QSAR studies of antimicrobial activity of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines using topological descriptors
Sign Up to like & getrecommendations! Published in 2017 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2012.11.021
Abstract: Abstract The antimicrobial activity of 1,3-disubstituted-1H-naphtho[1,2-e][1,3]oxazines was correlated with their physicochemical parameters using Hansch analysis for first time. The QSAR models were developed by both linear and multiple linear regression and the developed models were… read more here.
Keywords: antimicrobial activity; disubstituted naphtho; naphtho oxazines; qsar studies ... See more keywords
The synthesis and antistaphylococcal activity of 9, 13-disubstituted berberine derivatives.
Sign Up to like & getrecommendations! Published in 2017 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.01.012
Abstract: A series of novel 9, 13-disubstituted berberine derivatives have been synthesized and evaluated for the antibacterial activities against Staphylococcus aureus, including Newman strain and multidrug-resistant strains (NRS-1, NRS-70, NRS-100, NRS-108, and NRS-271). Compound 20 shows… read more here.
Keywords: berberine derivatives; disubstituted berberine; synthesis antistaphylococcal; antistaphylococcal activity ... See more keywords
Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2018.03.037
Abstract: An efficient synthetic route for the synthesis of 2H-pyrazolo[4,3-c]pyridines, primarily varying by the substituents at the 2-, 4- and 6-positions, is described here. A Sonogashira-type cross-coupling reaction was employed to yield 3-alkynyl-1H-pyrazole-4-carbaldehydes, ethanones and propanones… read more here.
Keywords: anti mitotic; pyrazolo pyridines; synthesis anti; mitotic activity ... See more keywords
Synthesis and Antimycobacterial Activity of 2,5-Disubstituted and 1,2,5-Trisubstituted Benzimidazoles
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2020.00433
Abstract: The appearance of drug-resistant strains of Mycobacterium tuberculosis and the dramatic increase in infection rates worldwide evidences the urgency of developing new and effective compounds for treating tuberculosis. Benzimidazoles represent one possible source of new… read more here.
Keywords: antimycobacterial activity; trisubstituted benzimidazoles; activity disubstituted; tuberculosis ... See more keywords
Spasmolytic Activity of 1,3-Disubstituted 3,4-Dihydroisoquinolines
Sign Up to like & getrecommendations! Published in 2024 at "Biomedicines"
DOI: 10.3390/biomedicines12071556
Abstract: This article concerns the spasmolytic activities of some novel 1,3-disubstituted 3,4-dihydroisoquinolines. These compounds can be evaluated as potential therapeutic candidates according to Lipinski’s rule of five, showing high gastrointestinal absorption and the ability to cross… read more here.
Keywords: spasmolytic activity; activity disubstituted; smooth muscle; disubstituted dihydroisoquinolines ... See more keywords
Synthesis and Antimalarial Activity of 1,4-Disubstituted Piperidine Derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Molecules"
DOI: 10.3390/molecules25020299
Abstract: In order to prepare, at low cost, new compounds active against Plasmodium falciparum, and with a less side-effects, we have designed and synthesized a library of 1,4-disubstituted piperidine derivatives from 4-aminopiperidine derivatives 6. The resulting… read more here.
Keywords: synthesis antimalarial; piperidine derivatives; antimalarial activity; disubstituted piperidine ... See more keywords