E35 ablates acute leukemia stem and progenitor cells in vitro and in vivo
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29457
Abstract: Leukemia stem cells (LSCs) have critical functions in acute leukemia (AL) pathogenesis, participating in its initiation and relapse. Thus, identifying new molecules to eradicate LSCs represents a high priority for AL management. This work identified… read more here.
Keywords: progenitor cells; acute leukemia; stem progenitor; stem ... See more keywords
Novel biallelic ATM mutations coexist with a mosaic form of triple X syndrome in an 11-year-old girl at remission after T cell acute leukemia
Sign Up to like & getrecommendations! Published in 2018 at "Immunogenetics"
DOI: 10.1007/s00251-018-1056-4
Abstract: Ataxia-telangiectasia (AT) is a rare neurodegenerative disease characterized by an early onset ataxia, oculocutaneous telangiectasia, immunodeficiency, recurrent infections, radio-sensitivity, and a predisposition to malignancy. We present the case of a child with coexistent AT and… read more here.
Keywords: old girl; remission cell; acute leukemia; girl remission ... See more keywords
Damage control surgery in intracerebral hemorrhage in acute leukemia: a review of two cases
Sign Up to like & getrecommendations! Published in 2017 at "Child's Nervous System"
DOI: 10.1007/s00381-017-3401-6
Abstract: IntroductionIntracerebral hemorrhage is the second most common cause of mortality (after infections) in acute leukemia and is responsible for approximately 20% of deaths due to acute leukemia. Management of intracerebral hemorrhage (ICH) is mostly conservative… read more here.
Keywords: surgery; damage control; intracerebral hemorrhage; hemorrhage ... See more keywords
TSC gene expression in the newly diagnosed Egyptian acute leukemia patients
Sign Up to like & getrecommendations! Published in 2018 at "Comparative Clinical Pathology"
DOI: 10.1007/s00580-018-2722-5
Abstract: TSC (tuberous sclerosis) complex is the major negative regulator of mTOR which activates cell cycle progression leading to uncontrolled growth. Acute leukemias are very heterogeneous as a group of hematological malignancies; they arise as a… read more here.
Keywords: tsc gene; gene expression; acute leukemia; leukemia patients ... See more keywords
Genistein-induced Anticancer Effects on Acute Leukemia Cells Involve the Regulation of Wnt Signaling Pathway Through H4K20me1 Rather Than DNA Demethylation
Sign Up to like & getrecommendations! Published in 2021 at "Current Medical Science"
DOI: 10.1007/s11596-021-2445-8
Abstract: To investigate the effects and mechanisms of genistein on the gene expression in the Wnt pathway in acute leukemia (AL) cells. The expression of Wnt pathway genes and cell cycle-related genes were analyzed in two… read more here.
Keywords: genistein; leukemia cells; cell cycle; acute leukemia ... See more keywords
Correlation of Calcium and Magnesium Levels in the Biological Samples of Different Types of Acute Leukemia Children
Sign Up to like & getrecommendations! Published in 2018 at "Biological Trace Element Research"
DOI: 10.1007/s12011-018-1340-z
Abstract: Acute leukemia (AL) is a common childhood malignancy. It is clinically and morphologically heterogeneous. The present work was intended to estimate the concentration of calcium (Ca) and magnesium (Mg) in serum and whole blood samples… read more here.
Keywords: biological samples; acute leukemia; calcium magnesium;
HLA-haploidentical peripheral blood stem cell transplantation following reduced-intensity conditioning with very low-dose antithymocyte globulin for relapsed/refractory acute leukemia in pediatric patients: a single-institution retrospective analysis
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Hematology"
DOI: 10.1007/s12185-021-03270-z
Abstract: The prognosis of relapsed/refractory (R/R) pediatric acute leukemia is extremely poor. We retrospectively reviewed 20 consecutive pediatric patients with R/R acute leukemia who underwent a first HLA-haploidentical peripheral blood stem cell transplantation following reduced-intensity conditioning… read more here.
Keywords: relapsed refractory; leukemia; hla haploidentical; pediatric patients ... See more keywords
Thiotepa Based Conditioning for Haploidentical Stem Cell Transplantation with Post Transplant Cyclophosphamide for Pediatric Acute Leukemia Is Highly Effective
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2019.12.719
Abstract: Introduction Haploidentical family donor is universally available and is increasing being used as an alternative donor choice for treating adults with leukaemia needing hematopoietic stem cell transplant (HSCT). Thiotepa is an alkylating agent which has… read more here.
Keywords: cell; thiotepa based; acute leukemia; day ... See more keywords
Timing of Post-Transplantation Cyclophosphamide Administration in Haploidentical Transplantation: A Comparative Study on Behalf of the Acute Leukemia Working Party of the European Society for Blood and Marrow Transplantation
Sign Up to like & getrecommendations! Published in 2020 at "Biology of Blood and Marrow Transplantation"
DOI: 10.1016/j.bbmt.2020.06.026
Abstract: ABSTRACT The timing of immunosuppressive therapy used in combination with post-transplantation cyclophosphamide (PTCY) in haploidentical hematopoietic stem cell transplant (haplo-HSCT) is not standardized. We evaluated the schedules of immunosuppression therapy after haplo-HSCT in 509 patients… read more here.
Keywords: post transplantation; transplantation cyclophosphamide; acute leukemia; transplantation ... See more keywords
Monitoring minimal residual disease in acute leukemia: Technical challenges and interpretive complexities.
Sign Up to like & getrecommendations! Published in 2017 at "Blood reviews"
DOI: 10.1016/j.blre.2016.09.006
Abstract: Minimal residual disease (MRD) after therapy has unequivocal prognostic value in acute leukemia. Over the past 20years, a number of techniques have evolved into routine laboratory tools to detect MRD, most notably, multiparametric flow cytometry… read more here.
Keywords: residual disease; acute leukemia; minimal residual; mrd ... See more keywords
Unrelated donor umbilical cord blood transplant versus unrelated hematopoietic stem cell transplant in patients with acute leukemia: A meta-analysis and systematic review.
Sign Up to like & getrecommendations! Published in 2018 at "Blood reviews"
DOI: 10.1016/j.blre.2017.11.003
Abstract: Acute leukemia is a global disease with a poor prognosis for many patients. While an increasing number of patients with acute leukemia are being treated with unrelated hematopoietic stem cell transplants (HSCT) or umbilical cord… read more here.
Keywords: cord blood; patients acute; transplant; acute leukemia ... See more keywords