Enantioseparation and antioxidant activity of novel diarylpyrazoline derivatives.
Sign Up to like & getrecommendations! Published in 2022 at "Chirality"
DOI: 10.1002/chir.23493
Abstract: Three chiral pyrazoline derivatives were synthesized by a flavanone ring-opening reaction followed by cyclocondensation with hydrazine hydrate to give better yields. Their enantiomeric resolution was achieved using polysaccharide chiral stationary phase columns consisting of cellulose… read more here.
Keywords: antioxidant activity; activity novel; activity; enantioseparation antioxidant ... See more keywords
Synthesis and Antimicrobial Activity of Some Novel Quinoline, Chromene, Pyrazole Derivatives Bearing Triazolopyrimidine Moiety
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2645
Abstract: 7-Amino-3-phenyl-[1,2,4]triazolo [4,3-a] pyrimidin-5(1H)-one () was utilized as key intermediate for the synthesis of some new, quinolines and , acrylonitrile and , coumarin , and pyrazoles incorporating triazolopyrimidines. The structures of the newly synthesized compounds were… read more here.
Keywords: activity novel; antimicrobial activity; novel quinoline; quinoline chromene ... See more keywords
SYNTHESIS AND ANTIVIRAL ACTIVITY OF NOVEL 3-SUBSTITUTED PYRAZOLINIUM SALTS
Sign Up to like & getrecommendations! Published in 2021 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/6071
Abstract: For the first time, convenient methods for the preparation of pyrazoline N-alkylidene salts based on terpene (camphor, camphorquinone, carvone) ketones, cage (adamantanone and norcamphor) ketones, and natural aldehydes (carvone and myrtenal) allowing the isolation of… read more here.
Keywords: activity novel; antiviral activity; pyrazolinium salts; activity ... See more keywords
Synthesis and neuroprotective activity of novel 1,2,4-triazine derivatives with ethyl acetate moiety against H2O2 and Aβ-induced neurotoxicity
Sign Up to like & getrecommendations! Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2003-x
Abstract: A series of 5,6-diaryl-1,2,4-triazine-3-thioacetate derivatives 3a–f, 8a–d and their regioisomer 8e were synthesized. Neuroprotective activity of compounds was assessed against H2O2 and β-amyloid-induced toxicity in PC12 and SH-SY5Y cells respectively. Surprisingly, ethyl 2-(5-(4-chlorophenyl)-6-(4-methoxyphenyl)-3-thioxo-1,2,4-triazin-2(3H)-yl)acetate (8e) was… read more here.
Keywords: activity novel; synthesis neuroprotective; h2o2 induced; neuroprotective activity ... See more keywords
Synthesis and anticholinesterase activity of novel non-hepatotoxic naphthyridine-11-amine derivatives.
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Diversity"
DOI: 10.1007/s11030-018-9897-1
Abstract: In the present study, 14 novel naphthyridine-11-amine derivatives were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 12-(4-Fluorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1, 8]naphthyridin-11-amine (4a) was found to be the most potent AChE inhibitor with… read more here.
Keywords: amine; amine derivatives; synthesis anticholinesterase; anticholinesterase activity ... See more keywords
Antibacterial Activity of Novel 18β-Glycyrrhetinic Hydrazide or Amide Derivatives
Sign Up to like & getrecommendations! Published in 2021 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-021-0370-9
Abstract: Through a facile structural modification on the natural bioactive ingredient 18β-glycyrrhetinic acid(GA), a series of novel GA hydrazide or amide derivatives was obtained, and their final molecular frameworks were characterized by NMR and HRMS analysis.… read more here.
Keywords: amide derivatives; antibacterial activity; hydrazide amide; activity novel ... See more keywords
Synthesis and antibacterial activity of novel N-acylsulfonamides
Sign Up to like & getrecommendations! Published in 2017 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2013.01.016
Abstract: Abstract A series of novel N -acylsulfonamide derivatives were synthesized and characterized by 1 H NMR, 13 C NMR and HRMS. The N -acylsulfonamides were prepared in four steps (carbamoylation, sulfamoylation, deprotection and acylation) starting… read more here.
Keywords: novel; synthesis antibacterial; novel acylsulfonamides; activity novel ... See more keywords
A valuable peroxidase activity from the novel species Nonomuraea gerenzanensis growing on alkali lignin
Sign Up to like & getrecommendations! Published in 2017 at "Biotechnology Reports"
DOI: 10.1016/j.btre.2016.12.005
Abstract: Graphical abstract Treatment of 50 μM RBBR with 60 μg of N. gerenzanensis peroxidase preparation: the dye decolorizing activity was clearly observed. read more here.
Keywords: valuable peroxidase; peroxidase; gerenzanensis; activity novel ... See more keywords
Synthesis and anticancer activity of novel water soluble benzimidazole carbamates.
Sign Up to like & getrecommendations! Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.11.037
Abstract: Metastases account for more than 90% of all cancer deaths and respond poorly to most therapies. There remains an urgent need for new therapeutic modalities for the treatment of advanced metastatic cancers. The benzimidazole methylcarbamate… read more here.
Keywords: activity novel; water; anticancer activity; cancer ... See more keywords
Antitumor activity of novel POLA1-HDAC11 dual inhibitors.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113971
Abstract: Hybrid molecules targeting simultaneously DNA polymerase α (POLA1) and histone deacetylases (HDACs) were designed and synthesized to exploit a potential synergy of action. Among a library of screened molecules, MIR002 and GEM144 showed antiproliferative activity… read more here.
Keywords: activity novel; novel pola1; mir002 gem144; antitumor activity ... See more keywords
Synthesis, structures and biological activity of novel complexes with trifluorinated anthranilic acid derivatives
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.05.062
Abstract: Abstract Two cobalt complexes [Co2(L)(phen)(Ac)(PLC)] (1), [Co3(HL)4(CH3O)2(H2O)2] (2) and one zinc complex [Zn2(L)(phen)(Ac)(PLC)] (3), (L = (2-carboxylato-5-(trifluoromethyl)phenyl) (3-hydroxy-4-methoxyphenoxy)amide, phen = 1,10-phenanthroline, Ac = acetate, PLC = 2-amino-4-trifluoromethylbenzoate) have been synthesized and characterized by physicochemical and spectroscopic methods. In addition, X-ray crystallography shows… read more here.
Keywords: biological activity; activity; novel complexes; synthesis structures ... See more keywords