Cadherin-2 mediates spatiotemporal control of actomyosin contractility during zippering and neural tube closure in a simple chordate
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.254
Abstract: morphogenesis coupled to cell proliferation. Coordination of cell shape changes and cell divisions requires spatially-biased remodelling of actomyosin cytoskeleton in response to intrinsic or extrinsic inputs. In Caenorhabditis elegans zygotes, transient flows of cortical actomyosin… read more here.
Keywords: cell; actomyosin; cadherin mediates; actomyosin contractility ... See more keywords
Rebalancing of actomyosin contractility enables mammary tumor formation upon loss of E-cadherin
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-11716-6
Abstract: E-cadherin (CDH1) is a master regulator of epithelial cell adherence junctions and a well-established tumor suppressor in Invasive Lobular Carcinoma (ILC). Intriguingly, somatic inactivation of E-cadherin alone in mouse mammary epithelial cells (MMECs) is insufficient… read more here.
Keywords: tumor; cadherin; formation; actomyosin contractility ... See more keywords
Blockade of ROCK inhibits migration of human primary keratinocytes and malignant epithelial skin cells by regulating actomyosin contractility
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-56447-2
Abstract: Actomyosin contractility, crucial for several physiological processes including migration, is controlled by the phosphorylation of myosin light chain (MLC). Rho-associated protein kinase (ROCK) and Myosin light chain kinase (MLCK) are predominant kinases that phosphorylate MLC.… read more here.
Keywords: skin; migration; mlc; actomyosin contractility ... See more keywords
HAX1 impact on collective cell migration, cell adhesion, and cell shape is linked to the regulation of actomyosin contractility
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e19-05-0304
Abstract: HAX1 protein is involved in the regulation of apoptosis, cell motility and calcium homeostasis. Its overexpression was reported in several tumors, including breast cancer. This study demonstrates that HAX1 has an impact on collective, but… read more here.
Keywords: cell migration; regulation; impact collective; cell ... See more keywords
The Ajuba family protein Wtip regulates actomyosin contractility during vertebrate neural tube closure
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cell Science"
DOI: 10.1242/jcs.213884
Abstract: ABSTRACT Ajuba family proteins are implicated in the assembly of cell junctions and have been reported to antagonize Hippo signaling in response to cytoskeletal tension. To assess the role of these proteins in actomyosin contractility,… read more here.
Keywords: wtip; apical constriction; neural tube; ajuba family ... See more keywords