... See more keywords
Activity-dependent development of GABAergic synapses
Sign Up to like & getrecommendations! Published in 2019 at "Brain Research"
DOI: 10.1016/j.brainres.2018.11.014
Abstract: In the brain, dendrites of pyramidal neurons contain intermingled excitatory and inhibitory synapses. Synaptic connections dynamically change during development and throughout our lifetime, yet the brain can properly maintain an optimal ratio of synaptic excitation… read more here.
Keywords: dependent development; gabaergic synapses; activity dependent; activity ... See more keywords
Activity-Dependent Netrin-1 Secretion Drives Synaptic Insertion of GluA1-Containing AMPA Receptors in the Hippocampus.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.09.028
Abstract: Dynamic trafficking of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid glutamate receptors (AMPARs) to synapses is critical for activity-dependent synaptic plasticity underlying learning and memory, but the identity of key molecular effectors remains elusive. Here, we demonstrate that membrane depolarization… read more here.
Keywords: netrin secretion; glua1 containing; dependent netrin; activity ... See more keywords
The Probability of Neurotransmitter Release Governs AMPA Receptor Trafficking via Activity-Dependent Regulation of mGluR1 Surface Expression
Sign Up to like & getrecommendations! Published in 2018 at "Cell Reports"
DOI: 10.1016/j.celrep.2018.12.010
Abstract: A major mechanism contributing to synaptic plasticity involves alterations in the number of AMPA receptors (AMPARs) expressed at synapses. Hippocampal CA1 synapses, where this process has been most extensively studied, are highly heterogeneous with respect… read more here.
Keywords: probability neurotransmitter; mglur1; neurotransmitter release; activity ... See more keywords
Fatigue and activity-dependent conduction block in neuromuscular disorders
Sign Up to like & getrecommendations! Published in 2022 at "Clinical Neurophysiology Practice"
DOI: 10.1016/j.cnp.2022.02.003
Abstract: Highlights • Demyelination and increased axonal branching reduce the safety factor for impulse transmission.• Axonal hyperpolarization induced by voluntary contraction result in conduction block, and thereby fatigue in CIDP/SBMA patients.• Activity-dependent conduction block causes peripheral… read more here.
Keywords: conduction; conduction block; dependent conduction; activity dependent ... See more keywords
ADNP (Activity Dependent Neuroprotector Homeobox): A novel oncogene driving poor prognosis in high-grade serous carcinoma
Sign Up to like & getrecommendations! Published in 2020 at "EBioMedicine"
DOI: 10.1016/j.ebiom.2019.11.050
Abstract: In this issue of EBioMedicine, Gatza and colleagues show through an integrative proteogenomic analysis of publicly available datasets that amplification and overexpression of ADNP (Activity Dependent Neuroprotector Homeobox) are associated with poor prognosis in high-grade… read more here.
Keywords: carcinoma; poor prognosis; adnp activity; prognosis ... See more keywords
Activity-Dependent Downscaling of Subthreshold Synaptic Inputs during Slow-Wave-Sleep-like Activity In Vivo
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DOI: 10.1016/j.neuron.2018.01.047
Abstract: Summary Activity-dependent synaptic plasticity is critical for cortical circuit refinement. The synaptic homeostasis hypothesis suggests that synaptic connections are strengthened during wake and downscaled during sleep; however, it is not obvious how the same plasticity… read more here.
Keywords: like activity; activity; wave sleep; slow wave ... See more keywords
Activity-Regulated Transcription: Bridging the Gap between Neural Activity and Behavior
Sign Up to like & getrecommendations! Published in 2018 at "Neuron"
DOI: 10.1016/j.neuron.2018.10.013
Abstract: Gene transcription is the process by which the genetic codes of organisms are read and interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As cells function in their respective… read more here.
Keywords: transcription; transcription bridging; regulated transcription; activity regulated ... See more keywords
Activity-dependent Signaling and Epigenetic Abnormalities in Mice Exposed to Postnatal Ethanol
Sign Up to like & getrecommendations! Published in 2018 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2018.07.011
Abstract: Postnatal ethanol exposure has been shown to cause persistent defects in hippocampal synaptic plasticity and disrupt learning and memory processes. However, the mechanisms responsible for these abnormalities are less well studied. We evaluated the influence… read more here.
Keywords: signaling epigenetic; postnatal ethanol; ethanol; dependent signaling ... See more keywords