The Discovery and Structure-Activity Evaluation of (+)-Floyocidin B and Synthetic Analogs.
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100644
Abstract: Tuberculosis represents one of the ten most common courses of death worldwide and the emergence of multidrug-resistant M. tuberculosis makes the discovery of novel anti-tuberculosis active structures an urgent priority. Here, we show that (+)-floyocidin… read more here.
Keywords: activity evaluation; structure activity; structure; floyocidin ... See more keywords
Biological activity evaluation and computational study of novel triazene derivatives containing benzothiazole rings
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.129507
Abstract: Abstract Three new triazene compounds namely, (E)-2-(3-(p-tolyl)triaz-1-en-1-yl)benzo[d]thiazole (L1), (E)-1-(4-(3-(benzo[d]thiazol-2-yl)triaz-2-en-1-yl)phenyl)ethan-1-one (L2), and (E)-2-(3-(4-nitrophenyl)triaz-1-en-1-yl)benzo[d]thiazole (L3) having the general structure R1-N=N-NH-R2 have been synthesized by diazo-coupling reaction. The synthesized compounds were characterized using different spectroscopic techniques such as… read more here.
Keywords: biological activity; triazene; computational study; activity evaluation ... See more keywords
Synthesis and biological activity evaluation of dolastatin 10 analogues with N-terminal modifications
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DOI: 10.1016/j.tet.2017.03.006
Abstract: Abstract We have described the synthesis of the two complex units (2 R ,3 R ,4 S )-dolaproine (Dap) and (3 R ,4 S ,5 S )-dolaisoleuine (Dil) of dolastatin 10 from natural amino acids.… read more here.
Keywords: biological activity; dolastatin analogues; activity evaluation; terminal modifications ... See more keywords
Design, synthesis and antiproliferative activity evaluation of fluorine-containing chalcone derivatives
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DOI: 10.1080/07391102.2020.1848627
Abstract: Abstract A series of new chalcones containing fluoro atom at B ring have been designed, synthesized, and evaluated to be antiproliferative activity against a panel of human tumor cell lines. Some of the analogs (8,… read more here.
Keywords: activity evaluation; synthesis antiproliferative; design synthesis; activity ... See more keywords
P304 Leucine-rich alpha 2 glycoprotein reduces the necessity for endoscopic examination for activity evaluation
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjac190.0434
Abstract: Leucine-rich alpha 2 glycoprotein (LRG) reflects mucosal healing in ulcerative colitis (UC) and is useful for assessing mucosal healing. In this study, we hypothesized that endoscopy for activity evaluation may be unnecessary depending on LRG… read more here.
Keywords: leucine rich; activity evaluation; remission; lrg ... See more keywords
Antioxidant activity evaluation of rosemary ethanol extract and their cellular antioxidant activity toward HeLa cells.
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DOI: 10.1111/jfbc.12851
Abstract: Rosemary ethanol extract (REE) from Rosmarinus officinalis was identified by LC-ESI-MS/MS and 12 compounds were found. Among them, rosmarinic acid (389.78 μg/mg in REE), luteolin-3'-O-glucuronide (325.58 μg/mg), luteolin-5-O-glucuronide (120.92 μg/mg), and geniposide (120.83 μg/mg) are the major components. The… read more here.
Keywords: activity evaluation; cellular antioxidant; antioxidant activity; hela cells ... See more keywords
Synthesis and biological activity evaluation of pyrazole-1,2,4-triazole hybrids: A computer-aided docking studies.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug discovery technologies"
DOI: 10.2174/1570163820666221125121625
Abstract: AIMS/BACKGROUND In the present study, a new series of 1,2,4-triazole linked to pyrazole derivatives (8a-j) of 4-(((7-amino-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-6-yl)methyl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one were synthesized and assessed for their antibacterial and anticancer activity. OBJECTIVE Encouraged by these results, these analogues 4-(((7-amino-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-6-yl)methyl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-ones… read more here.
Keywords: synthesis biological; activity evaluation; biological activity; activity ... See more keywords
Isolation, identification and antagonistic activity evaluation of actinomycetes in barks of nine trees
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DOI: 10.2298/abs160429109w
Abstract: Actinomycetes are important producers of novel bioactive compounds. New sources need to be explored for isolating previously unknown bioactive compound-producing actinomycetes. Here we evaluated the potential of bark as a natural source of novel bioactive… read more here.
Keywords: identification antagonistic; isolation identification; evaluation actinomycetes; activity evaluation ... See more keywords
Synthesis and Antimicrobial Activity Evaluation of Some Novel Heterocycles Derived from Chromonyl-2(3H)-furanone
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DOI: 10.3184/174751918x15295796734379
Abstract: 6-Chloro-3-((2-oxo-5-phenylfuran-3(2H)-ylidene)methyl)-4H-chromen-4-one was utilised for the construction of N-heterocycles. The proclivity of this furanone towards some nitrogen nucleophiles, i.e. glycine, thiosemicarbazide, thiocarbohydrazide, phenylhydrazine and o-phenylenediamine, was studied. The structures of all products obtained were established on… read more here.
Keywords: evaluation novel; antimicrobial activity; novel heterocycles; activity evaluation ... See more keywords
Activity Evaluation Methodology for the Disposed Medical Linear Accelerators
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DOI: 10.3390/app13010528
Abstract: For the medical linear accelerators (linac) that utilize more than 10 MV of photon energy, components inside the linac head become radioactivate during the 10–15-year operating cycle. Prior to disposal, radioactive waste must be evaluated… read more here.
Keywords: medical linear; activity evaluation; linear accelerators; methodology ... See more keywords
Physical Activity Evaluation Using Activity Trackers for Type 2 Diabetes Prevention in Patients with Prediabetes
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Environmental Research and Public Health"
DOI: 10.3390/ijerph19148251
Abstract: Background: Prediabetes is a reversible condition, but lifestyle-changing measures, such as increasing physical activity, should be taken. This article explores the use of Fitbit activity trackers to assess physical activity and its impact on prediabetic… read more here.
Keywords: activity evaluation; physical activity; activity variability; activity ... See more keywords