Efficacy and mechanisms underlying the effects of allogeneic umbilical cord mesenchymal stem cell transplantation on acute radiation injury in tree shrews
Sign Up to like & getrecommendations! Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0239-z
Abstract: Umbilical cord mesenchymal stem cells (UC-MSCs) exert strong immunomodulatory effects and can repair organs. However, their roles in radiation injury remain unclear. We show that in tree shrews with acute radiation injury, injected UC-MSCs significantly… read more here.
Keywords: radiation injury; umbilical cord; acute radiation; injury ... See more keywords
Single nucleotide polymorphisms to predict acute radiation dermatitis in breast cancer patients: A systematic review and meta-analysis.
Sign Up to like & getrecommendations! Published in 2022 at "Critical reviews in oncology/hematology"
DOI: 10.1016/j.critrevonc.2022.103651
Abstract: PURPOSE To identify Single Nucleotide Polymorphisms (SNPs) that can predict acute radiation dermatitis (RD) in breast cancer patients (BC), and the association between SNPs and RD severity. METHODS We performed the search in seven databases… read more here.
Keywords: nucleotide polymorphisms; acute radiation; predict acute; dermatitis breast ... See more keywords
Protective effects of a cystine and theanine mixture against acute radiation injury in rats.
Sign Up to like & getrecommendations! Published in 2020 at "Environmental toxicology and pharmacology"
DOI: 10.1016/j.etap.2020.103395
Abstract: This study aims to examine the effects of cystine and theanine (CT), which increases glutathione biosynthesis, on the survival rate and acute radiation injury of the small intestine and bone marrow using a rat model.… read more here.
Keywords: effects cystine; radiation injury; acute radiation; cystine theanine ... See more keywords
Acute radiation risk assessment and mitigation strategies in near future exploration spaceflights.
Sign Up to like & getrecommendations! Published in 2020 at "Life sciences in space research"
DOI: 10.1016/j.lssr.2019.10.006
Abstract: As more exploration spaceflights are planned to travel beyond the protective Earth magnetosphere to deep space destinations, acute health risks due to possible high radiation doses during severe Solar Particle Events (SPEs) are of greater… read more here.
Keywords: assessment mitigation; acute radiation; exploration; risk assessment ... See more keywords
Integrative network analyses of transcriptomics data reveal potential drug targets for acute radiation syndrome
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-85044-5
Abstract: Recent political unrest has highlighted the importance of understanding the short- and long-term effects of gamma-radiation exposure on human health and survivability. In this regard, effective treatment for acute radiation syndrome (ARS) is a necessity… read more here.
Keywords: acute radiation; radiation syndrome; drug; potential drug ... See more keywords
Development of age-dependent dose modification factors for acute radiation lethality
Sign Up to like & getrecommendations! Published in 2018 at "International Journal of Radiation Biology"
DOI: 10.1080/09553002.2018.1547438
Abstract: Abstract Purpose: The aim of our work was to develop an approach to account for the impact of age at exposure on acute radiation lethality risk for the purpose of improving casualty estimation tools when… read more here.
Keywords: radiation lethality; age dependent; acute radiation; age ... See more keywords
A novel oral formulation of BIO 300 confers prophylactic radioprotection from acute radiation syndrome in mice.
Sign Up to like & getrecommendations! Published in 2021 at "International journal of radiation biology"
DOI: 10.1080/09553002.2021.1981556
Abstract: PURPOSE Exposure to high doses of ionizing radiation can result in hematopoietic acute radiation syndrome (H-ARS) and delayed effects of acute radiation exposure (DEARE). There is no radiation medical countermeasure approved by the U.S. Food… read more here.
Keywords: acute radiation; radiation exposure; mice; bio 300 ... See more keywords
Delayed Renal Injury in Survivors of Hematologic Acute Radiation Syndrome.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of radiation biology"
DOI: 10.1080/09553002.2023.2170491
Abstract: Purpose: A mass casualty disaster involving radiological or nuclear agents continues to be a public health concern which requires consideration of both acute and late tissue toxicities in exposed victims. With the advent of advanced… read more here.
Keywords: renal injury; acute radiation; radiation syndrome; delayed renal ... See more keywords
Where are the medical countermeasures against the ARS and DEARE? A Current Topic Relative to an Animal Model Research Platform, Radiation Exposure Context, the Acute and Delayed Effects of Acute Exposure, and the FDA Animal Rule.
Sign Up to like & getrecommendations! Published in 2023 at "International journal of radiation biology"
DOI: 10.1080/09553002.2023.2181999
Abstract: Purpose. A question echoed by the National Biodefense Science Board (NBSB) in 2010, remains a reasonable question in 2023; "Where are the Countermeasures?" (Sawyer, 2010). A critical path for development of medical countermeasures (MCM) against… read more here.
Keywords: acute radiation; development; model; radiation ... See more keywords
Sargramostim in acute radiation syndrome
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2022.2143261
Abstract: ABSTRACT Introduction Since 1944, nearly 400 radiologic accidents/incidents have exposed about 3,000 people to substantial doses of ionizing radiation, with more than 125 deaths. Known are the Chernobyl and Fukushima nuclear power facility accidents, but… read more here.
Keywords: ionizing radiation; acute radiation; radiation syndrome; sargramostim ... See more keywords
Recent advances in medical countermeasure development against acute radiation exposure based on the US FDA animal rule
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Radiological Protection"
DOI: 10.1088/1361-6498/ac20e0
Abstract: Recent advances in medical countermeasures (MCMs) has been dependent on the Food and Drug Administration (FDA) animal rule (AR) and the final guidance document provided for industry on product development. The criteria outlined therein establish… read more here.
Keywords: acute radiation; exposure; recent advances; development ... See more keywords