The Discovery and Structure-Activity Evaluation of (+)-Floyocidin B and Synthetic Analogs.
Sign Up to like & getrecommendations! Published in 2021 at "ChemMedChem"
DOI: 10.1002/cmdc.202100644
Abstract: Tuberculosis represents one of the ten most common courses of death worldwide and the emergence of multidrug-resistant M. tuberculosis makes the discovery of novel anti-tuberculosis active structures an urgent priority. Here, we show that (+)-floyocidin… read more here.
Keywords: activity evaluation; structure activity; structure; floyocidin ... See more keywords
Biological activity evaluation and computational study of novel triazene derivatives containing benzothiazole rings
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2020.129507
Abstract: Abstract Three new triazene compounds namely, (E)-2-(3-(p-tolyl)triaz-1-en-1-yl)benzo[d]thiazole (L1), (E)-1-(4-(3-(benzo[d]thiazol-2-yl)triaz-2-en-1-yl)phenyl)ethan-1-one (L2), and (E)-2-(3-(4-nitrophenyl)triaz-1-en-1-yl)benzo[d]thiazole (L3) having the general structure R1-N=N-NH-R2 have been synthesized by diazo-coupling reaction. The synthesized compounds were characterized using different spectroscopic techniques such as… read more here.
Keywords: biological activity; triazene; computational study; activity evaluation ... See more keywords
Synthesis and biological activity evaluation of dolastatin 10 analogues with N-terminal modifications
Sign Up to like & getrecommendations! Published in 2017 at "Tetrahedron"
DOI: 10.1016/j.tet.2017.03.006
Abstract: Abstract We have described the synthesis of the two complex units (2 R ,3 R ,4 S )-dolaproine (Dap) and (3 R ,4 S ,5 S )-dolaisoleuine (Dil) of dolastatin 10 from natural amino acids.… read more here.
Keywords: biological activity; dolastatin analogues; activity evaluation; terminal modifications ... See more keywords
Design, Synthesis, and Activity Evaluation of C-23-Modified 5-O-Mycaminosyltylonolide Derivatives.
Sign Up to like & getrecommendations! Published in 2024 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.4c00458
Abstract: The widespread use of tylosin family drugs in clinical practice has led to bacterial resistance and reduced therapeutic efficacy. We designed and synthesized a series of new semisynthetic derivatives of tylosin with 5-O-mycaminosyltylonolide as the… read more here.
Keywords: antibacterial activity; activity evaluation; synthesis activity; design synthesis ... See more keywords
Discovery of a New Class of Thiazolidin-4-one-Based Inhibitors of Human Dihydroorotate Dehydrogenase: Biological Activity Evaluation, Molecular Docking, and Molecular Dynamics
Sign Up to like & getrecommendations! Published in 2025 at "ACS Omega"
DOI: 10.1021/acsomega.4c11459
Abstract: The continuous outbreak of various viruses reminds us to prepare broad-spectrum antiviral drugs. Human dihydroorotate dehydrogenase (hDHODH) inhibitor exhibits broad-spectrum antiviral effects. In order to explore the novel type of human dihydroorotate dehydrogenase inhibitor (hDHODHi),… read more here.
Keywords: molecular docking; biological activity; activity evaluation; dihydroorotate dehydrogenase ... See more keywords
Design, synthesis and antiproliferative activity evaluation of fluorine-containing chalcone derivatives
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2020.1848627
Abstract: Abstract A series of new chalcones containing fluoro atom at B ring have been designed, synthesized, and evaluated to be antiproliferative activity against a panel of human tumor cell lines. Some of the analogs (8,… read more here.
Keywords: activity evaluation; synthesis antiproliferative; design synthesis; activity ... See more keywords
P304 Leucine-rich alpha 2 glycoprotein reduces the necessity for endoscopic examination for activity evaluation
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Crohn's and Colitis"
DOI: 10.1093/ecco-jcc/jjac190.0434
Abstract: Leucine-rich alpha 2 glycoprotein (LRG) reflects mucosal healing in ulcerative colitis (UC) and is useful for assessing mucosal healing. In this study, we hypothesized that endoscopy for activity evaluation may be unnecessary depending on LRG… read more here.
Keywords: leucine rich; activity evaluation; remission; lrg ... See more keywords
Antioxidant activity evaluation of rosemary ethanol extract and their cellular antioxidant activity toward HeLa cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of food biochemistry"
DOI: 10.1111/jfbc.12851
Abstract: Rosemary ethanol extract (REE) from Rosmarinus officinalis was identified by LC-ESI-MS/MS and 12 compounds were found. Among them, rosmarinic acid (389.78 μg/mg in REE), luteolin-3'-O-glucuronide (325.58 μg/mg), luteolin-5-O-glucuronide (120.92 μg/mg), and geniposide (120.83 μg/mg) are the major components. The… read more here.
Keywords: activity evaluation; cellular antioxidant; antioxidant activity; hela cells ... See more keywords
Optimized expression of oxazolomycins in engineered Streptomyces longshengensis and their activity evaluation
Sign Up to like & getrecommendations! Published in 2025 at "Microbial Cell Factories"
DOI: 10.1186/s12934-025-02726-9
Abstract: To cope with the growing number of severe diseases and intractable pathogens, drug innovation in both chemical structures and pharmacological efficiency has become an imperative global mission. Oxazolomycins are a unique family of polyketide-polypeptide antibiotics… read more here.
Keywords: streptomyces longshengensis; activity evaluation; longshengensis; toxa5 ... See more keywords
Catalytic activity evaluation of phyto synthesized SrO and chitosan encapsulated SrO nanomaterials
Sign Up to like & getrecommendations! Published in 2025 at "PLOS One"
DOI: 10.1371/journal.pone.0328646
Abstract: Industrial wastewater contaminated with organic dyes poses significant environmental and health risks. Developing effective and eco-friendly removal methods is crucial to mitigate the harmful impact of dye pollution. This study explores the green synthesis and… read more here.
Keywords: chitosan encapsulated; sro nanocomposite; sro nanoparticles; catalytic activity ... See more keywords
Synthesis and biological activity evaluation of pyrazole-1,2,4-triazole hybrids: A computer-aided docking studies.
Sign Up to like & getrecommendations! Published in 2022 at "Current drug discovery technologies"
DOI: 10.2174/1570163820666221125121625
Abstract: AIMS/BACKGROUND In the present study, a new series of 1,2,4-triazole linked to pyrazole derivatives (8a-j) of 4-(((7-amino-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-6-yl)methyl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-one were synthesized and assessed for their antibacterial and anticancer activity. OBJECTIVE Encouraged by these results, these analogues 4-(((7-amino-7H-[1,2,4]triazolo[4,3-b][1,2,4]triazol-6-yl)methyl)amino)-1,5-dimethyl-2-phenyl-1H-pyrazol-3(2H)-ones… read more here.
Keywords: synthesis biological; activity evaluation; biological activity; activity ... See more keywords