Transcription control by the ENL YEATS domain in acute leukemia
Sign Up to like & getrecommendations! Published in 2017 at "Nature"
DOI: 10.1038/nature21688
Abstract: Recurrent chromosomal translocations producing a chimaeric MLL oncogene give rise to a highly aggressive acute leukaemia associated with poor clinical outcome. The preferential involvement of chromatin-associated factors as MLL fusion partners belies a dependency on… read more here.
Keywords: transcription control; enl; yeats domain; acute leukaemia ... See more keywords
SARS-CoV-2 antibody responses in patients with acute leukaemia
Sign Up to like & getrecommendations! Published in 2020 at "Leukemia"
DOI: 10.1038/s41375-020-01103-2
Abstract: We read with interest the letter by Roeker et al., on SARSCoV-2 antibody responses in twenty-one patients with chronic lymphocytic leukemia (CLL), reporting that 67% generated antibodies to the SARS-CoV-2 Nucleoprotein antigen [1]. Their report… read more here.
Keywords: acute leukaemia; patients acute; sars cov; leukemia ... See more keywords
Paediatric ambiguous lineage leukaemia with monocytic differentiation at diagnosis: case series and review of literature
Sign Up to like & getrecommendations! Published in 2021 at "British Journal of Haematology"
DOI: 10.1111/bjh.17852
Abstract: Ambiguous lineage leukaemia (ALAL) is a rare sub-type of paediatric acute leukaemia. There are four main subgroups according to the lineage of differentiation, namely: (i) mixed phenotype acute leukaemia (MPAL), (ii) bilineal acute leukaemia, (iii)… read more here.
Keywords: leukaemia; ambiguous lineage; diagnosis; lineage ... See more keywords
HLA peptide‐binding pocket diversity modulates immunological complications after cord blood transplant in acute leukaemia
Sign Up to like & getrecommendations! Published in 2024 at "British Journal of Haematology"
DOI: 10.1111/bjh.19339
Abstract: Pocket motifs and their amino acid positions of HLA molecules are known to govern antigen presentation to effector cells. Our objective was to analyse their influence on the risk of graft‐versus‐host disease (GVHD) and relapse… read more here.
Keywords: cord blood; hla; pocket; blood transplant ... See more keywords
Reproductive patterns and birth rates in acute leukaemia survivors: A Danish population‐based cohort study
Sign Up to like & getrecommendations! Published in 2025 at "British Journal of Haematology"
DOI: 10.1111/bjh.20238
Abstract: Treatment‐related infertility is of great concern to younger long‐term survivors of acute leukaemia (AL). This study aimed to assess birth rates and cumulative incidences of first live birth, use of assisted reproduction technology (ART) and… read more here.
Keywords: birth; reproductive patterns; population; acute leukaemia ... See more keywords
Role of CXCR4 in the progression and therapy of acute leukaemia
Sign Up to like & getrecommendations! Published in 2021 at "Cell Proliferation"
DOI: 10.1111/cpr.13076
Abstract: CXCR4 is expressed on leukaemia cells and haematopoietic stem cells (HSCs), and its ligand stromal‐derived factor 1 (SDF‐1) is produced abundantly by stromal cells in the bone marrow (BM). The SDF‐1/CXCR4 axis plays important roles… read more here.
Keywords: acute leukaemia; leukaemia cells; cxcr4 progression; leukaemia ... See more keywords
Longitudinal symptom burden in adult patients with acute leukaemia participating in the PACE-AL randomised controlled exercise trial-an explorative analysis.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of cancer care"
DOI: 10.1111/ecc.13462
Abstract: OBJECTIVE Patients with acute leukaemia undergoing chemotherapy experience multiple symptoms that interfere with activities of daily living. Exercise-based interventions have been used to remedy disease and treatment-related symptoms in patients with cancer. We explored the… read more here.
Keywords: patients acute; exercise; acute leukaemia; symptom burden ... See more keywords
Acute leukaemia with a pure erythroid phenotype: under‐recognized morphological and cytogenetic signatures associated universally with primary refractory disease and a dismal clinical outcome
Sign Up to like & getrecommendations! Published in 2017 at "Histopathology"
DOI: 10.1111/his.13207
Abstract: Pure erythroid leukaemia (PEL) is an extremely rare and aggressive subtype of acute myeloid leukaemia defined by the World Health Organization (WHO) as a neoplastic proliferation of immature cells committed exclusively to the erythroid lineage,… read more here.
Keywords: pure erythroid; acute leukaemia; pure; erythroid phenotype ... See more keywords
P378 Molecular diagnostic markers for childhood acute leukaemia – a single centre experience
Sign Up to like & getrecommendations! Published in 2017 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2017-313273.466
Abstract: Background Acute lymphoblastic leukaemia (ALL) is the most common malignancy during childhood and has a high cure rate. On the other hand, the prognosis of acute myeloid leukaemia (AML) remains poor despite progress achieved over… read more here.
Keywords: acute leukaemia; treatment; centre; p378 molecular ... See more keywords
G551(P) Complications of hyperleukocytosis in acute leukaemia: wcc risk threshold analysis
Sign Up to like & getrecommendations! Published in 2019 at "Archives of Disease in Childhood"
DOI: 10.1136/archdischild-2019-rcpch.534
Abstract: Aims Acute leukaemia presenting with hyperleukocytosis (white cell count (WCC) >50×109/L) is associated with organ dysfunction due to hyperviscosity. However, there is little evidence to guide which children are at highest risk and who might… read more here.
Keywords: risk; acute leukaemia; initial wcc; complications hyperleukocytosis ... See more keywords
Intracerebral haemorrhage as an initial manifestation of T-cell acute lymphoblastic leukaemia in a paediatric patient
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DOI: 10.1136/bcr-2022-252594
Abstract: © BMJ Publishing Group Limited 2022. No commercial reuse. See rights and permissions. Published by BMJ. DESCRIPTION A previously healthy teenage boy presented to an outside emergency department for oral bleeding and worsening headache. Examination… read more here.
Keywords: acute leukaemia; leukaemia; lymphoblastic leukaemia; intracerebral haemorrhage ... See more keywords