Polymyxin B-Polysaccharide Polyion Nanocomplex with Improved Biocompatibility and Unaffected Antibacterial Activity for Acute Lung Infection Management.
Sign Up to like & getrecommendations! Published in 2020 at "Advanced healthcare materials"
DOI: 10.1002/adhm.201901542
Abstract: The decade-old antibiotic, polymyxin B (PMB), is regarded as the last line defense against gram-negative "superbug." However, the serious nephrotoxicity and neurotoxicity strongly obstruct further application of this highly effective antibiotic. Herein, a charge switchable… read more here.
Keywords: antibacterial activity; pmb; polyion nanocomplex; acute lung ... See more keywords
An mTOR siRNA‐Loaded Spermidine/DNA Tetrahedron Nanoplatform with a Synergistic Anti‐Inflammatory Effect on Acute Lung Injury (Adv. Healthcare Mater. 11/2022)
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Healthcare Materials"
DOI: 10.1002/adhm.202200008
Abstract: Acute lung injury (ALI) is characterized by severe inflammation and damage to the lung air-blood barrier, resulting in respiratory function damage and life-threatening outcomes. Macrophage polarization plays an essential role in the occurrence, development, and… read more here.
Keywords: acute lung; dna; lung injury; anti inflammatory ... See more keywords
Nano-Enabled Reposition of Proton Pump Inhibitors for TLR Inhibition: Toward A New Targeted Nanotherapy for Acute Lung Injury.
Sign Up to like & getrecommendations! Published in 2021 at "Advanced science"
DOI: 10.1002/advs.202104051
Abstract: Toll-like receptor (TLR) activation in macrophages plays a critical role in the pathogenesis of acute lung injury (ALI). While TLR inhibition is a promising strategy to control the overwhelming inflammation in ALI, there still lacks… read more here.
Keywords: proton pump; nano enabled; tlr; lung injury ... See more keywords
Discovery of new cinnamic derivatives as anti‐inflammatory agents for treating acute lung injury in mice
Sign Up to like & getrecommendations! Published in 2022 at "Archiv der Pharmazie"
DOI: 10.1002/ardp.202200191
Abstract: The blockade of the overexpression of pro‐inflammatory cytokines by anti‐inflammatory natural products has been proven therapeutically beneficial in the treatment of acute lung injury (ALI). Given the fact that cinnamic acid has been proven to… read more here.
Keywords: cinnamic derivatives; anti inflammatory; acute lung; lung injury ... See more keywords
USP9X promotes lipopolysaccharide‐stimulated acute lung injury by deubiquitination of NLRP3
Sign Up to like & getrecommendations! Published in 2022 at "Cell Biology International"
DOI: 10.1002/cbin.11932
Abstract: Alveolar epithelial cells (AECs) function as a vital defense barrier avoiding the invasion of exogenous agents and preserving the functional and structural integrity of lung tissues, while damage/breakdown of this airway epithelial barrier is frequently… read more here.
Keywords: acute lung; lung injury; pyroptosis; lung ... See more keywords
L6H9 attenuates LPS‐induced acute lung injury in rats through targeting MD2
Sign Up to like & getrecommendations! Published in 2019 at "Drug Development Research"
DOI: 10.1002/ddr.21607
Abstract: Acute lung injury (ALI) is a clinical syndrome characterized by respiratory failure and acute inflammatory response. Myeloid differentiation protein 2 (MD2) has been reported to play a pivotal role in the recognition of LPS and… read more here.
Keywords: md2; lps induced; acute lung; attenuates lps ... See more keywords
Dachengqi decoction alleviates acute lung injury and inhibits inflammatory cytokines production through TLR4/NF‐κB signaling pathway in vivo and in vitro
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.27615
Abstract: Sepsis that arises from uncontrolled pulmonary inflammation could induce acute lung injury (ALI), leading to the high death rate. Dachengqi decoction (DCQD) is a common traditional Chinese herbal medicine with strong anti‐inflammatory effects. The current… read more here.
Keywords: dachengqi decoction; cytokines production; acute lung; inflammatory cytokines ... See more keywords
Prognostic value of pulmonary ultrasound score combined with plasma miR‐21‐3p expression in patients with acute lung injury
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Clinical Laboratory Analysis"
DOI: 10.1002/jcla.24275
Abstract: The aim of this study was to explore the value of the combination between lung ultrasound score (LUS) and the expression of plasma miR‐21‐3p in predicting the prognosis of patients with acute lung injury (ALI). read more here.
Keywords: acute lung; lung injury; plasma mir; ultrasound score ... See more keywords
Anti‐inflammatory effect of octyl gallate in alveolar macrophages cells and mice with acute lung injury
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Cellular Physiology"
DOI: 10.1002/jcp.29536
Abstract: Acute lung injury (ALI) is an inflammatory process, and has high incidence and mortality. ALI and the acute respiratory distress syndrome are two common complications worldwide that result in acute lung failure, sepsis, and death.… read more here.
Keywords: anti inflammatory; alveolar macrophages; acute lung; lung injury ... See more keywords
Sophoridine inhibits endotoxin‐induced acute lung injury by enhancing autophagy of macrophage and reducing inflammation
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Leukocyte Biology"
DOI: 10.1002/jlb.3ma0322-428r
Abstract: Acute lung injury (ALI) is characterized by uncontrolled inflammation, which can lead to respiratory distress syndrome and cause patient death. In this study, we sought to determine the role of sophoridine, a compound purified from… read more here.
Keywords: acute lung; inflammation; lung injury; sophoridine ... See more keywords
Topotecan reduces sepsis‐induced acute lung injury and decreases the inflammatory response via the inhibition of the NF‐κB signaling pathway
Sign Up to like & getrecommendations! Published in 2022 at "Pulmonary Circulation"
DOI: 10.1002/pul2.12070
Abstract: Abstract This study aims to determine the function of topotecan (TPT) in acute lung injury (ALI) induced by sepsis. The mouse sepsis model was constructed through cecal ligation and puncture (CLP). The ALI score and… read more here.
Keywords: sepsis; acute lung; lung injury; lung ... See more keywords