Generation of the Acute Phencyclidine Rat Model for Proteomic Studies of Schizophrenia.
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DOI: 10.1007/978-3-319-52479-5_23
Abstract: Administration of the non-competitive N-methyl-D-aspartate (NMDA) receptor antagonist phencyclidine (PCP) to rodents has been used as the gold standard preclinical model for schizophrenia. PCP treatment induces hyperlocomotion and stereotypic behaviour, which resemble the positive symptoms… read more here.
Keywords: model; acute phencyclidine; generation acute; proteomic studies ... See more keywords