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Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200294
Abstract: Two new series of 1,3,4‐oxadiazoles bearing pyridine and thiazole heterocycles (4a‐h and 5a‐h) were synthesized (2,5‐disubstituted‐1,3,4‐oxadiazoles). The structures of these newly synthesized compounds were confirmed by 1H nuclear magnetic resonance (NMR), 13C NMR, high‐resolution mass…
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Keywords:
molecular docking;
activity molecular;
molecular dynamic;
anticholinesterase activity ... See more keywords
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Published in 2019 at "South African Journal of Botany"
DOI: 10.1016/j.sajb.2018.12.011
Abstract: Abstract Species of genus Erythrina have a great contribution in folk medicine; various species are utilized as a tranquilizer, to treat insomnia, inflammation and colic. Besides, Erythrina species have reported antioxidant, hepatoprotective and anxiolytic activities.…
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Keywords:
activity molecular;
molecular docking;
antioxidant activity;
activity ... See more keywords
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Published in 2021 at "Journal of agricultural and food chemistry"
DOI: 10.1021/acs.jafc.1c03325
Abstract: This work deals with the synthesis and evaluation of fungicidal activity of benzimidazole derivatives, which are structural analogues of commercial anti-tubulin fungicides. A number of N-acyl and N-thioacyl derivatives of 2-amino-1H-benzo[d]imidazole were prepared, and their…
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Keywords:
anti tubulin;
docking;
fungicidal activity;
activity molecular ... See more keywords
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Published in 2019 at "Journal of Pharmacy and Pharmacology"
DOI: 10.1111/jphp.13024
Abstract: To evaluate the cytotoxic activity of atractylodin and its potential effects on heme oxygenase (HO)‐1 production, STAT1/3 phosporylation and major NF‐κB protein expression in the cholangiocarcinoma‐associated cell line CL‐6.
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Keywords:
cholangiocarcinoma;
activity molecular;
targets atractylodin;
activity ... See more keywords
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Published in 2019 at "Russian Journal of General Chemistry"
DOI: 10.1134/s1070363219090202
Abstract: The designed molecular structures have been subjected to computational analysis for calculating their physicochemical properties and drug likeness. The calculated data indicate that most of the compound possess the bioactivity score in the active zone.…
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Keywords:
synthesis biological;
biological activity;
activity molecular;
molecular docking ... See more keywords
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Published in 2019 at "Current computer-aided drug design"
DOI: 10.2174/1573409915666190710094425
Abstract: In this investigation, the reaction of 2-cyano-N-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl) acetamide (3) with dimethylformamide dimethyl acetal (DMF-DMA) to afford the corresponding (E)-2-cyano-3-(dimethylamino)-N-(2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)acrylamide (4) utilizing microwave irradiation. The condensation reactions of (E)-2-cyano-3-(dimethylamino)-N-(2,4-dioxo-1,2,3,4-tetrahydro pyrimidin-5-yl) acrylamide (4) with hydrazine derivatives to…
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Keywords:
synthesis antitumor;
activity molecular;
molecular docking;
antitumor activity ... See more keywords
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Published in 2019 at "Applied Sciences"
DOI: 10.3390/app9081704
Abstract: A series of fluorinated 4,5-dihydro-1H-pyrazole derivatives were synthesized in the reaction of corresponding acetophenone and different aldehydes followed by the second step synthesis of desired compounds from synthesized chalcone, hydrazine hydrate, and formic acid. Structures…
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Keywords:
synthesis tyrosinase;
activity molecular;
tyrosinase inhibiting;
molecular docking ... See more keywords
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Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232012700
Abstract: Recently, mixed opioid/NOP agonists came to the spotlight for their favorable functional profiles and promising outcomes in clinical trials as novel analgesics. This study reports on two novel chimeric peptides incorporating the fragment Tyr-c[D-Lys-Phe-Phe]Asp-NH2 (RP-170),…
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Keywords:
synthesis biological;
opioid nop;
activity molecular;
biological activity ... See more keywords