Articles with "activity molecular" as a keyword



Photo by robbie36 from unsplash

Synthesis, anticholinesterase activity, molecular docking, and molecular dynamic simulation studies of 1,3,4‐oxadiazole derivatives

Sign Up to like & get
recommendations!
Published in 2022 at "Archiv der Pharmazie"

DOI: 10.1002/ardp.202200294

Abstract: Two new series of 1,3,4‐oxadiazoles bearing pyridine and thiazole heterocycles (4a‐h and 5a‐h) were synthesized (2,5‐disubstituted‐1,3,4‐oxadiazoles). The structures of these newly synthesized compounds were confirmed by 1H nuclear magnetic resonance (NMR), 13C NMR, high‐resolution mass… read more here.

Keywords: molecular docking; activity molecular; molecular dynamic; anticholinesterase activity ... See more keywords
Photo from wikipedia

Antioxidant activity and molecular docking study of Erythrina × neillii polyphenolics

Sign Up to like & get
recommendations!
Published in 2019 at "South African Journal of Botany"

DOI: 10.1016/j.sajb.2018.12.011

Abstract: Abstract Species of genus Erythrina have a great contribution in folk medicine; various species are utilized as a tranquilizer, to treat insomnia, inflammation and colic. Besides, Erythrina species have reported antioxidant, hepatoprotective and anxiolytic activities.… read more here.

Keywords: activity molecular; molecular docking; antioxidant activity; activity ... See more keywords
Photo by robbie36 from unsplash

Synthesis, Fungicidal Activity, and Molecular Docking of 2-Acylamino and 2-Thioacylamino Derivatives of 1H-benzo[d]imidazoles as Anti-Tubulin Agents.

Sign Up to like & get
recommendations!
Published in 2021 at "Journal of agricultural and food chemistry"

DOI: 10.1021/acs.jafc.1c03325

Abstract: This work deals with the synthesis and evaluation of fungicidal activity of benzimidazole derivatives, which are structural analogues of commercial anti-tubulin fungicides. A number of N-acyl and N-thioacyl derivatives of 2-amino-1H-benzo[d]imidazole were prepared, and their… read more here.

Keywords: anti tubulin; docking; fungicidal activity; activity molecular ... See more keywords
Photo by robbie36 from unsplash

Cytotoxic activity and molecular targets of atractylodin in cholangiocarcinoma cells

Sign Up to like & get
recommendations!
Published in 2019 at "Journal of Pharmacy and Pharmacology"

DOI: 10.1111/jphp.13024

Abstract: To evaluate the cytotoxic activity of atractylodin and its potential effects on heme oxygenase (HO)‐1 production, STAT1/3 phosporylation and major NF‐κB protein expression in the cholangiocarcinoma‐associated cell line CL‐6. read more here.

Keywords: cholangiocarcinoma; activity molecular; targets atractylodin; activity ... See more keywords
Photo by robbie36 from unsplash

Synthesis, Biological Activity, and Molecular Docking Assessment of Some New Sulfonylated Tetrazole Derivatives

Sign Up to like & get
recommendations!
Published in 2019 at "Russian Journal of General Chemistry"

DOI: 10.1134/s1070363219090202

Abstract: The designed molecular structures have been subjected to computational analysis for calculating their physicochemical properties and drug likeness. The calculated data indicate that most of the compound possess the bioactivity score in the active zone.… read more here.

Keywords: synthesis biological; biological activity; activity molecular; molecular docking ... See more keywords
Photo from wikipedia

Synthesis, antitumor activity, molecular docking and DFT study of Novel pyrimidiopyrazole derivatives.

Sign Up to like & get
recommendations!
Published in 2019 at "Current computer-aided drug design"

DOI: 10.2174/1573409915666190710094425

Abstract: In this investigation, the reaction of 2-cyano-N-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl) acetamide (3) with dimethylformamide dimethyl acetal (DMF-DMA) to afford the corresponding (E)-2-cyano-3-(dimethylamino)-N-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylamide (4) utilizing microwave irradiation. The condensation reactions of (E)-2-cyano-3-(dimethylamino)-N-(2,4-dioxo-1,2,3,4-tetrahydro pyrimidin-5-yl) acrylamide (4) with hydrazine derivatives to… read more here.

Keywords: synthesis antitumor; activity molecular; molecular docking; antitumor activity ... See more keywords
Photo from wikipedia

Synthesis, Tyrosinase Inhibiting Activity and Molecular Docking of Fluorinated Pyrazole Aldehydes as Phosphodiesterase Inhibitors

Sign Up to like & get
recommendations!
Published in 2019 at "Applied Sciences"

DOI: 10.3390/app9081704

Abstract: A series of fluorinated 4,5-dihydro-1H-pyrazole derivatives were synthesized in the reaction of corresponding acetophenone and different aldehydes followed by the second step synthesis of desired compounds from synthesized chalcone, hydrazine hydrate, and formic acid. Structures… read more here.

Keywords: synthesis tyrosinase; activity molecular; tyrosinase inhibiting; molecular docking ... See more keywords
Photo from wikipedia

Synthesis, Biological Activity and Molecular Docking of Chimeric Peptides Targeting Opioid and NOP Receptors

Sign Up to like & get
recommendations!
Published in 2022 at "International Journal of Molecular Sciences"

DOI: 10.3390/ijms232012700

Abstract: Recently, mixed opioid/NOP agonists came to the spotlight for their favorable functional profiles and promising outcomes in clinical trials as novel analgesics. This study reports on two novel chimeric peptides incorporating the fragment Tyr-c[D-Lys-Phe-Phe]Asp-NH2 (RP-170),… read more here.

Keywords: synthesis biological; opioid nop; activity molecular; biological activity ... See more keywords