Facile and sensitive S1 endonuclease activity and inhibition assay using positively-charged Ag nanorods
Sign Up to like & getrecommendations! Published in 2019 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2018.11.017
Abstract: Abstract In this work, we designed a facile and promising strategy for fluorescence determination of S1 endonuclease activity and inhibition based on fluorescence resonance energy transfer (FRET) between positively Ag nanorods (AgNRs) and negatively-charged ROX-labeled… read more here.
Keywords: endonuclease; fluorescence; rox ssdna; activity inhibition ... See more keywords
A Direct Assay for Measuring the Activity and Inhibition of Coactivator-Associated Arginine Methyltransferase 1
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00075
Abstract: Coactivator-associated arginine methyltransferase 1 (CARM1) is a member of the family of protein arginine methyltransferases. CARM1 catalyzes methyl group transfer from the cofactor S-adenosyl-l-methionine (AdoMet) to both histone and nonhistone protein substrates. CARM1 is involved… read more here.
Keywords: activity inhibition; coactivator associated; arginine methyltransferase; carm1 ... See more keywords
Insights into activity and inhibition from the crystal structure of human O-GlcNAcase.
Sign Up to like & getrecommendations! Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2357
Abstract: O-GlcNAc hydrolase (OGA) catalyzes removal of βα-linked N-acetyl-D-glucosamine from serine and threonine residues. We report crystal structures of Homo sapiens OGA catalytic domain in apo and inhibited states, revealing a flexible dimer that displays three… read more here.
Keywords: crystal structure; activity inhibition; inhibition crystal; structure human ... See more keywords
Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA
Sign Up to like & getrecommendations! Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab513
Abstract: Abstract The rnlAB toxin-antitoxin operon from Escherichia coli functions as an anti-phage defense system. RnlA was identified as a member of the HEPN (Higher Eukaryotes and Prokaryotes Nucleotide-binding domain) superfamily of ribonucleases. The activity of… read more here.
Keywords: hepn; required activity; rnla; canonical hepn ... See more keywords
In vitro biomedical corrosion and enzyme activity inhibition on modified Cu-Zn-Al bioalloy
Sign Up to like & getrecommendations! Published in 2023 at "Corrosion Reviews"
DOI: 10.1515/corrrev-2022-0025
Abstract: Abstract The amperometric biosensor was created using a flat sheet of the Cu-Zn-Al shape memory alloy, with a shiny surface and uniform thickness below 1 mm. The high biocompatibility and a large specific surface area… read more here.
Keywords: activity inhibition; vitro biomedical; enzyme activity; biomedical corrosion ... See more keywords
Label-Free Assay of Protein Kinase A Activity and Inhibition Using a Peptide-Based Electrochemical Sensor
Sign Up to like & getrecommendations! Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9040423
Abstract: We propose a simple label-free electrochemical biosensor for monitoring protein kinase activity and inhibition using a peptide-modified electrode. The biosensor employs cys-kemptide (CLRRASLG) as a substrate peptide which was immobilized on the surface of a… read more here.
Keywords: activity inhibition; sensor; activity; protein kinase ... See more keywords
MPP+-Induced Changes in Cellular Impedance as a Measure for Organic Cation Transporter (SLC22A1-3) Activity and Inhibition
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031203
Abstract: The organic cation transporters OCT1-3 (SLC22A1-3) facilitate the transport of cationic endo- and xenobiotics and are important mediators of drug distribution and elimination. Their polyspecific nature makes OCTs highly susceptible to drug–drug interactions (DDIs). Currently,… read more here.
Keywords: activity inhibition; transport; activity; impedance ... See more keywords
Effects of Phosphorylation on the Activity, Inhibition and Stability of Carbonic Anhydrases
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119275
Abstract: Carbonic anhydrases (CAs) are a metalloenzyme family that have important roles in cellular processes including pH homeostasis and have been implicated in multiple pathological conditions. Small molecule inhibitors have been developed to target carbonic anhydrases,… read more here.
Keywords: carbonic anhydrases; effects phosphorylation; activity inhibition; phosphorylation ... See more keywords
Structural Activity and HAD Inhibition Efficiency of Pelargonidin and Its Glucoside—A Theoretical Approach
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27228016
Abstract: Anthocyanins are an important pharmaceutical ingredient possessing diet regulatory, antioxidant, anticancer, antidiabetic, anti-obesity, antimicrobial, and anti-inflammatory properties. Pelargonidin is an important anthocyanin-based orange-red flavonoid compound used in drugs for treating hypoglycemia, retinopathy, skeletal myopathy, etc.… read more here.
Keywords: efficiency pelargonidin; activity inhibition; structural activity; pelargonidin ... See more keywords
Development, validation and application of a liquid chromatography-tandem mass spectrometry method for the activity and inhibition of DPP-4.
Sign Up to like & getrecommendations! Published in 2022 at "Bioanalysis"
DOI: 10.4155/bio-2022-0004
Abstract: Background: Inhibition of the enzyme dipeptidyl peptidase 4 (DPP-4) is a pharmaceutical treatment for type 2 diabetes. To demonstrate bioequivalence of enzyme inhibition of a new dosage form of the inhibitor vildagliptin, a method for… read more here.
Keywords: inhibition dpp; activity inhibition; inhibition; method ... See more keywords