Anti-PEG Antibodies Inhibit the Anticoagulant Activity of PEGylated Aptamers.
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DOI: 10.1016/j.chembiol.2019.02.001
Abstract: Biopharmaceuticals have become increasingly attractive therapeutic agents and are often PEGylated to enhance their pharmacokinetics and reduce their immunogenicity. However, recent human clinical trials have demonstrated that administration of PEGylated compounds can evoke anti-PEG antibodies.… read more here.
Keywords: peg antibodies; anti peg; inhibit anticoagulant; activity pegylated ... See more keywords