Prediction of acute inhalation toxicity using cytotoxicity data from human lung epithelial cell lines
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4090
Abstract: Recent research on in vitro systems has focused on mimicking the in vivo situation of cells within the respiratory system. However, few studies have predicted inhalation toxicity using conventional and simple submerged two‐dimensional (2D) cell… read more here.
Keywords: toxicity using; inhalation toxicity; acute inhalation; inhalation ... See more keywords
Elevated Neuroglobin Lessens Neuroinflammation and Alleviates Neurobehavioral Deficits Induced by Acute Inhalation of Combustion Smoke in the Mouse
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DOI: 10.1007/s11064-019-02856-8
Abstract: Acute inhalation of combustion smoke produces long-term neurologic deficits in survivors. To study the mechanisms that contribute to the development of neurologic deficits and identify targets for prevention, we developed a mouse model of acute… read more here.
Keywords: combustion smoke; smoke; acute inhalation; inhalation ... See more keywords
In vitro model for predicting acute inhalation toxicity by using a Calu-3 epithelium cytotoxicity assay.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of pharmacological and toxicological methods"
DOI: 10.1016/j.vascn.2019.04.002
Abstract: INTRODUCTION As the current methods to predict the inhalation toxicity of chemicals using animal models are limited, alternative methods are required. We present a new in vitro prediction method for acute inhalation toxicity using the… read more here.
Keywords: cytotoxicity assay; epithelium; inhalation toxicity; acute inhalation ... See more keywords
In vitro Alternatives to Acute Inhalation Toxicity Studies in Animal Models—A Perspective
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DOI: 10.3389/fbioe.2020.00549
Abstract: When assessing the risk and hazard of a non-pharmaceutical compound, the first step is determining acute toxicity, including toxicity following inhalation. Inhalation is a major exposure route for humans, and the respiratory epithelium is the… read more here.
Keywords: inhalation toxicity; toxicity; vitro alternatives; acute inhalation ... See more keywords
Assessment of acute inhalation toxicity of citric acid and sodium hypochlorite in rats
Sign Up to like & getrecommendations! Published in 2023 at "Journal of Veterinary Science"
DOI: 10.4142/jvs.22253
Abstract: Background Citric acid (CA) and sodium hypochlorite (NaOCl) have been used to disinfect animals to protect them against avian influenza and foot-and-mouth disease. Objectives We performed a good laboratory practice (GLP)-compliant animal toxicity study to… read more here.
Keywords: citric acid; inhalation toxicity; acid sodium; toxicity ... See more keywords