Leptin-Activity Modulators and Their Potential Pharmaceutical Applications
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DOI: 10.3390/biom11071045
Abstract: Leptin, a multifunctional hormone primarily, but not exclusively, secreted in adipose tissue, is implicated in a wide range of biological functions that control different processes, such as the regulation of body weight and energy expenditure,… read more here.
Keywords: leptin; leptin receptor; activity modulators; leptin activity ... See more keywords
Efficacy of Serotonin and Dopamine Activity Modulators in the Treatment of Negative Symptoms in Schizophrenia: A Rapid Review
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DOI: 10.3390/biomedicines11030921
Abstract: Schizophrenia is among the fifteen most disabling diseases worldwide. Negative symptoms (NS) are highly prevalent in schizophrenia, negatively affect the functional outcome of the disorder, and their treatment is difficult and rarely specifically investigated. Serotonin-dopamine… read more here.
Keywords: rapid review; negative symptoms; serotonin dopamine; dopamine activity ... See more keywords
Virtual Screening in the Identification of Sirtuins’ Activity Modulators
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DOI: 10.3390/molecules27175641
Abstract: Sirtuins are NAD+-dependent deac(et)ylases with different subcellular localization. The sirtuins’ family is composed of seven members, named SIRT-1 to SIRT-7. Their substrates include histones and also an increasing number of different proteins. Sirtuins regulate a… read more here.
Keywords: virtual screening; sirtuins activity; sirtuins modulators; activity modulators ... See more keywords