Antitumor activity and structure-activity relationship of heparanase inhibitors: Recent advances.
Sign Up to like & getrecommendations! Published in 2020 at "European journal of medicinal chemistry"
DOI: 10.1016/j.ejmech.2020.112221
Abstract: Heparanase (HPSE)-directed tumor progression plays a crucial role in mediating tumor-host crosstalk and priming the tumor microenvironment, leading to tumor growth, metastasis and chemo-resistance. HPSE-mediated breakdown of structural heparan sulfate (HS) networks in the extracellular… read more here.
Keywords: hpse; antitumor activity; activity structure; structure activity ... See more keywords
The effect of oxaloacetic acid on tyrosinase activity and structure: Integration of inhibition kinetics with docking simulation.
Sign Up to like & getrecommendations! Published in 2017 at "International journal of biological macromolecules"
DOI: 10.1016/j.ijbiomac.2017.03.073
Abstract: Oxaloacetic acid (OA) is naturally found in organisms and well known as an intermediate of citric acid cycle producing ATP. We evaluated the effects of OA on tyrosinase activity and structure via integrating methods of… read more here.
Keywords: tyrosinase activity; activity structure; tyrosinase; acid ... See more keywords
Anticancer Activity-Structure Relationship of Quinolinone-Based Compounds: An Overview.
Sign Up to like & getrecommendations! Published in 2021 at "Anti-cancer agents in medicinal chemistry"
DOI: 10.2174/1871520621666210112114439
Abstract: BACKGROUND Heterocyclic compounds play an important role in the pharmaceutical and biological processes. Among all heterocycles, quinolinone/quinoline has one of the most unique structures in the discovery of these compounds. These derivatives have been prepared… read more here.
Keywords: chemistry; anticancer activity; quinolinone; activity structure ... See more keywords
A Novel Adenosine Kinase from Bombyx mori: Enzymatic Activity, Structure, and Biological Function
Sign Up to like & getrecommendations! Published in 2019 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms20153732
Abstract: Adenosine kinase (ADK) is the first enzyme in the adenosine remediation pathway that catalyzes adenosine phosphorylation into adenosine monophosphate, thus regulating adenosine homeostasis in cells. To obtain new insights into ADK from Bombyx mori (BmADK),… read more here.
Keywords: bombyx mori; adenosine kinase; activity structure; bmadk ... See more keywords
Synthesis, anticancer activity, structure-activity relationship and binding mode of interaction studies of substituted pentanoic acids.
Sign Up to like & getrecommendations! Published in 2019 at "Future medicinal chemistry"
DOI: 10.4155/fmc-2018-0361
Abstract: Aim: Simultaneous inhibition of MMP-2 and HDAC8 may be an effective strategy to target cancer. Methodology: In continuation of our earlier efforts, a series of substituted pentanoic acids (1-18) were synthesized and checked for their… read more here.
Keywords: synthesis anticancer; anticancer activity; pentanoic acids; activity structure ... See more keywords