Advanced Strategies of Enzyme Activity Regulation for Biomedical Applications
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200358
Abstract: Enzymes are important macromolecular biocatalysts that accelerate chemical and biochemical reactions in living organisms. Most human diseases are related to alterations in enzyme activity. Moreover, enzymes are potential therapeutic tools for treating different diseases, such… read more here.
Keywords: biomedical applications; enzyme activity; activity; advanced strategies ... See more keywords
Activity Regulation of Fenton/Fenton‐like Reactions in Single‐Atom Catalysis
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DOI: 10.1002/cctc.202201579
Abstract: On the one hand, Fenton‐like reactions are common side reactions in electrocatalytic oxygen reduction reaction (ORR). The generated reactive oxygen species (ROS) could damage the active sites of single‐atom catalysts (SACs), thereby affecting the stability… read more here.
Keywords: fenton; regulation fenton; fenton like; single atom ... See more keywords
Structural basis for the activity and regulation of human α-ketoglutarate dehydrogenase revealed by Cryo-EM.
Sign Up to like & getrecommendations! Published in 2022 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2022.02.093
Abstract: The human mitochondrial alpha-ketoglutarate (α-KG) dehydrogenase complex (hKGDHc) is a well-studied macromolecular enzyme that converts α-KG to succinyl-CoA and NADH. Abnormalities of the complex lead to several diseases, including neurodegenerative disorders. Despite its importance in… read more here.
Keywords: regulation human; activity regulation; structural basis; dehydrogenase ... See more keywords
ALDH2---The Genetic Polymorphism and Enzymatic Activity Regulation: Their Epidemiologic and Clinical Implications.
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DOI: 10.2174/1389450116666150727115118
Abstract: BACKGROUND The human aldehyde dehydrogenase 2 (ALDH2) is the most effective enzyme in the detoxification of alcohol metabolite acetaldehyde. The ALDH2*2 mutation is caused by a single nucleotide substitution which results in a nearly inactive… read more here.
Keywords: epidemiologic clinical; enzyme; activity regulation; genetic polymorphism ... See more keywords