Glucocerebrosidase Activity Modulates Neuronal Susceptibility to Pathological α-Synuclein Insult
Sign Up to like & getrecommendations! Published in 2020 at "Neuron"
DOI: 10.1016/j.neuron.2019.12.004
Abstract: Mutations in the GBA1 gene are the most common genetic risk factor for Parkinson's disease (PD) and dementia with Lewy bodies (DLB). GBA1 encodes the lysosomal lipid hydrolase glucocerebrosidase (GCase), and its activity has been… read more here.
Keywords: synuclein; activity modulates; activity; neuronal susceptibility ... See more keywords
Locomotor activity modulates associative learning in mouse cerebellum
Sign Up to like & getrecommendations! Published in 2018 at "Nature neuroscience"
DOI: 10.1038/s41593-018-0129-x
Abstract: Changes in behavioral state can profoundly influence brain function. Here we show that behavioral state modulates performance in delay eyeblink conditioning, a cerebellum-dependent form of associative learning. Increased locomotor speed in head-fixed mice drove earlier… read more here.
Keywords: locomotor; activity modulates; locomotor activity; cerebellum ... See more keywords
Proteasome activity modulates amyloid toxicity.
Sign Up to like & getrecommendations! Published in 2022 at "FEMS yeast research"
DOI: 10.1093/femsyr/foac004
Abstract: Alzheimer's Disease (AD) is responsible for 60-80% of identified cases of dementia. While the generation and accumulation of amyloid precursor protein (APP) fragments is accepted as a key step in AD pathogenesis, the precise role… read more here.
Keywords: modulates amyloid; proteasome; activity modulates; activity ... See more keywords