Design, Synthesis, Antiproliferative Activity and In Silico Studies of 2-Oxo-1,2-Dihydroquinolin Derivatives
Sign Up to like & getrecommendations! Published in 2025 at "Polycyclic Aromatic Compounds"
DOI: 10.1080/10406638.2025.2459212
Abstract: Abstract Quinolines have long been recognized as a versatile scaffold for the development of various bioactive compounds. In this context, a series of quinoline-based compounds were designed and synthesized using two key building block synthons:… read more here.
Keywords: activity silico; synthesis antiproliferative; silico studies; antiproliferative activity ... See more keywords
Synthesis, Antimicrobial Activity and in silico Studies on Eugenol Eters.
Sign Up to like & getrecommendations! Published in 2018 at "Acta chimica Slovenica"
DOI: 10.17344/acsi.2018.4380
Abstract: The results presented herein represent our continued study based on the modification of phenolic functionality in molecules originated from natural sources by acylation. A small focused library of nineteen eugenyl esters, with four of which… read more here.
Keywords: activity silico; silico studies; antimicrobial activity; studies eugenol ... See more keywords
In vitro Antileishmanial Activity and In Silico Molecular Modeling Studies of Novel Analogs of Dermaseptins S4 and B2.
Sign Up to like & getrecommendations! Published in 2024 at "Current pharmaceutical biotechnology"
DOI: 10.2174/0113892010296038240427050421
Abstract: BACKGROUND Leishmaniasis is responsible for approximately 65,000 annual deaths. Various Leishmania species are the predominant cause of visceral, cutaneous, or mucocutaneous leishmaniasis, affecting millions worldwide. The lack of a vaccine, emergence of resistance, and undesirable… read more here.
Keywords: molecular modeling; activity silico; vitro antileishmanial; antileishmanial activity ... See more keywords
Biological Activity and In Silico Study of 3-Modified Derivatives of Betulin and Betulinic Aldehyde
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20061372
Abstract: A series of 3-substituted derivatives of betulin and betulinic aldehyde were synthesized as promising anticancer agents. The newly triterpenes were tested against five human cancer cell lines like biphenotypic B myelomonocytic leukaemia (MV-4-11), adenocarcinoma (A549),… read more here.
Keywords: biological activity; betulin betulinic; activity silico; betulinic aldehyde ... See more keywords
In Silico Predicted Antifungal Peptides: In Vitro and In Vivo Anti-Candida Activity
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Fungi"
DOI: 10.3390/jof7060439
Abstract: It has been previously demonstrated that synthetic antibody-derived peptides could exert a significant activity in vitro, ex vivo, and/or in vivo against microorganisms and viruses, as well as immunomodulatory effects through the activation of immune… read more here.
Keywords: activity silico; vitro vivo; parent peptide; predicted antifungal ... See more keywords
Antifungal Activity and In Silico Studies on 2-Acylated Benzo- and Naphthohydroquinones
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DOI: 10.3390/molecules27093035
Abstract: The high rates of morbidity and mortality due to fungal infections are associated with a limited antifungal arsenal and the high toxicity of drugs. Therefore, the identification of novel drug targets is challenging due to… read more here.
Keywords: antifungal activity; silico studies; naphthohydroquinones antifungal; activity ... See more keywords
Synthesis, Microbiological Activity and In Silico Investigation for Some Synthesized Coumarin Derivatives
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DOI: 10.5562/cca3637
Abstract: Four 4-hydroxycoumarin derivatives were synthesized and the structure was confirmed by NMR spectroscopy and Mass spectrometry. Tested compounds have shown significant antimicrobial activity against Bacillus subtilis subsp. spizizenii, Bacillus cereus, Staphylococcus aureus, and Staphylococcus epidermidis,… read more here.
Keywords: activity silico; tested compounds; antimicrobial activity; synthesis microbiological ... See more keywords