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Published in 2022 at "Chirality"
DOI: 10.1002/chir.23493
Abstract: Three chiral pyrazoline derivatives were synthesized by a flavanone ring-opening reaction followed by cyclocondensation with hydrazine hydrate to give better yields. Their enantiomeric resolution was achieved using polysaccharide chiral stationary phase columns consisting of cellulose…
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Keywords:
antioxidant activity;
activity novel;
activity;
enantioseparation antioxidant ... See more keywords
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Published in 2017 at "Journal of Heterocyclic Chemistry"
DOI: 10.1002/jhet.2645
Abstract: 7-Amino-3-phenyl-[1,2,4]triazolo [4,3-a] pyrimidin-5(1H)-one () was utilized as key intermediate for the synthesis of some new, quinolines and , acrylonitrile and , coumarin , and pyrazoles incorporating triazolopyrimidines. The structures of the newly synthesized compounds were…
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Keywords:
activity novel;
antimicrobial activity;
novel quinoline;
quinoline chromene ... See more keywords
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Published in 2021 at "Chemistry of Heterocyclic Compounds"
DOI: 10.1007/6071
Abstract: For the first time, convenient methods for the preparation of pyrazoline N-alkylidene salts based on terpene (camphor, camphorquinone, carvone) ketones, cage (adamantanone and norcamphor) ketones, and natural aldehydes (carvone and myrtenal) allowing the isolation of…
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Keywords:
activity novel;
antiviral activity;
pyrazolinium salts;
activity ... See more keywords
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Published in 2017 at "Medicinal Chemistry Research"
DOI: 10.1007/s00044-017-2003-x
Abstract: A series of 5,6-diaryl-1,2,4-triazine-3-thioacetate derivatives 3a–f, 8a–d and their regioisomer 8e were synthesized. Neuroprotective activity of compounds was assessed against H2O2 and β-amyloid-induced toxicity in PC12 and SH-SY5Y cells respectively. Surprisingly, ethyl 2-(5-(4-chlorophenyl)-6-(4-methoxyphenyl)-3-thioxo-1,2,4-triazin-2(3H)-yl)acetate (8e) was…
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Keywords:
activity novel;
synthesis neuroprotective;
h2o2 induced;
neuroprotective activity ... See more keywords
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Published in 2019 at "Molecular Diversity"
DOI: 10.1007/s11030-018-9897-1
Abstract: In the present study, 14 novel naphthyridine-11-amine derivatives were synthesized and their inhibitory effects on acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) were evaluated. 12-(4-Fluorophenyl)-1,2,3,4,7,8,9,10-octahydrodibenzo[b,g][1, 8]naphthyridin-11-amine (4a) was found to be the most potent AChE inhibitor with…
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Keywords:
amine;
amine derivatives;
synthesis anticholinesterase;
anticholinesterase activity ... See more keywords
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Published in 2021 at "Chemical Research in Chinese Universities"
DOI: 10.1007/s40242-021-0370-9
Abstract: Through a facile structural modification on the natural bioactive ingredient 18β-glycyrrhetinic acid(GA), a series of novel GA hydrazide or amide derivatives was obtained, and their final molecular frameworks were characterized by NMR and HRMS analysis.…
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Keywords:
amide derivatives;
antibacterial activity;
hydrazide amide;
activity novel ... See more keywords
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Published in 2017 at "Arabian Journal of Chemistry"
DOI: 10.1016/j.arabjc.2013.01.016
Abstract: Abstract A series of novel N -acylsulfonamide derivatives were synthesized and characterized by 1 H NMR, 13 C NMR and HRMS. The N -acylsulfonamides were prepared in four steps (carbamoylation, sulfamoylation, deprotection and acylation) starting…
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Keywords:
novel;
synthesis antibacterial;
novel acylsulfonamides;
activity novel ... See more keywords
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Published in 2017 at "Biotechnology Reports"
DOI: 10.1016/j.btre.2016.12.005
Abstract: Graphical abstract Treatment of 50 μM RBBR with 60 μg of N. gerenzanensis peroxidase preparation: the dye decolorizing activity was clearly observed.
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Keywords:
valuable peroxidase;
peroxidase;
gerenzanensis;
activity novel ... See more keywords
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Published in 2018 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2017.11.037
Abstract: Metastases account for more than 90% of all cancer deaths and respond poorly to most therapies. There remains an urgent need for new therapeutic modalities for the treatment of advanced metastatic cancers. The benzimidazole methylcarbamate…
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Keywords:
activity novel;
water;
anticancer activity;
cancer ... See more keywords
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Published in 2021 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2021.113971
Abstract: Hybrid molecules targeting simultaneously DNA polymerase α (POLA1) and histone deacetylases (HDACs) were designed and synthesized to exploit a potential synergy of action. Among a library of screened molecules, MIR002 and GEM144 showed antiproliferative activity…
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Keywords:
activity novel;
novel pola1;
mir002 gem144;
antitumor activity ... See more keywords
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Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.05.062
Abstract: Abstract Two cobalt complexes [Co2(L)(phen)(Ac)(PLC)] (1), [Co3(HL)4(CH3O)2(H2O)2] (2) and one zinc complex [Zn2(L)(phen)(Ac)(PLC)] (3), (L = (2-carboxylato-5-(trifluoromethyl)phenyl) (3-hydroxy-4-methoxyphenoxy)amide, phen = 1,10-phenanthroline, Ac = acetate, PLC = 2-amino-4-trifluoromethylbenzoate) have been synthesized and characterized by physicochemical and spectroscopic methods. In addition, X-ray crystallography shows…
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Keywords:
biological activity;
activity;
novel complexes;
synthesis structures ... See more keywords