Long-term follow-up of a single institution pilot study of sirolimus, tacrolimus, and short course methotrexate for graft versus host disease prophylaxis in mismatched unrelated donor allogeneic stem cell transplantation
Sign Up to like & getrecommendations! Published in 2018 at "Annals of Hematology"
DOI: 10.1007/s00277-018-3427-1
Abstract: Dear Editor, Allogeneic stem cell transplantation (allo-SCT) is a potentially curative treatment for patients with hematologic malignancies [1]. However, overall survival (OS) is often compromised by treatment-related complications such as graftversus-host disease (GVHD). Recipients of… read more here.
Keywords: sirolimus tacrolimus; acute gvhd; methotrexate; study ... See more keywords
Pediatric Acute Gvhd: Transcriptome Analysis of Gastrointestinal Biopsies Reveal a Unique Signature in Pediatric Acute GI Gvhd with Involvement of the ERK Pathway and Similarities with Pediatric Inflammatory Bowel Disease
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.138
Abstract: Introduction Studies of target organs at the time of acute graft versus host disease (GVHD) are needed to identify novel inflammatory and regulatory pathways. Methods We performed a prospective transcriptome analysis of gastrointestinal (GI) biopsies… read more here.
Keywords: acute gvhd; analysis; disease; gvhd ... See more keywords
IL12 and IFNγ secretion by donor mononuclear cells in response to host antigens may predict acute GVHD after HSCT.
Sign Up to like & getrecommendations! Published in 2019 at "Immunobiology"
DOI: 10.1016/j.imbio.2019.07.001
Abstract: One persistent problem of allogeneic hematopoietic stem cell transplantation (HSCT) is acute graft versus host disease (GVHD). The role of cytokines in the pathogenesis of GVHD has been acknowledged. We aimed, in the current study,… read more here.
Keywords: may predict; gvhd; acute gvhd; il12 ifn ... See more keywords
Association between single nucleotide polymorphisms of tumor necrosis factor gene and grade II–IV acute GvHD: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2017 at "Bone Marrow Transplantation"
DOI: 10.1038/bmt.2017.144
Abstract: Acute GvHD (aGvHD) complicates up to 50% of allogeneic hematopoietic cell transplants and pre-transplant estimation of its risk can guide prophylaxis, monitoring and early intervention strategies. Inspired by the role of tumor necrosis factor alpha… read more here.
Keywords: acute gvhd; association; tumor necrosis; gvhd ... See more keywords
Extracellular vesicles as potential biomarkers of acute graft-vs-host disease
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DOI: 10.1038/leu.2017.277
Abstract: Acute graft-vs-host disease (GVHD) is a serious complication after allografting. We carried out an exploratory study to investigate a potential correlation of surface antigens on extracellular vesicles (EVs) and acute GVHD. EVs were extracted from… read more here.
Keywords: extracellular vesicles; acute gvhd; graft host; host disease ... See more keywords
Individual HLAs influence immunological events in allogeneic stem cell transplantation from HLA-identical sibling donors
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DOI: 10.1038/s41409-020-01070-3
Abstract: In allogeneic hematopoietic stem cell transplantation (allo-HSCT), the effects of patient and donor human leukocyte antigen (HLA) matching status on graft-versus-host disease (GVHD) have been extensively elucidated, but the effects of specific HLAs on acute… read more here.
Keywords: acute gvhd; identical sibling; cell transplantation; stem cell ... See more keywords
Grade 2 acute GVHD is a factor of good prognosis in patients receiving peripheral blood stem cells haplo-transplant with post-transplant cyclophosphamide
Sign Up to like & getrecommendations! Published in 2020 at "Acta Oncologica"
DOI: 10.1080/0284186x.2020.1837947
Abstract: Abstract Background The impact of acute graft versus host disease (GVHD) on survivals for patients receiving a haploidentical allogeneic stem-cell transplant (Allo-SCT) with peripheral blood stem-cells (PBSC) complemented by post-transplant cyclophosphamide (PTCY) is ill-known. Material… read more here.
Keywords: transplant; gvhd; acute gvhd; gvhd factor ... See more keywords
In Vivo Analysis of Human Immune Responses in Immunodeficient Rats
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DOI: 10.1097/tp.0000000000003047
Abstract: Supplemental Digital Content is available in the text. Background. Humanized immune system immunodeficient mice have been extremely useful for the in vivo analyses of immune responses in a variety of models, including organ transplantation and… read more here.
Keywords: gvhd; immunodeficient rats; acute gvhd; rrgs animals ... See more keywords
Similar incidence of severe acute GVHD and less severe chronic GVHD in PBSCT from unmanipulated, haploidentical donors compared with that from matched sibling donors for patients with haematological malignancies
Sign Up to like & getrecommendations! Published in 2017 at "British Journal of Haematology"
DOI: 10.1111/bjh.14331
Abstract: The features of graft‐versus‐host disease (GVHD) were compared between patients who underwent myeloablative conditioning and received a peripheral blood stem cell transplant (PBSCT) from either a haploidentical donor (HID) or a matched sibling donor (MSD)… read more here.
Keywords: acute gvhd; group; gvhd; pbsct ... See more keywords
Time-to-event analysis when the event is defined on a finite time interval
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DOI: 10.1177/0962280219869364
Abstract: Acute graft-versus-host disease (GVHD) is a frequent complication following hematopoietic cell transplantation (HCT). Research on risk factors for acute GVHD has tended to ignore two important clinical issues. First, post-transplant mortality is high. In our… read more here.
Keywords: finite time; acute gvhd; time; time event ... See more keywords
Tissue tolerance: a distinct concept to control acute GVHD severity.
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DOI: 10.1182/blood-2016-09-740431
Abstract: Target tissue damage occurs as a consequence of pathological immune responses following allogeneic stem cell transplantation resulting in acute graft-versus-host disease (GVHD). Among those who study infections in plants, it is well recognized that tissues… read more here.
Keywords: acute gvhd; tolerance; tissue; gvhd ... See more keywords