Unveiling the enzymatic activity of a dimeric LDH isoform and its implications for allosteric inhibition strategies
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DOI: 10.1002/pro.70367
Abstract: Lactate dehydrogenase (LDH) is a key enzyme in cancer metabolism, with isoforms LDH5 and LDH1 supporting glycolysis and oxidative lactate metabolism, respectively. While the development of competitive LDH inhibitors has faced diverse challenges, allosteric strategies… read more here.
Keywords: ldh; tetramerization; unveiling enzymatic; activity ... See more keywords
Antimicrobial activity of dimeric acylphloroglucinols isolated from southern Brazilian Hypericum species against to resistant bacterial
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DOI: 10.1080/14786419.2022.2038596
Abstract: Abstract The hexanic extracts of Hypericum austrobrasiliense, H. caprifoliatum, H. denudatum, H. pedersenii and H. polyanthemum, and three isolated dimeric acylphloroglucinols (uliginosin B, japonicine A and hyperbrasilol B) were assayed for their antimicrobial activity against… read more here.
Keywords: antimicrobial activity; isolated southern; activity dimeric; activity ... See more keywords
Antileishmanial Activity of Dimeric Flavonoids Isolated from Arrabidaea brachypoda
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DOI: 10.3390/molecules24010001
Abstract: Leishmaniasis are diseases caused by parasites belonging to Leishmania genus. The treatment with pentavalent antimonials present high toxicity. Secondary line drugs, such as amphotericin B and miltefosine also have a narrow therapeutic index. Therefore, there… read more here.
Keywords: arrabidaea brachypoda; antileishmanial activity; dimeric flavonoids; compound ... See more keywords