Bioinspired Artificial Liver System with hiPSC-derived Hepatocytes for Acute Liver Failure Treatment.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202101580
Abstract: Bioartificial liver (BAL) system has become a promising alternative to traditional liver transplantation in rescuing acute liver failure (ALF) patients. Herein, inspired by natural microstructure of hepatic lobules, we developed a novel biomimetic bioartificial liver… read more here.
Keywords: derived hepatocytes; liver failure; system; acute liver ... See more keywords
A Biomimetic Nanoparticle Exerting Protection Against Acute Liver Failure by Suppressing CYP2E1 Activity and Scavenging Excessive ROS.
Sign Up to like & getrecommendations! Published in 2023 at "Advanced healthcare materials"
DOI: 10.1002/adhm.202300571
Abstract: Acute liver failure (ALF) is a severe liver disease caused by many reasons. One of them is the overdosed acetaminophen (APAP), which is metabolized into N-acetyl-p-benzoquinone imine (NAPQI), an excessive toxic metabolite, by CYP2E1, resulting… read more here.
Keywords: cyp2e1; liver; liver failure; acute liver ... See more keywords
Oridonin ameliorates acetaminophen‐induced acute liver injury through ATF4/PGC‐1α pathway
Sign Up to like & getrecommendations! Published in 2022 at "Drug Development Research"
DOI: 10.1002/ddr.22024
Abstract: Acetaminophen (APAP) overdose‐induced acute liver injury (ALI) causes hepatocyte cell death, oxidative stress, and inflammation. Oridonin (Ori), a covalent NLRP3‐inflammasome inhibitor, ameliorates APAP‐induced ALI through an unclear molecular mechanism. This study found that Ori decreased… read more here.
Keywords: apap; atf4 pgc; liver injury; acute liver ... See more keywords
Elevated FABP1 serum levels are associated with poorer survival in acetaminophen‐induced acute liver failure
Sign Up to like & getrecommendations! Published in 2017 at "Hepatology"
DOI: 10.1002/hep.28945
Abstract: Acetaminophen (APAP)‐induced acute liver failure (ALF) is associated with significant mortality. Traditional prognostic scores lack sensitivity. Serum liver‐type fatty acid binding protein (FABP1) early (day 1) or late (day 3‐5) levels are associated with 21‐day… read more here.
Keywords: liver failure; acute liver; serum; liver ... See more keywords
Indeterminate pediatric acute liver failure is uniquely characterized by a CD103+CD8+ T‐cell infiltrate
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.29901
Abstract: The cause of pediatric acute liver failure (PALF) is unknown in up to 40% of cases. Evidence suggests that aberrant immune system activation may play a role. We hypothesized that indeterminate PALF cases would exhibit… read more here.
Keywords: cd8; acute liver; dpalf; pediatric acute ... See more keywords
Liver Transplant Listing in Pediatric Acute Liver Failure: Practices and Participant Characteristics
Sign Up to like & getrecommendations! Published in 2018 at "Hepatology"
DOI: 10.1002/hep.30116
Abstract: Liver transplant (LT) decisions in pediatric acute liver failure (PALF) are complex. Three phases of the PALF registry, containing data on 1,144 participants over 15 years, were interrogated to characterize clinical features associated with listing… read more here.
Keywords: liver failure; acute liver; liver; liver transplant ... See more keywords
A Spotlight on the Drivers of Inflammation in Acute Liver Failure
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DOI: 10.1002/hep.31815
Abstract: Acute liver failure (ALF) is an important cause of mortality in the western world, accounting for 1600 deaths per year in the United States1 . However, surprisingly little is known about the cellular underpinnings of… read more here.
Keywords: spotlight drivers; drivers inflammation; liver failure; acute liver ... See more keywords
Generation of neutrophil extracellular traps in patients with acute liver failure is associated with poor outcome.
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.32174
Abstract: BACKGROUND AND AIMS Acute liver failure (ALF) is characterized by significant changes in the hemostatic system and by systemic inflammation. The formation of neutrophil extracellular traps (NETs), in which an activated neutrophil expels its DNA,… read more here.
Keywords: neutrophil extracellular; liver failure; dna; acute liver ... See more keywords
Irbesartan mitigates acute liver injury, oxidative stress, and apoptosis induced by acetaminophen in mice
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22447
Abstract: Hepatotoxicity induced by acetaminophen (APAP)‐overdose is a major concern in clinical practice. In the present work, the detoxifying effect of irbesartan (Irb) on the APAP‐induced acute liver injury was evaluated in mice. Induction of acute… read more here.
Keywords: liver injury; stress; acute liver; apap induced ... See more keywords
Therapeutic plasma exchange in acute liver failure
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DOI: 10.1002/jca.21737
Abstract: Multi‐organ dysfunction in acute liver failure (ALF) has been attributed to a systemic inflammatory response directly triggered by the injured liver. High‐volume therapeutic plasma exchange (HV‐TPE) has been demonstrated in a large randomized controlled trial… read more here.
Keywords: therapeutic plasma; liver failure; plasma exchange; acute liver ... See more keywords
Downregulation of microRNA‐214 improves therapeutic potential of allogeneic bone marrow–derived mesenchymal stem cell by targeting PIM‐1 in rats with acute liver failure
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.28560
Abstract: Acute liver failure (ALF) is a disease resulted from diverse etiology, which generally leads to a rapid degenerated hepatic function. However, transplantation bone marrow–derived mesenchymal stem cells (BMSCs) transplantation has been suggested to relieve ALF.… read more here.
Keywords: liver failure; acute liver; transplantation; expression ... See more keywords