Discovery of PRMT3 Degrader for the Treatment of Acute Leukemia
Sign Up to like & getrecommendations! Published in 2024 at "Advanced Science"
DOI: 10.1002/advs.202405963
Abstract: Protein arginine methyltransferase 3 (PRMT3) plays an important role in gene regulation and a variety of cellular functions, thus, being a long sought‐after therapeutic target for human cancers. Although a few PRMT3 inhibitors are developed… read more here.
Keywords: discovery prmt3; prmt3; degrader treatment; prmt3 degrader ... See more keywords
Hereditary chronic neutrophilic leukemia in a four‐generation family without transformation to acute leukemia
Sign Up to like & getrecommendations! Published in 2024 at "American Journal of Hematology"
DOI: 10.1002/ajh.27420
Abstract: Chronic neutrophilic leukemia (CNL) is a rare myeloproliferative neoplasm (MPN) characterized by peripheral blood neutrophilia, marrow granulocyte hyperplasia, hepatosplenomegaly, and driver mutations in the colony‐stimulating factor 3 receptor (CSF3R). Designation of activating CSF3R mutations as… read more here.
Keywords: chronic neutrophilic; family; history; acute leukemia ... See more keywords
Childhood acute leukemia and type 1 diabetes in children: A nationwide case-control study.
Sign Up to like & getrecommendations! Published in 2025 at "International journal of cancer"
DOI: 10.1002/ijc.70122
Abstract: Etiology of childhood acute leukemia is largely unknown, though environmental factors and infection‐related immune responses may contribute. Type 1 diabetes mellitus (T1DM), an autoimmune disease also with onset primarily in childhood, shares risk factors with… read more here.
Keywords: childhood acute; type diabetes; leukemia; association ... See more keywords
Role of the perinatal experience on the risk of acute leukemia in childhood or adolescence: Systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2025 at "International journal of cancer"
DOI: 10.1002/ijc.70256
Abstract: Acute leukemia is the most common type of cancer in children; however, the etiology is poorly understood. The objective of this review was to summarize the current evidence of the role of perinatal factors in… read more here.
Keywords: review; risk; acute leukemia; leukemia ... See more keywords
E35 ablates acute leukemia stem and progenitor cells in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29457
Abstract: Leukemia stem cells (LSCs) have critical functions in acute leukemia (AL) pathogenesis, participating in its initiation and relapse. Thus, identifying new molecules to eradicate LSCs represents a high priority for AL management. This work identified… read more here.
Keywords: progenitor cells; acute leukemia; stem progenitor; stem ... See more keywords
The Emotion and Symptom‐Focused Engagement (EASE) Psychotherapeutic Intervention for Parents of Children With Acute Leukemia: A Feasibility Trial
Sign Up to like & getrecommendations! Published in 2025 at "Psycho-Oncology"
DOI: 10.1002/pon.70310
Abstract: Parents of children newly diagnosed with acute leukemia (AL) experience significant traumatic stress that adversely affects their well‐being, caregiving capacity, and family functioning. However, rigorous evidence of the feasibility and effectiveness of psychosocial interventions for… read more here.
Keywords: symptom focused; emotion symptom; parents children; feasibility ... See more keywords
Novel biallelic ATM mutations coexist with a mosaic form of triple X syndrome in an 11-year-old girl at remission after T cell acute leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Immunogenetics"
DOI: 10.1007/s00251-018-1056-4
Abstract: Ataxia-telangiectasia (AT) is a rare neurodegenerative disease characterized by an early onset ataxia, oculocutaneous telangiectasia, immunodeficiency, recurrent infections, radio-sensitivity, and a predisposition to malignancy. We present the case of a child with coexistent AT and… read more here.
Keywords: old girl; remission cell; acute leukemia; girl remission ... See more keywords
The clinical efficacy of a daratumumab-based regimen in relapsed/refractory acute leukemia: a single-center experience
Sign Up to like & getrecommendations! Published in 2024 at "Annals of Hematology"
DOI: 10.1007/s00277-024-05892-9
Abstract: Relapsed/refractory acute leukemia (R/R-AL) is associated with a low remission rate, short survival rate, and poor prognosis. Treating R/R-AL remains challenging as there is no standardized effective regimen; hence, there is a need for efficient… read more here.
Keywords: daratumumab based; leukemia; refractory acute; relapsed refractory ... See more keywords
Damage control surgery in intracerebral hemorrhage in acute leukemia: a review of two cases
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DOI: 10.1007/s00381-017-3401-6
Abstract: IntroductionIntracerebral hemorrhage is the second most common cause of mortality (after infections) in acute leukemia and is responsible for approximately 20% of deaths due to acute leukemia. Management of intracerebral hemorrhage (ICH) is mostly conservative… read more here.
Keywords: surgery; damage control; intracerebral hemorrhage; hemorrhage ... See more keywords
Comparative study of liposomal amphotericin B, posaconazole, and micafungin for primary antifungal prophylaxis in pediatric patients with acute leukemia
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Cancer Research and Clinical Oncology"
DOI: 10.1007/s00432-025-06289-5
Abstract: Invasive fungal diseases (IFDs) are a significant cause of morbidity and mortality in pediatric patients with hematologic malignancies including acute leukemia. Our study aimed to compare the efficacy of liposomal amphotericin B (L-AMB), posaconazole or… read more here.
Keywords: micafungin; posaconazole micafungin; patients acute; pediatric patients ... See more keywords
TSC gene expression in the newly diagnosed Egyptian acute leukemia patients
Sign Up to like & getrecommendations! Published in 2018 at "Comparative Clinical Pathology"
DOI: 10.1007/s00580-018-2722-5
Abstract: TSC (tuberous sclerosis) complex is the major negative regulator of mTOR which activates cell cycle progression leading to uncontrolled growth. Acute leukemias are very heterogeneous as a group of hematological malignancies; they arise as a… read more here.
Keywords: tsc gene; gene expression; acute leukemia; leukemia patients ... See more keywords