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Published in 2017 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2012.11.021
Abstract: Abstract The antimicrobial activity of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines was correlated with their physicochemical parameters using Hansch analysis for first time. The QSAR models were developed by both linear and multiple linear regression and the developed models were…
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Keywords:
antimicrobial activity;
disubstituted naphtho;
naphtho oxazines;
qsar studies ... See more keywords
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Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.01.012
Abstract: A series of novel 9, 13-disubstituted berberine derivatives have been synthesized and evaluated for the antibacterial activities against Staphylococcus aureus, including Newman strain and multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108, and NRS-271). Compound 20 shows…
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Keywords:
berberine derivatives;
disubstituted berberine;
synthesis antistaphylococcal;
antistaphylococcal activity ... See more keywords
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Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.037
Abstract: An efficient synthetic route for the synthesis of 2H-pyrazolo[4,3-c]pyridines, primarily varying by the substituents at the 2-, 4- and 6-positions, is described here. A Sonogashira-type cross-coupling reaction was employed to yield 3-alkynyl-1H-pyrazole-4-carbaldehydes, ethanones and propanones…
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Keywords:
anti mitotic;
pyrazolo pyridines;
synthesis anti;
mitotic activity ... See more keywords
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Published in 2020 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2020.00433
Abstract: The appearance of drug-resistant strains of Mycobacterium tuberculosis and the dramatic increase in infection rates worldwide evidences the urgency of developing new and effective compounds for treating tuberculosis. Benzimidazoles represent one possible source of new…
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Keywords:
antimycobacterial activity;
trisubstituted benzimidazoles;
activity disubstituted;
tuberculosis ... See more keywords
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Published in 2020 at "Molecules"
DOI: 10.3390/molecules25020299
Abstract: In order to prepare, at low cost, new compounds active against Plasmodium falciparum, and with a less side-effects, we have designed and synthesized a library of 1,4-disubstituted piperidine derivatives from 4-aminopiperidine derivatives 6. The resulting…
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Keywords:
synthesis antimalarial;
piperidine derivatives;
antimalarial activity;
disubstituted piperidine ... See more keywords