Effect of a Daily Text Messaging and Directly Supervised Therapy Intervention on Oral Mercaptopurine Adherence in Children With Acute Lymphoblastic Leukemia
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DOI: 10.1001/jamanetworkopen.2020.14205
Abstract: Key Points Question In children with acute lymphoblastic leukemia receiving oral mercaptopurine, can an intervention consisting of education and daily text message reminders to prompt directly supervised therapy result in a higher proportion of patients… read more here.
Keywords: intervention; lymphoblastic leukemia; acute lymphoblastic; children acute ... See more keywords
Mortality Among Pediatric Patients With Acute Lymphoblastic Leukemia in Sweden From 1988 to 2017
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DOI: 10.1001/jamanetworkopen.2022.43857
Abstract: This cohort study compares mortality among Swedish pediatric patients diagnosed with acute lymphoblastic leukemia with that in the general population of Sweden from 1988 to 2017. read more here.
Keywords: mortality among; lymphoblastic leukemia; acute lymphoblastic; 1988 2017 ... See more keywords
Salvage Chemoimmunotherapy With Inotuzumab Ozogamicin Combined With Mini–Hyper-CVD for Patients With Relapsed or Refractory Philadelphia Chromosome–Negative Acute Lymphoblastic Leukemia: A Phase 2 Clinical Trial
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DOI: 10.1001/jamaoncol.2017.2380
Abstract: Importance The outcome of patients with relapsed or refractory (R/R) acute lymphoblastic leukemia (ALL) is poor. Inotuzumab ozogamicin, a CD22 monoclonal antibody bound to calicheamicin, has single-agent activity in R/R ALL. Objective To evaluate the… read more here.
Keywords: relapsed refractory; inotuzumab; salvage; acute lymphoblastic ... See more keywords
Association Between Anesthesia Exposure and Neurocognitive and Neuroimaging Outcomes in Long-term Survivors of Childhood Acute Lymphoblastic Leukemia.
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DOI: 10.1001/jamaoncol.2019.1094
Abstract: Importance Limited studies have reported associations between anesthesia and neurocognitive and neuroimaging outcomes, particularly in pediatric patients who undergo multiple exposures to anesthesia as part of chronic disease management. Objective To investigate whether general anesthesia… read more here.
Keywords: childhood acute; long term; anesthesia; lymphoblastic leukemia ... See more keywords
Cost-effectiveness of Tisagenlecleucel vs Standard Care in High-risk Relapsed Pediatric Acute Lymphoblastic Leukemia in Canada.
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DOI: 10.1001/jamaoncol.2019.5909
Abstract: Importance Tisagenlecleucel, a chimeric antigen receptor T-cell therapy for relapsed or refractory pediatric acute lymphoblastic leukemia, has been approved for use in multiple jurisdictions. The public list price is US $475 000, or more than CaD… read more here.
Keywords: acute lymphoblastic; standard care; tisagenlecleucel; cost ... See more keywords
DEX-Induced SREBF1 Promotes BMSCs Differentiation into Adipocytes to Attract and Protect Residual T-Cell Acute Lymphoblastic Leukemia Cells After Chemotherapy.
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DOI: 10.1002/advs.202205854
Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignant blood disorder with a high rate of relapse. Patients relapse as a result of minimal residual disease (MRD), which originates from residual T-ALL cells in the… read more here.
Keywords: cell; leukemia; dex; acute lymphoblastic ... See more keywords
Acute myeloid leukemia with minimal differentiation (AML M0) mimicking acute lymphoblastic leukemia
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DOI: 10.1002/ajh.25354
Abstract: A 68-year-old man presented with a history of several months of weakness and weight loss, and was found to be pancytopenic (WBC = 2.02 K/μL, hemoglobin = 8.1 g/dL, hematocrit = 24.4%, platelet count =… read more here.
Keywords: leukemia minimal; myeloid leukemia; lymphoblastic leukemia; acute lymphoblastic ... See more keywords
Allogeneic hematopoietic stem cell transplantation from unrelated donors is associated with higher infection rates in children with acute lymphoblastic leukemia—A prospective international multicenter trial on behalf of the BFM‐SG and the EBMT‐PDWP
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DOI: 10.1002/ajh.25511
Abstract: Severe infections (SI) significantly impact on non‐relapse mortality after hematopoietic stem cell transplantation (HSCT). We assessed 432 children and adolescents with acute lymphoblastic leukemia (ALL) after total body irradiation based myeloablative HSCT within the multicenter… read more here.
Keywords: cell transplantation; lymphoblastic leukemia; stem cell; transplantation ... See more keywords
Philadelphia chromosome‐positive acute lymphoblastic leukemia at first relapse in the era of tyrosine kinase inhibitors
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DOI: 10.1002/ajh.25648
Abstract: Despite the advances in the management of Philadelphia chromosome‐positive (Ph+) acute lymphoblastic leukemia (ALL) with the introduction of tyrosine kinase inhibitors (TKIs), relapses remain challenging. We reviewed clinical data from adult patients with Ph + ALL who… read more here.
Keywords: first relapse; positive acute; lymphoblastic leukemia; acute lymphoblastic ... See more keywords
The early achievement of measurable residual disease negativity in the treatment of adults with Philadelphia‐negative B‐cell acute lymphoblastic leukemia is a strong predictor for survival
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DOI: 10.1002/ajh.25671
Abstract: The minimal or measurable residual disease (MRD) status following induction/consolidation chemotherapy is an important prognostic endpoint in adult patients with newly diagnosed acute lymphoblastic leukemia (ALL). However, the optimal time‐point (TP) of MRD assessment and… read more here.
Keywords: mrd; philadelphia negative; lymphoblastic leukemia; measurable residual ... See more keywords
Sickle cell disease in the Eastern Province of Saudi Arabia: Clinical and laboratory features
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DOI: 10.1002/ajh.26096
Abstract: proteasome inhibitor bortezomib by the pediatric preclinical testing program. Pediatr Blood Cancer. 2008;50(1):37-45. 7. Romaguera JE, Fayad LE, McLaughlin P, et al. Phase I trial of bortezomib in combination with rituximab-HyperCVAD alternating with rituximab, methotrexate… read more here.
Keywords: cell; disease; lymphoblastic leukemia; bortezomib ... See more keywords