Design, synthesis, antitumor activity and theoretical calculation of novel PI3Ka inhibitors.
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DOI: 10.1016/j.bioorg.2020.103737
Abstract: PI3Kα has been identified as an ideal target to treat with PIK3CA gene mutation disease, including drugs such as Alpelisib and Copanlisib. Five purine analogues and four thiazole analogues were designed and synthesized. Their enzymaticactivity… read more here.
Keywords: design synthesis; synthesis antitumor; activity theoretical; antitumor activity ... See more keywords