Basiliximab for steroid‐refractory acute graft‐versus‐host disease: A real‐world analysis
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26475
Abstract: Steroid‐refractory (SR) acute graft‐versus‐host disease (aGVHD) is one of the leading causes of early mortality after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). We investigated the efficacy, safety, prognostic factors, and optimal therapeutic protocol for SR‐aGVHD… read more here.
Keywords: basiliximab; steroid refractory; refractory acute; acute graft ... See more keywords
OSI‐027 modulates acute graft‐versus‐host disease after liver transplantation in a rat model
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DOI: 10.1002/lt.24797
Abstract: Despite its rarity (1%‐2%), acute graft‐versus‐host disease after liver transplantation (LT‐aGVHD) has a high mortality rate (85%). A gradual decrease in regulatory T cells (Tregs) correlates with disease progression in a rat LT‐GVHD model, and… read more here.
Keywords: osi 027; model; liver transplantation; acute graft ... See more keywords
Biomarkers of Acute Graft-Versus-Host Disease: Surface Antigens and Micro Rnas in Extracellular Vesicles
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DOI: 10.1016/j.bbmt.2018.12.223
Abstract: Introduction Biomarkers could be crucial to identify patients at high-risk of acute Graft-vs.-Host Disease (aGVHD). Given their involvement in inflammation, Extracellular Vesicles (EVs) may become attractive biomarkers. Moreover, EVs are non-invasively extracted from body fluids.… read more here.
Keywords: cell adhesion; host disease; surface antigens; adhesion molecule ... See more keywords
Gut Dysbiosis Increases Gut Barrier Damage during Anti-Leukemia Chemotherapy: Implications for Acute Graft-Versus-Host Disease
Sign Up to like & getrecommendations! Published in 2019 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2018.12.433
Abstract: We recently reported an association between low pre-conditioning serum citrulline, reflecting unresolved gut barrier injury from prior chemotherapy, and higher incidence of grade II-IV acute graft-versus-host disease (aGVHD). Citrulline is an amino acid exclusively synthesized… read more here.
Keywords: chemotherapy; citrulline; acute graft; barrier damage ... See more keywords
Recipient‐derived IL‐22 alleviates murine acute graft‐versus‐host disease in association with reduced activation of antigen presenting cells
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DOI: 10.1016/j.cyto.2018.08.010
Abstract: HighlightsKnock out of IL‐22 in recipients aggravates hepatic and intestinal aGVHD.IL‐22 mediates activation of dendritic cells.Recipient‐derived IL‐22 regulates polarization of Th1 cells and Tregs in aGVHD. Abstract Acute graft‐versus‐host disease (aGVHD) remains a major challenging… read more here.
Keywords: agvhd; recipient derived; versus host; recipient ... See more keywords
Chitinase 3‐like‐1 deficient donor splenocytes accentuated the pathogenesis of acute graft‐versus‐host diseases through regulating T cell expansion and type I inflammation
Sign Up to like & getrecommendations! Published in 2017 at "International Immunopharmacology"
DOI: 10.1016/j.intimp.2017.03.010
Abstract: Abstract Acute graft‐versus‐host disease (aGVHD) is a major complication following transplantation, limiting the success of this therapy. Chitinase 3‐like‐1 (CHI3L1), a member of the glycosyl hydrolase 18 family, plays a critical role in bacterial infections,… read more here.
Keywords: expansion; chi3l1; pathogenesis; donor ... See more keywords
Prevention of acute graft-versus-host-disease by Withaferin a via suppression of AKT/mTOR pathway.
Sign Up to like & getrecommendations! Published in 2020 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2020.106575
Abstract: Acute Graft versus Host Disease (aGVHD) is a frequent and serious complication in patients receiving allogeneic bone marrow transplantation (allo-BMT) and often requires rigorous prophylaxis. The current treatment regimens for aGVHD are associated with several… read more here.
Keywords: graft; versus host; host disease; acute graft ... See more keywords
Intravenous mesenchymal stromal cell therapy for inflammatory bowel disease: Lessons from the acute graft versus host disease experience.
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DOI: 10.1016/j.jcyt.2017.03.006
Abstract: Bone marrow-derived mesenchymal stromal cells (BMSCs) are primitive, supportive cells of the bone marrow with tri-lineage potential to differentiate into bone, cartilage, fat and muscle. These cells possess both in vitro and in vivo immunomodulatory… read more here.
Keywords: mesenchymal stromal; versus host; disease; host disease ... See more keywords
Adequate CD4+ T-cell reconstitution enhances survival probability after acute graft-versus-host-disease
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DOI: 10.1016/j.jcyt.2019.03.421
Abstract: Background & Aim Background Acute Graft-versus-Host-Disease (aGvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic (stem) cell transplantation (HCT). Studies evaluating the relation between immune reconstitution (IR) and aGvHD are largely lacking.… read more here.
Keywords: acute graft; cd4; agvhd; adequate cd4 ... See more keywords
Extracorporeal photopheresis as first-line strategy in the treatment of acute graft-versus-host disease after hematopoietic stem cell transplantation: a single-center experience.
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DOI: 10.1016/j.jcyt.2020.03.003
Abstract: BACKGROUND AIMS Corticosteroids are the standard first-line treatment for acute graft-versus-host disease (aGVHD), but they are associated with many complications, and less than half of patients have a sustained response. METHODS To improve outcomes, we… read more here.
Keywords: line; first line; treatment; treatment acute ... See more keywords
CXCR3 blockade combined with cyclosporine A alleviates acute graft‐versus‐host disease by inhibiting alloreactive donor T cell responses in a murine model
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DOI: 10.1016/j.molimm.2017.12.010
Abstract: HIGHLIGHTSCXCR3 antagonist together with CsA had a synergy effect to mitigate aGvHD in a murine aGvHD model.The mechanism relied on inhibiting of donor‐derived T cell responses.AMG487 combined with CsA decreased the oncentrations of pro‐inflammatory cytokines… read more here.
Keywords: cell responses; versus host; donor; model ... See more keywords