RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition
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DOI: 10.1126/sciadv.abn1382
Abstract: High-risk neuroblastoma, a pediatric tumor originating from the sympathetic nervous system, has a low mutation load but highly recurrent somatic DNA copy number variants. Previously, segmental gains and/or amplifications allowed identification of drivers for neuroblastoma… read more here.
Keywords: inhibition; chk1 inhibition; rrm2; formation ... See more keywords