Synthesis and Antimicrobial Activity of Some New 3,4‐Disubstituted Pyrroles and Pyrazoles
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DOI: 10.1002/jhet.3012
Abstract: A variety of 3,4-disubstituted pyrroles and pyrazoles were synthesized by the treatment of 1,3-dipolar reagents viz., tosylmethyl isocyanide, and diazomethane to heteroaryl chalcones and evaluated for their antimicrobial activity. Among all the tested compounds, 14b… read more here.
Keywords: activity new; disubstituted pyrroles; antimicrobial activity; synthesis antimicrobial ... See more keywords
Synthesis and antioxidant activity of some new N-alkylated pyrazole-containing benzimidazoles
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DOI: 10.1007/s10593-017-2036-6
Abstract: A series of new N-substituted pyrazole-containing benzimidazoles was synthesized starting from 1,2-diaminobenzene and pyrazole-4-carbaldehyde in good yield. Antioxidant activity of all title compounds was assessed using 2,2-diphenyl-1-picrylhydrazyl and hydrogen peroxide assays. Some of the synthesized… read more here.
Keywords: antioxidant activity; activity new; containing benzimidazoles; synthesis antioxidant ... See more keywords
Synthesis, characterization, and antileukemic activity of new water-soluble analogs of prodimin
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DOI: 10.1007/s11172-019-2435-1
Abstract: Two new compounds from the class of bis(3-halopropionyl)amides were synthesized by the reaction of 3-halopropionyl chloride with N,N′-dimethylethylenediamine. These structural analogs of prodimin, a water insoluble anticancer drug, are soluble in water, which significantly expands… read more here.
Keywords: analogs prodimin; antileukemic activity; activity new; water ... See more keywords
Synthesis and antiproliferative activity of new hybrids bearing neocryptolepine, acridine and α-aminophosphonate scaffolds
Sign Up to like & getrecommendations! Published in 2020 at "Journal of the Iranian Chemical Society"
DOI: 10.1007/s13738-019-01849-2
Abstract: Synthesis of novel α-aminophosphonate hybrids 8a–f was accomplished by the reaction of 11-phenoxy-4-formylneocryptolepine 3 , aminoalkylamino acridines 6a–f and diphenyl phosphite 7 in the presence of lithium perchlorate as Lewis acid catalyst in methanol. The… read more here.
Keywords: activity new; synthesis antiproliferative; antiproliferative activity; cancer cell ... See more keywords
Synthesis and cytotoxic activity of new indolylpyrrole derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2021.103209
Abstract: Abstract The current approach described the synthesis of a new series of indolylpyrrole derivatives through multicomponent reaction of α-cyano chalcones, appropriate aldehydes, and ammonium acetate in refluxed acetic acid. The chemical structures of the designed… read more here.
Keywords: activity new; cytotoxic activity; activity; synthesis cytotoxic ... See more keywords
Synthesis and antiproliferative activity of new 2-glyco-3-nitro-2H-chromenes.
Sign Up to like & getrecommendations! Published in 2019 at "Bioorganic chemistry"
DOI: 10.1016/j.bioorg.2019.03.016
Abstract: 3-nitro-2H-chromenes and derivatives are compounds with diverse biological activity, among them, new 2-glyco-3-nitro-2H-chromenes have been prepared by one-pot oxa-Michael-Henry-dehydration reactions between carbohydrate-derived nitroalkenes and several salicylaldehydes, using a minimal amount of solvent and DBU as… read more here.
Keywords: new glyco; activity new; glyco nitro; nitro chromenes ... See more keywords
Anticancer, antibacterial and antifungal activity of new ni (ii) and cu (ii) complexes of imidazole-phenanthroline derivatives
Sign Up to like & getrecommendations! Published in 2017 at "Nucleosides, Nucleotides and Nucleic Acids"
DOI: 10.1080/15257770.2017.1388393
Abstract: ABSTRACT Two new nickel(II) and copper(II) complexes of 2-(Furan-2-yl)-1H-Imidazo[4,5-f][1,10]Phenanthroline (FIP) and 2-(thiophen-2-yl)-1H-imidazo[4,5-f][1,10]phenanthroline (TIP), imidazophen derivatives were synthesized. The structures of the compounds were determined by UV-visible and FT-IR spectroscopic methods and elemental analysis. The biological… read more here.
Keywords: antibacterial antifungal; activity new; anticancer antibacterial; phenanthroline ... See more keywords
Synthesis and Antimicrobial Activity of Some New Isatins Containing Benzotriazole Fragment
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DOI: 10.1134/s1070363218080303
Abstract: New isatin derivatives bearing benzotriazole substituent at the endocyclic nitrogen atom were synthesized. The resulting compounds and trimethylammonium acylhydrazones on their basis show a pronounced antimicrobial activity. read more here.
Keywords: isatins containing; activity new; new isatins; antimicrobial activity ... See more keywords
Synthesis and Antimicrobial Activity of New Heteroaryl(aryl) Thiazole Derivatives Molecular Docking Studies
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DOI: 10.3390/antibiotics11101337
Abstract: Herein, we report the design, synthesis, and evaluation of the antimicrobial activity of new heteroaryl (aryl) thiazole derivatives. The design was based on a molecular hybridization approach. The in vitro evaluation revealed that these compounds… read more here.
Keywords: antimicrobial activity; aryl thiazole; new heteroaryl; heteroaryl aryl ... See more keywords
Varnishes with Biocidal Activity: A New Approach to Protecting Artworks
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DOI: 10.3390/app10207319
Abstract: Keeping agents that cause biodeterioration under control is a common task in restoring and conserving artworks. However, there are very few studies, specifically those concentrating on pictorial works, that provide solutions compatible with the complex… read more here.
Keywords: activity new; biocidal activity; new approach; protecting artworks ... See more keywords
Monitoring Nrf2/ARE Pathway Activity with a New Zebrafish Reporter System
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24076804
Abstract: Among multiple cytoprotective mechanisms, eukaryotic cells exhibit a complex transcriptional program relying on the Nrf2 transcription factor, which is generally recruited upon biological stressors including oxidative-stress-based cellular insults. The relevance of this master regulator has… read more here.
Keywords: monitoring nrf2; pathway activity; nrf2 pathway; activity new ... See more keywords