Synthesis and photodynamic activity of new 5‐[(E)‐2‐(3‐alkoxy‐1‐phenyl‐1H‐pyrazol‐4‐yl)ethenyl]‐2‐phenyl‐3H‐indoles
Sign Up to like & getrecommendations! Published in 2024 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202400282
Abstract: A series of new indole‐pyrazole hybrids 8a–m were synthesized through the palladium‐catalyzed ligandless Heck coupling reaction from easily accessible unsubstituted, methoxy‐ or fluoro‐substituted 4‐ethenyl‐1H‐pyrazoles and 5‐bromo‐3H‐indoles. These compounds exerted cytotoxicity to melanoma G361 cells when… read more here.
Keywords: new alkoxy; photodynamic activity; phenyl; alkoxy phenyl ... See more keywords
Synthesis and Antimicrobial Activity of Some New 3,4‐Disubstituted Pyrroles and Pyrazoles
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DOI: 10.1002/jhet.3012
Abstract: A variety of 3,4-disubstituted pyrroles and pyrazoles were synthesized by the treatment of 1,3-dipolar reagents viz., tosylmethyl isocyanide, and diazomethane to heteroaryl chalcones and evaluated for their antimicrobial activity. Among all the tested compounds, 14b… read more here.
Keywords: activity new; disubstituted pyrroles; antimicrobial activity; synthesis antimicrobial ... See more keywords
Fidelity of global tropical cyclone activity in a new reanalysis dataset (CRA40)
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DOI: 10.1002/met.70009
Abstract: This study systematically evaluated global tropical cyclone (TC) activity in a new global atmospheric reanalysis dataset named the “40‐year Global Reanalysis” (CRA40) against the best track data. For comparison, four state‐of‐the‐art reanalyses—ERA5, JRA55, CFSR, and… read more here.
Keywords: global tropical; tropical cyclone; cyclone activity; reanalysis ... See more keywords
Synthesis and antioxidant activity of some new N-alkylated pyrazole-containing benzimidazoles
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DOI: 10.1007/s10593-017-2036-6
Abstract: A series of new N-substituted pyrazole-containing benzimidazoles was synthesized starting from 1,2-diaminobenzene and pyrazole-4-carbaldehyde in good yield. Antioxidant activity of all title compounds was assessed using 2,2-diphenyl-1-picrylhydrazyl and hydrogen peroxide assays. Some of the synthesized… read more here.
Keywords: antioxidant activity; activity new; containing benzimidazoles; synthesis antioxidant ... See more keywords
Synthesis, characterization, and antileukemic activity of new water-soluble analogs of prodimin
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DOI: 10.1007/s11172-019-2435-1
Abstract: Two new compounds from the class of bis(3-halopropionyl)amides were synthesized by the reaction of 3-halopropionyl chloride with N,N′-dimethylethylenediamine. These structural analogs of prodimin, a water insoluble anticancer drug, are soluble in water, which significantly expands… read more here.
Keywords: analogs prodimin; antileukemic activity; activity new; water ... See more keywords
Synthesis and antiproliferative activity of new hybrids bearing neocryptolepine, acridine and α-aminophosphonate scaffolds
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-019-01849-2
Abstract: Synthesis of novel α-aminophosphonate hybrids 8a–f was accomplished by the reaction of 11-phenoxy-4-formylneocryptolepine 3 , aminoalkylamino acridines 6a–f and diphenyl phosphite 7 in the presence of lithium perchlorate as Lewis acid catalyst in methanol. The… read more here.
Keywords: activity new; synthesis antiproliferative; antiproliferative activity; cancer cell ... See more keywords
Synthesis and cytotoxic activity of new indolylpyrrole derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2021.103209
Abstract: Abstract The current approach described the synthesis of a new series of indolylpyrrole derivatives through multicomponent reaction of α-cyano chalcones, appropriate aldehydes, and ammonium acetate in refluxed acetic acid. The chemical structures of the designed… read more here.
Keywords: activity new; cytotoxic activity; activity; synthesis cytotoxic ... See more keywords
Synthesis and antiproliferative activity of new 2-glyco-3-nitro-2H-chromenes.
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DOI: 10.1016/j.bioorg.2019.03.016
Abstract: 3-nitro-2H-chromenes and derivatives are compounds with diverse biological activity, among them, new 2-glyco-3-nitro-2H-chromenes have been prepared by one-pot oxa-Michael-Henry-dehydration reactions between carbohydrate-derived nitroalkenes and several salicylaldehydes, using a minimal amount of solvent and DBU as… read more here.
Keywords: new glyco; activity new; glyco nitro; nitro chromenes ... See more keywords
Anticancer, antibacterial and antifungal activity of new ni (ii) and cu (ii) complexes of imidazole-phenanthroline derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Nucleosides, Nucleotides and Nucleic Acids"
DOI: 10.1080/15257770.2017.1388393
Abstract: ABSTRACT Two new nickel(II) and copper(II) complexes of 2-(Furan-2-yl)-1H-Imidazo[4,5-f][1,10]Phenanthroline (FIP) and 2-(thiophen-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline (TIP), imidazophen derivatives were synthesized. The structures of the compounds were determined by UV-visible and FT-IR spectroscopic methods and elemental analysis. The biological… read more here.
Keywords: antibacterial antifungal; activity new; anticancer antibacterial; phenanthroline ... See more keywords
Synthesis and Antimicrobial Activity of Some New Isatins Containing Benzotriazole Fragment
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DOI: 10.1134/s1070363218080303
Abstract: New isatin derivatives bearing benzotriazole substituent at the endocyclic nitrogen atom were synthesized. The resulting compounds and trimethylammonium acylhydrazones on their basis show a pronounced antimicrobial activity. read more here.
Keywords: isatins containing; activity new; new isatins; antimicrobial activity ... See more keywords
Synthesis and Antimicrobial Activity of New Heteroaryl(aryl) Thiazole Derivatives Molecular Docking Studies
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DOI: 10.3390/antibiotics11101337
Abstract: Herein, we report the design, synthesis, and evaluation of the antimicrobial activity of new heteroaryl (aryl) thiazole derivatives. The design was based on a molecular hybridization approach. The in vitro evaluation revealed that these compounds… read more here.
Keywords: antimicrobial activity; aryl thiazole; new heteroaryl; heteroaryl aryl ... See more keywords