Probenecid increases renal retention and antitumor activity of DFMO in neuroblastoma
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DOI: 10.1007/s00280-021-04309-y
Abstract: Neuroblastoma (NB) is the most common extracranial solid tumor in children. Interference with the polyamine biosynthesis pathway by inhibition of MYCN-activated ornithine decarboxylase (ODC) is a validated approach. The ODC inhibitor α-difluoromethylornithine (DFMO, or Eflornithine)… read more here.
Keywords: probenecid; activity dfmo; dfmo; antitumor activity ... See more keywords