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Published in 2019 at "Chinese Chemical Letters"
DOI: 10.1016/j.cclet.2018.11.017
Abstract: Abstract In this work, we designed a facile and promising strategy for fluorescence determination of S1 endonuclease activity and inhibition based on fluorescence resonance energy transfer (FRET) between positively Ag nanorods (AgNRs) and negatively-charged ROX-labeled…
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Keywords:
endonuclease;
fluorescence;
rox ssdna;
activity inhibition ... See more keywords
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Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00075
Abstract: Coactivator-associated arginine methyltransferase 1 (CARM1) is a member of the family of protein arginine methyltransferases. CARM1 catalyzes methyl group transfer from the cofactor S-adenosyl-l-methionine (AdoMet) to both histone and nonhistone protein substrates. CARM1 is involved…
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Keywords:
activity inhibition;
coactivator associated;
arginine methyltransferase;
carm1 ... See more keywords
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Published in 2017 at "Nature chemical biology"
DOI: 10.1038/nchembio.2357
Abstract: O-GlcNAc hydrolase (OGA) catalyzes removal of βα-linked N-acetyl-D-glucosamine from serine and threonine residues. We report crystal structures of Homo sapiens OGA catalytic domain in apo and inhibited states, revealing a flexible dimer that displays three…
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Keywords:
crystal structure;
activity inhibition;
inhibition crystal;
structure human ... See more keywords
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Published in 2021 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkab513
Abstract: Abstract The rnlAB toxin-antitoxin operon from Escherichia coli functions as an anti-phage defense system. RnlA was identified as a member of the HEPN (Higher Eukaryotes and Prokaryotes Nucleotide-binding domain) superfamily of ribonucleases. The activity of…
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Keywords:
hepn;
required activity;
rnla;
canonical hepn ... See more keywords
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Published in 2023 at "Corrosion Reviews"
DOI: 10.1515/corrrev-2022-0025
Abstract: Abstract The amperometric biosensor was created using a flat sheet of the Cu-Zn-Al shape memory alloy, with a shiny surface and uniform thickness below 1 mm. The high biocompatibility and a large specific surface area…
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Keywords:
activity inhibition;
vitro biomedical;
enzyme activity;
biomedical corrosion ... See more keywords
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Published in 2021 at "Biomedicines"
DOI: 10.3390/biomedicines9040423
Abstract: We propose a simple label-free electrochemical biosensor for monitoring protein kinase activity and inhibition using a peptide-modified electrode. The biosensor employs cys-kemptide (CLRRASLG) as a substrate peptide which was immobilized on the surface of a…
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Keywords:
activity inhibition;
sensor;
activity;
protein kinase ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23031203
Abstract: The organic cation transporters OCT1-3 (SLC22A1-3) facilitate the transport of cationic endo- and xenobiotics and are important mediators of drug distribution and elimination. Their polyspecific nature makes OCTs highly susceptible to drug–drug interactions (DDIs). Currently,…
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Keywords:
activity inhibition;
transport;
activity;
impedance ... See more keywords
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Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24119275
Abstract: Carbonic anhydrases (CAs) are a metalloenzyme family that have important roles in cellular processes including pH homeostasis and have been implicated in multiple pathological conditions. Small molecule inhibitors have been developed to target carbonic anhydrases,…
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Keywords:
carbonic anhydrases;
effects phosphorylation;
activity inhibition;
phosphorylation ... See more keywords
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Published in 2022 at "Molecules"
DOI: 10.3390/molecules27228016
Abstract: Anthocyanins are an important pharmaceutical ingredient possessing diet regulatory, antioxidant, anticancer, antidiabetic, anti-obesity, antimicrobial, and anti-inflammatory properties. Pelargonidin is an important anthocyanin-based orange-red flavonoid compound used in drugs for treating hypoglycemia, retinopathy, skeletal myopathy, etc.…
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Keywords:
efficiency pelargonidin;
activity inhibition;
structural activity;
pelargonidin ... See more keywords
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Published in 2022 at "Bioanalysis"
DOI: 10.4155/bio-2022-0004
Abstract: Background: Inhibition of the enzyme dipeptidyl peptidase 4 (DPP-4) is a pharmaceutical treatment for type 2 diabetes. To demonstrate bioequivalence of enzyme inhibition of a new dosage form of the inhibitor vildagliptin, a method for…
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Keywords:
inhibition dpp;
activity inhibition;
inhibition;
method ... See more keywords