The international consensus classification of myeloid neoplasms and acute Leukemias: myeloproliferative neoplasms
Sign Up to like & getrecommendations! Published in 2022 at "American Journal of Hematology"
DOI: 10.1002/ajh.26751
Abstract: A group of international experts, including hematopathologists, oncologists, and geneticists were recently summoned (September 2021, Chicago, IL, USA) to update the 2016/17 World Health Organization classification system for hematopoietic tumors. After careful deliberation, the group… read more here.
Keywords: neoplasms acute; classification; acute leukemias; myeloid neoplasms ... See more keywords
Patient‐reported outcome assessment in acute leukemias: Moving beyond the barriers
Sign Up to like & getrecommendations! Published in 2018 at "Cancer"
DOI: 10.1002/cncr.31521
Abstract: We have read with interest the article by Kantarjian et al in which they report unique evidence-based data on the impact of inotuzumab ozogamicin on the quality of life of patients with relapsed/refractory acute lymphoblastic… read more here.
Keywords: quality; acute leukemias; assessment; quality life ... See more keywords
Acute Leukemias of Ambiguous Lineage: Clarification on Lineage Specificity.
Sign Up to like & getrecommendations! Published in 2019 at "Surgical pathology clinics"
DOI: 10.1016/j.path.2019.03.008
Abstract: Acute leukemias of ambiguous lineage (ALAL) include acute undifferentiated leukemia and mixed-phenotype acute leukemia (MPAL). This article provides an overview of the diagnosis of ALAL and focuses on the data accounting for the current lineage-assignment… read more here.
Keywords: acute; lineage; leukemias ambiguous; ambiguous lineage ... See more keywords
Therapeutic implications of menin inhibition in acute leukemias
Sign Up to like & getrecommendations! Published in 2021 at "Leukemia"
DOI: 10.1038/s41375-021-01309-y
Abstract: Menin inhibitors are novel targeted agents currently in clinical development for the treatment of genetically defined subsets of acute leukemia. Menin has a tumor suppressor function in endocrine glands. Germline mutations in the gene encoding… read more here.
Keywords: acute leukemia; menin; menin inhibition; acute leukemias ... See more keywords
A Machine Learning Approach to the Classification of Acute Leukemias and Distinction From Nonneoplastic Cytopenias Using Flow Cytometry Data.
Sign Up to like & getrecommendations! Published in 2021 at "American journal of clinical pathology"
DOI: 10.1093/ajcp/aqab148
Abstract: OBJECTIVES Flow cytometry (FC) is critical for the diagnosis and monitoring of hematologic malignancies. Machine learning (ML) methods rapidly classify multidimensional data and should dramatically improve the efficiency of FC data analysis. We aimed to… read more here.
Keywords: flow cytometry; nonneoplastic cytopenias; machine; acute leukemias ... See more keywords
Abstract 6163: Fusion landscape in acute leukemias: A submerged world of not routinely characterized transcripts
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DOI: 10.1158/1538-7445.am2023-6163
Abstract: Background: Fusions (Fs) are major molecular biological abnormalities in acute leukemias (ALs), and all well-known Fs in leukemias are founder variations are routinely used as molecular markers for the diagnosis, classification, risk stratification, and targeted… read more here.
Keywords: submerged world; landscape acute; fusion; leukemias submerged ... See more keywords
The Role of Inhibition of Apoptosis in Acute Leukemias and Myelodysplastic Syndrome
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2019.00192
Abstract: Avoidance of apoptosis is a key mechanism that malignancies, including acute leukemias and MDS, utilize in order to proliferate and resist chemotherapy. Recently, venetoclax, an inhibitor of the anti-apoptotic protein BCL-2, has been approved for… read more here.
Keywords: apoptosis acute; acute leukemias; role inhibition; myelodysplastic syndrome ... See more keywords
Editorial: Acute leukemias: molecular characterization, leukemia-initiating cells, and influence of the microenvironment
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2023.1199354
Abstract: COPYRIGHT © 2023 Dancik, Varisli, Voutsas and Vlahopoulos. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted,… read more here.
Keywords: leukemia initiating; acute leukemias; characterization leukemia; editorial acute ... See more keywords
Novel Diagnostic and Therapeutic Options for KMT2A-Rearranged Acute Leukemias
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.749472
Abstract: The KMT2A (MLL) gene rearrangements (KMT2A-r) are associated with a diverse spectrum of acute leukemias. Although most KMT2A-r are restricted to nine partner genes, we have recently revealed that KMT2A-USP2 fusions are often missed during… read more here.
Keywords: novel diagnostic; acute leukemias; inhibitor; acute leukemia ... See more keywords
Cranial MRI in Childhood Acute Leukemia during Treatment and Follow-Up Including the Impact of Intrathecal MTX—A Single-Center Study and Review of the Literature
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DOI: 10.3390/cancers14194688
Abstract: Simple Summary Acute leukemias in children have an excellent outcome. Therefore, reasons for long-term sequelae need to be discovered to avoid them. Our retrospective analysis in addition to a literature review focuses on neurotoxicity by… read more here.
Keywords: childhood acute; intrathecal mtx; impact intrathecal; mtx ... See more keywords
AgNOR patterns and configurations in adult acute leukemia patients
Sign Up to like & getrecommendations! Published in 2023 at "Central-European Journal of Immunology"
DOI: 10.5114/ceji.2022.124252
Abstract: The number of argyrophilic nucleolus organizer regions (AgNOR) is related to the proliferative activity of cells and the degree of neoplastic transformation. The surface area of AgNOR depending on nuclear structure may be a predictor… read more here.
Keywords: agnor structures; agnor patterns; acute leukemias; leukemia ... See more keywords