Exploring Structure–Activity Relationships with Three‐Dimensional Matched Molecular Pairs—A Review
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DOI: 10.1002/cmdc.201700628
Abstract: A matched molecular pair (MMP) consists of two small molecules that differ by a few atoms only. The minor structural difference between the molecules allows a detailed analysis of changes in properties. Three‐dimensional (3D) MMPs… read more here.
Keywords: three dimensional; activity relationships; structure activity; structure ... See more keywords
Auranofin and its Analogues Show Potent Antimicrobial Activity against Multidrug‐Resistant Pathogens: Structure–Activity Relationships
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DOI: 10.1002/cmdc.201800498
Abstract: Due to the so‐called “antibiotic resistance crisis” new antibacterial agents are urgently sought to treat multidrug‐resistant pathogens. A group of gold‐ or silver‐based complexes, of general formula [M(PEt3)X] (with M=Au or Ag, and X=Cl, Br… read more here.
Keywords: activity relationships; resistant pathogens; structure activity; multidrug resistant ... See more keywords
Structure–Activity Relationships of 1‐Benzoylazulenes at the OX1 and OX2 Orexin Receptors
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DOI: 10.1002/cmdc.201900074
Abstract: We previously demonstrated the potential of di‐ or trisubstituted azulenes as ligands (potentiators, weak agonists, and antagonists) of the orexin receptors. In this study we investigated 27 1‐benzoylazulene derivatives, uncovering seven potentiators of the orexin… read more here.
Keywords: orexin receptors; activity relationships; relationships benzoylazulenes; structure activity ... See more keywords
Structure‐Activity Relationships of Butyrophilin 3 Ligands
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DOI: 10.1002/cmdc.202000198
Abstract: Phosphoantigens (pAgs) are small phosphorus‐containing molecules that stimulate Vγ9Vδ2 T cells with sub‐nanomolar cellular potency. Recent work has revealed that these compounds work through binding to the transmembrane immunoglobulin butyrophilin 3A1 (BTN3A1) within its intracellular… read more here.
Keywords: activity relationships; relationships butyrophilin; structure activity; butyrophilin ligands ... See more keywords
Synthesis and Structure−Activity Relationships of Imidazopyridine/Pyrimidine‐ and Furopyridine‐Based Anti‐infective Agents against Trypanosomiases
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DOI: 10.1002/cmdc.202000616
Abstract: Neglected tropical diseases remain among the most critical public health concerns in Africa and South America. The drug treatments for these diseases are limited, which invariably leads to fatal cases. Hence, there is an urgent… read more here.
Keywords: activity relationships; imidazopyridine pyrimidine; activity; structure activity ... See more keywords
Structure‐Activity Relationships for 5′′ Modifications of 4,5‐Aminoglycoside Antibiotics
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DOI: 10.1002/cmdc.202200120
Abstract: Modification at the 5’’‐position of 4,5‐disubstituted aminoglycoside antibiotics (AGAs) to circumvent inactivation by aminoglycoside modifying enzymes (AMEs) is well known. Such modifications, however, unpredictably impact activity and affect target selectivity thereby hindering drug development. A… read more here.
Keywords: structure activity; activity; activity relationships; aminoglycoside antibiotics ... See more keywords
Rigidity‐Activity Relationships of bisQPC Scaffolds against Pathogenic Bacteria
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DOI: 10.1002/cmdc.202200224
Abstract: Biscationic quaternary phosphonium compounds (bisQPCs) represent a promising class of antimicrobials, displaying potent activity against both Gram‐negative and Gram‐positive bacteria. In this study, we explored the effects of structural rigidity on the antimicrobial activity of… read more here.
Keywords: rigidity; relationships bisqpc; activity; bisqpc scaffolds ... See more keywords
Structure-Activity Relationships of Flupirtine Analogues for the Liver Esterase-mediated Cleavage of the 4-Fluorobenzylamine Moiety and its possible Relevance to Liver Toxicity.
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DOI: 10.1002/cmdc.202300145
Abstract: Flupirtine and retigabine were essential drugs to combat pain and epilepsy. However, the Kv7 potassium channel openers are fraught with hepatotoxicity and tissue discoloration, respectively, limiting their therapeutic value. Both adverse events are likely due… read more here.
Keywords: structure activity; relationships flupirtine; liver esterase; flupirtine analogues ... See more keywords
Structure-activity relationships for inhibitors of Pseudomonas aeruginosa exoenzyme S ADP-ribosyltransferase activity.
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DOI: 10.1016/j.ejmech.2017.11.036
Abstract: During infection, the Gram-negative opportunistic pathogen Pseudomonas aeruginosa employs its type III secretion system to translocate the toxin exoenzyme S (ExoS) into the eukaryotic host cell cytoplasm. ExoS is an essential in vivo virulence factor that… read more here.
Keywords: exoenzyme; pseudomonas aeruginosa; activity relationships; structure activity ... See more keywords
Structure-activity relationships in fungal nucleobases transporters as dissected by the inhibitory effects of novel purine analogues.
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DOI: 10.1016/j.ejmech.2018.06.038
Abstract: We have previously rationally designed, synthesized and tested a number of 3-deazapurine analogues, which inhibit the ubiquitous fungal nucleobase transporter FcyB, through binding in its major substrate binding site, by specifically interacting with Asn163. Here,… read more here.
Keywords: activity relationships; novel purine; structure activity; activity ... See more keywords
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.
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DOI: 10.1016/j.ejmech.2018.06.063
Abstract: We discovered a series of azole antifungal compounds as effective antiprotozoal agents. They displayed promising inhibitory activities within the micromolar-submicromolar range against P. falciparum, L. donovani, and T. b. rhodesiense. Moreover, most of such compounds showed excellent nanomolar… read more here.
Keywords: activity relationships; antiprotozoal agents; structure activity; biological evaluation ... See more keywords