Cortical and raphe GABAA, AMPA receptors and glial GLT-1 glutamate transporter contribute to the sustained antidepressant activity of ketamine
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DOI: 10.1016/j.pbb.2020.172913
Abstract: At sub-anaesthetic doses, ketamine, a non competitive N-methyl-d-aspartate (NMDA) receptor antagonist, has demonstrated remarkable and rapid antidepressant (AD) efficacy in patients with treatment-resistant depression (TRD). However, its mechanism of action of ketamine is not fully… read more here.
Keywords: like activity; mpfc; activity ketamine; sustained antidepressant ... See more keywords