Synthesis and antiproliferative activity of monocationic arylthiophene derivatives.
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DOI: 10.1016/j.ejmech.2016.12.007
Abstract: Eleven compounds of substituted 4-(5-arylthiophen-2-yl)benzamidines 4a-k were synthesized from their corresponding mononitriles via treatment with lithium trimethylsilylamide and subsequent de-protection with ethanol/hydrogen chloride. In vitro antiproliferative activities of the new monocationic arylthiophenes were evaluated against 60… read more here.
Keywords: tested monocations; cell lines; activity monocationic; synthesis antiproliferative ... See more keywords