The changing scenario of non-Down syndrome acute megakaryoblastic leukemia in children.
Sign Up to like & getrecommendations! Published in 2019 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2019.04.011
Abstract: Pediatric non-Down-syndrome acute megakaryoblastic leukemia (non-DS-AMKL) is a heterogeneous subtype of leukemia that has historically been associated with poor prognosis. Until the advent of large-scale genomic sequencing, the management of patients with non-DS-AMKL was very… read more here.
Keywords: non amkl; leukemia; syndrome acute; pediatric non ... See more keywords
Acute Megakaryoblastic Leukemia With Diffuse Periosteal Reaction of Bilateral Lower Extremities
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Pediatric Hematology/Oncology"
DOI: 10.1097/mph.0000000000001299
Abstract: We report the case of a 3-year-old girl diagnosed with acute megakaryoblastic leukemia, who presented after >1 year of bilateral leg pain. At times the pain was severe enough to prevent ambulation, prompting visits to… read more here.
Keywords: leukemia; periosteal reaction; megakaryoblastic leukemia; lower extremities ... See more keywords
Clinical impact of genomic characterization of 15 patients with acute megakaryoblastic leukemia–related malignancies
Sign Up to like & getrecommendations! Published in 2021 at "Cold Spring Harbor Molecular Case Studies"
DOI: 10.1101/mcs.a005975
Abstract: Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia but is approximately 500 times more likely to develop in children with Down syndrome (DS) through transformation of transient abnormal myelopoiesis (TAM). This… read more here.
Keywords: acute megakaryoblastic; megakaryoblastic leukemia; genomic characterization; clinical impact ... See more keywords
Addressing the conundrum of male predominance in mantle cell lymphoma using androgen receptor blockade
Sign Up to like & getrecommendations! Published in 2020 at "British Journal of Haematology"
DOI: 10.1111/bjh.16902
Abstract: Proc Natl Acad Sci USA. 2001;98:5776–9. 4. Torres L, Lisboa S, Vieira J, Cerveira N, Santos J, Pinheiro M, et al. Acute megakaryoblastic leukemia with a four-way variant translocation originating the RBM15-MKL1 fusion gene. Pediatr… read more here.
Keywords: acute megakaryoblastic; cell; megakaryoblastic leukemia; addressing conundrum ... See more keywords
A rare case of transformation from relapsed acute monocytic leukaemia with KMT2A::MLLT10 to acute megakaryoblastic leukaemia
Sign Up to like & getrecommendations! Published in 2022 at "British Journal of Haematology"
DOI: 10.1111/bjh.18414
Abstract: A 17yearold male patient had been diagnosed 10 months previously with acute monocytic leukaemia, corresponding to AMLM5 according to FrenchAmericanBritish (FAB) categorisation, with KMT2A::MLLT10. After induction and consolidation chemotherapy, he achieved a complete remission (CR).… read more here.
Keywords: leukaemia; monocytic leukaemia; kmt2a mllt10; acute megakaryoblastic ... See more keywords
Haematopoietic cell transplantation for children with acute megakaryoblastic leukaemia without Down syndrome
Sign Up to like & getrecommendations! Published in 2023 at "British Journal of Haematology"
DOI: 10.1111/bjh.18691
Abstract: Patients with acute megakaryoblastic leukaemia of Down syndrome (DS‐AMKL) have an excellent survival rate; however, patients with non‐DS‐AMKL experience poor outcomes. Therefore, this study retrospectively analysed 203 children with non‐DS‐AMKL who underwent their first haematopoietic… read more here.
Keywords: haematopoietic cell; non amkl; cell transplantation; acute megakaryoblastic ... See more keywords
Salvage Cord Blood Transplantation for Sustained Remission of Acute Megakaryoblastic Leukemia That Relapsed Early after Myeloablative Transplantation
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DOI: 10.2169/internalmedicine.6796-20
Abstract: Acute megakaryoblastic leukemia (AMKL) is a rare subtype of acute myeloid leukemia accompanied by an aggressive clinical course and dismal prognosis. We herein report a case of AMKL preceded by mediastinal germ cell tumor that… read more here.
Keywords: acute megakaryoblastic; megakaryoblastic leukemia; salvage cord; transplantation ... See more keywords
Down syndrome-like acute megakaryoblastic leukemia in a patient with Cornelia de Lange syndrome
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DOI: 10.3324/haematol.2017.178590
Abstract: Cornelia de Lange Syndrome (CdLS) is a rare autosomal dominant developmental disorder characterized by a distinctive facial dysmorphism and variable developmental anomalies including prenatal and postnatal growth delay, microcephaly, intellectual disability, upper limb anomalies and… read more here.
Keywords: acute megakaryoblastic; lange syndrome; syndrome like; like acute ... See more keywords
Immunophenotypic Analysis of Acute Megakaryoblastic Leukemia: A EuroFlow Study
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DOI: 10.3390/cancers14061583
Abstract: Simple Summary Acute megakaryoblastic leukemia (AMKL) is a rare and heterogeneous subtype of acute myeloid leukemia (AML). We show that such patients can be identified by flowcytometric immunophenotyping using the standardized EuroFlow panel. AMKL patients… read more here.
Keywords: amkl patients; immunophenotypic; leukemia; amkl ... See more keywords