Biological activity and toxicity of plant nutraceuticals: an overview
Sign Up to like & getrecommendations! Published in 2021 at "Current opinion in food science"
DOI: 10.1016/j.cofs.2021.05.008
Abstract: Plant nutraceuticals have currently been receiving international attention due to their potentially health-promoting effects when consumed as part of a varied diet, including antioxidant, anti-inflammatory, and anti-proliferative properties. These beneficial effects have been attributed to… read more here.
Keywords: biological activity; nutraceuticals overview; activity toxicity; toxicity plant ... See more keywords
Polytrimethylenimines: Highly Potent Antibacterial Agents with Activity and Toxicity Modulated by the Polymer Molecular Weight
Sign Up to like & getrecommendations! Published in 2023 at "Biomacromolecules"
DOI: 10.1021/acs.biomac.3c00139
Abstract: Cationic polymers have been extensively investigated as a potential replacement for traditional antibiotics. Here, we examined the effect of molecular weight (MW) on the antimicrobial, cytotoxic, and hemolytic activity of linear polytrimethylenimine (L-PTMI). The results… read more here.
Keywords: activity toxicity; antimicrobial activity; activity; molecular weight ... See more keywords
Sulfites in meat: Occurrence, activity, toxicity, regulation, and detection. A comprehensive review.
Sign Up to like & getrecommendations! Published in 2020 at "Comprehensive reviews in food science and food safety"
DOI: 10.1111/1541-4337.12607
Abstract: Sulfites are a class of chemical compounds, SO2 releasers, widely used as additives in food industry, due to their antimicrobial, color stabilizing, antibrowning, and antioxidant properties. As the results of these pleiotropic functions they can… read more here.
Keywords: sulfites meat; meat; occurrence activity; activity toxicity ... See more keywords
A feature transferring workflow between data-poor compounds in various tasks
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0266088
Abstract: Compound screening by in silico approaches has advantages in identifying high-activity leading compounds and can predict the safety of the drug. A key challenge is that the number of observations of drug activity and toxicity… read more here.
Keywords: activity toxicity; activity; drug activity; data poor ... See more keywords
Antifungal Activity, Toxicity, and Membranolytic Action of a Mastoparan Analog Peptide
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2019.00419
Abstract: Invasive fungal infections, such as cryptococcosis and paracoccidioidomycosis are associated with significant rates of morbidity and mortality. Cryptococcosis, caused by Cryptococcus neoformans, is distributed worldwide and has received much attention as a common complication in… read more here.
Keywords: toxicity; toxicity membranolytic; activity toxicity; antifungal activity ... See more keywords
Semisynthetic Amides of Amphotericin B and Nystatin A1: A Comparative Study of In Vitro Activity/Toxicity Ratio in Relation to Selectivity to Ergosterol Membranes
Sign Up to like & getrecommendations! Published in 2023 at "Antibiotics"
DOI: 10.3390/antibiotics12010151
Abstract: Polyene antifungal amphotericin B (AmB) has been used for over 60 years, and remains a valuable clinical treatment for systemic mycoses, due to its broad antifungal activity and low rate of emerging resistance. There is… read more here.
Keywords: ergosterol; comparative study; activity toxicity; toxicity ... See more keywords
Evaluation of New Antimicrobial Agents Based on tris(1H-Indol-3-yl)methylium Salts: Activity, Toxicity, Suppression of Experimental Sepsis in Mice
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceuticals"
DOI: 10.3390/ph15020118
Abstract: The antimicrobial activity and toxicity of three novel synthetic antibacterial agents containing tris(1H-indol-3-yl)methylium fragment were studied in vitro and in vivo. All compounds in vitro revealed high activity (minimal inhibitory concentration (MIC) 0.13–1.0 µg/mL) against… read more here.
Keywords: activity toxicity; indol methylium; toxicity; activity ... See more keywords