Academic Community Partnership in Acute Promyelocytic Leukemia and Early Mortality
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DOI: 10.1001/jamaoncol.2024.7033
Abstract: Key Points Question Does the use of a standardized algorithm and expert support in the treatment of acute promyelocytic leukemia academic and community centers decrease induction mortality? Findings In this nonrandomized clinical trial including 201… read more here.
Keywords: acute promyelocytic; academic community; mortality; promyelocytic leukemia ... See more keywords
Complications and early mortality in patients with acute promyelocytic leukemia treated in California
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Hematology"
DOI: 10.1002/ajh.25252
Abstract: globulin light chain glycosylation: a potential path to earlier AL diagnosis for a subset of patients. Leukemia. 2018. https://doi.org/10.1038/ s41375-018-0194-x 3. Kohlhagen MC, Barnidge DR, Mills JR, et al. Screening method for M-proteins in serum… read more here.
Keywords: acute promyelocytic; early mortality; patients acute; promyelocytic leukemia ... See more keywords
Recapturing disease response: A phase 2 study of carfilzomib 56 mg/m2 in patients with relapsed or refractory multiple myeloma who have progressed on carfilzomib 27 mg/m2
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25695
Abstract: 1. Lo-Coco F, Avvisati G, Vignetti M, et al. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med. 2013;369: 111-121. 2. Nagendra S, Meyerson H, Skallerud G, et al. Leukemias resembling… read more here.
Keywords: acute promyelocytic; myeloid leukemia; promyelocytic leukemia; acute myeloid ... See more keywords
Impact of insurance status on the survival of younger patients diagnosed with acute promyelocytic leukemia in the United States
Sign Up to like & getrecommendations! Published in 2021 at "Cancer"
DOI: 10.1002/cncr.33593
Abstract: Survival among patients diagnosed with acute promyelocytic leukemia (APL) has significantly improved with the use of all‐trans retinoic acid and arsenic trioxide. However, the need for immediate diagnosis and access to specialized care and the… read more here.
Keywords: acute promyelocytic; promyelocytic leukemia; diagnosed acute; patients diagnosed ... See more keywords
Long‐term follow‐up of a phase 2 study of all‐trans retinoic acid, arsenic trioxide, and gemtuzumab ozogamicin in acute promyelocytic leukemia
Sign Up to like & getrecommendations! Published in 2024 at "Cancer"
DOI: 10.1002/cncr.35662
Abstract: All‐trans retinoic acid (ATRA) and arsenic trioxide (ATO) combinations have produced excellent outcomes in patients with standard‐risk acute promyelocytic leukemia (APL). Herein, the authors update their long‐term results with the regimen of ATO‐ATRA and gemtuzumab… read more here.
Keywords: trans retinoic; retinoic acid; acute promyelocytic; long term ... See more keywords
Clinical profile and treatment outcomes in paediatric and adult acute promyelocytic leukemia: experience from a tertiary care centre in Northern India
Sign Up to like & getrecommendations! Published in 2025 at "Annals of Hematology"
DOI: 10.1007/s00277-025-06646-x
Abstract: Acute promyelocytic leukemia (APL) is a distinct and highly curable subtype of acute myeloid leukemia. However, early mortality due to hemorrhage, differentiation syndrome (DS), and infections remains a significant challenge, particularly in resource-limited settings. There… read more here.
Keywords: acute promyelocytic; risk; promyelocytic leukemia; mortality ... See more keywords
Successful treatment of acute promyelocytic leukemia in pregnancy with single-agent all-trans retinoic acid
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DOI: 10.1007/s00404-017-4583-6
Abstract: PurposeThe diagnosis of acute promyelocytic leukemia (APL) in pregnancy is an uncommon, life-threatening emergency. Choice of treatment and management of complications are challenging.MethodsWe report the case of a patient with diagnosis of APL at gestational… read more here.
Keywords: agent; pregnancy; acute promyelocytic; apl pregnancy ... See more keywords
Cell dynamics during differentiation therapy with all-trans retinoic acid in acute promyelocytic leukemia
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Hematology"
DOI: 10.1007/s12185-018-2472-9
Abstract: The introduction of all-trans retinoic acid (ATRA) has made acute promyelocytic leukemia (APL) a curable disease; however, early death prior to the completion of treatment remains a problem. In quantitative evaluation of response to ATRA… read more here.
Keywords: trans retinoic; acute promyelocytic; promyelocytic leukemia; differentiation ... See more keywords
A case of acute promyelocytic leukemia complicated by mitochondrial disease
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DOI: 10.1007/s12185-025-03992-4
Abstract: A 15-year-old boy with congenital mitochondrial disease was diagnosed with acute promyelocytic leukemia. He was treated with all-trans retinoic acid, and his anthracycline dose was reduced in response to his underlying condition. He successfully achieved… read more here.
Keywords: acute promyelocytic; case acute; promyelocytic leukemia; mitochondrial disease ... See more keywords
The global problem of early deaths in acute promyelocytic leukemia: A strategy to decrease induction mortality in the most curable leukemia.
Sign Up to like & getrecommendations! Published in 2018 at "Blood reviews"
DOI: 10.1016/j.blre.2017.09.001
Abstract: Acute promyelocytic leukemia (APL) is a hyper-acute illness and presents with profound cytopenias in most patients and disseminated intravascular coagulation (DIC). Excellent treatment options are now available with drugs such as all-trans retinoic acid (ATRA),… read more here.
Keywords: early deaths; acute promyelocytic; promyelocytic leukemia; global problem ... See more keywords
Characterization of a rarely reported STAT5B/RARA gene fusion in a young adult with newly diagnosed acute promyelocytic leukemia with resistance to ATRA therapy.
Sign Up to like & getrecommendations! Published in 2019 at "Cancer genetics"
DOI: 10.1016/j.cancergen.2019.06.007
Abstract: The detection of PML/RARA or variant RARA rearrangements is critical for the diagnosis and treatment of patients with newly diagnosed acute promyelocytic leukemia (APL). While most cases of APL harboring the PML/RARA fusion respond to… read more here.
Keywords: acute promyelocytic; fusion; diagnosed acute; rara ... See more keywords