Human CYP2D6 Is Functional in Brain In Vivo: Evidence from Humanized CYP2D6 Transgenic Mice
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Neurobiology"
DOI: 10.1007/s12035-020-01896-4
Abstract: CYP2D metabolizes many drugs that act within the brain, and variable expression of CYP2D in the brain may alter local drug and metabolite levels sufficiently to affect behavioral responses. Transgenic mice that express human CYP2D6… read more here.
Keywords: human cyp2d6; activity vivo; brain; cyp2d activity ... See more keywords
Angiogenic activity in vivo of the particulate matter (PM10).
Sign Up to like & getrecommendations! Published in 2017 at "Ecotoxicology and environmental safety"
DOI: 10.1016/j.ecoenv.2017.02.036
Abstract: BACKGROUND Particulate matter (PM) is the most efficient vehicle for the inhalation and absorption of toxic substances into the body. METHOD The present study was aimed at testing the hypothesis that PM10 samples collected on… read more here.
Keywords: particulate matter; activity vivo; pm10; angiogenic activity ... See more keywords
Structure-guided design enables development of a hyperpolarized molecular probe for the detection of aminopeptidase N activity in vivo
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abj2667
Abstract: Dynamic nuclear polarization (DNP) is a cutting-edge technique that markedly enhances the detection sensitivity of molecules using nuclear magnetic resonance (NMR)/magnetic resonance imaging (MRI). This methodology enables real-time imaging of dynamic metabolic status in vivo… read more here.
Keywords: vivo; dnp; design; activity vivo ... See more keywords
Synthesis of Copper Oxide-Based Nanoformulations of Etoricoxib and Montelukast and Their Evaluation through Analgesic, Anti-Inflammatory, Anti-Pyretic, and Acute Toxicity Activities
Sign Up to like & getrecommendations! Published in 2022 at "Molecules"
DOI: 10.3390/molecules27041433
Abstract: Copper oxide nanoparticles (CuO NPs) were synthesized through the coprecipitation method and used as nanocarriers for etoricoxib (selective COX-2 inhibitor drug) and montelukast (leukotriene product inhibitor drug) in combination therapy. The CuO NPs, free drugs,… read more here.
Keywords: anti inflammatory; spectroscopy; activity vivo; copper oxide ... See more keywords