Anticryptococcal activity and mechanistic studies of short amphipathic peptides
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DOI: 10.1002/ardp.202200576
Abstract: Cryptococcus neoformans, an opportunistic fungal pathogen, causes cryptococcosis in immunocompromised persons. A series of modified L‐histidines‐containing peptides are synthesized that exhibit promising activity against C. neoformans. Analog 11d [L‐His(2‐adamantyl)‐L‐Trp‐L‐His(2‐phenyl)‐OMe] produced potency with an IC50 of… read more here.
Keywords: short amphipathic; studies short; activity mechanistic; anticryptococcal activity ... See more keywords