Highs and lows of cannabinoid-dopamine interactions: effects of genetic variability and pharmacological modulation of catechol-O-methyl transferase on the acute response to delta-9-tetrahydrocannabinol in humans
Sign Up to like & getrecommendations! Published in 2019 at "Psychopharmacology"
DOI: 10.1007/s00213-019-05273-5
Abstract: AbstractRationaleThe catechol-O-methyl transferase (COMT) enzyme has been implicated in determining dopaminergic tone and the effects of delta-9-tetrahydrocannabinol (THC) in the human brain.ObjectiveThis study was designed to evaluate the effect of (1) a functional polymorphism and… read more here.
Keywords: methyl transferase; delta tetrahydrocannabinol; study; acute response ... See more keywords
Ascorbic acid increases SVCT2 localization at the plasma membrane by accelerating its trafficking from early secretory compartments and through the endocytic‐recycling pathway
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DOI: 10.1016/j.freeradbiomed.2018.03.013
Abstract: ABSTRACT Ascorbic acid (Asc) is an antioxidant molecule essential for physiological functions. The concentration of extracellular Asc increases during synaptic transmission and renal reabsorption. These phenomena induce an increase of the Sodium‐dependent‐Vitamin‐C‐transporter 2 (SVCT2) at… read more here.
Keywords: response; ascorbic acid; acute response; early secretory ... See more keywords
Metabolic requirements of NK cells during the acute response against retroviral infection
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DOI: 10.1038/s41467-021-25715-z
Abstract: Natural killer (NK) cells are important early responders against viral infections. Changes in metabolism are crucial to fuel NK cell responses, and altered metabolism is linked to NK cell dysfunction in obesity and cancer. However,… read more here.
Keywords: retroviral infection; metabolic requirements; cells acute; requirements cells ... See more keywords
Variations in Biodistribution and Acute Response of Differently Shaped Titania Nanoparticles in Healthy Rodents
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DOI: 10.3390/nano13071174
Abstract: Titanium dioxide nanoparticles (TiO2 NPs) are one of the main sources of the nanoparticulate matter exposure to humans. Although several studies have demonstrated their potential toxic effects, the real nature of the correlation between NP… read more here.
Keywords: variations biodistribution; biodistribution acute; acute response; accumulation ... See more keywords